Publications 2000-2008  
 

184. Weiner, H.L., Guttman, C.R., Khoury, S.J., Orav, E.J., Hohol, M.J., Kikinis, R., and Jolesz, F.A..  Serial magnetic resonance imaging in multiple sclerosis:  correlation with attacks, disability, and disease stage.  J Neuroimmunol 104(2): 164-73, 2000.

185. Balashov KE, Comabella M, Ohashi T, Khoury SJ, Weiner HL. Defective regulation of IFNgamma and IL-12 by endogenous IL-10 in progressive MS. Neurology 55:192-8, 2000.

186. Rottman JB, Slavin AJ, Silva R, Weiner HL, Gerard CG, Hancock WW. Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. Eur J Immunol 30:2372-7, 2000.

187. Khoury SJ, Guttmann CR, Orav EJ, Kikinis R, Jolesz FA, Weiner HL. Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis. Arch Neurol  57:1183-9, 2000.

188. Weiner, H.L., Lemere, C.A., Maron, R., Spooner, E.T., Grenfell, T.J., Mori, C., Issazadeh, S., Hancock, W.W. and Selkoe, D.J.  Nasal Administration of amyloid-beta peptide decreases cerebral amyloid burden in mouse model of Alzheimer’s Disease. Ann Neurol. 48:567-579. 2000.

189. Izikson, L., Klein, R. S., Charo, I. F., Weiner, H. L. and Luster, A. D. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor CCR2. J. Exp. Med.;192:1075-1080. 2000.

190. Yoles, E., Hauben, E., Palgi, O., Agranov, E., Kuchroo, V., Cohen, I. R., Weiner, H. L. and Schwartz, M. . Protective autoimmunity is a physiological response to central nervous system trauma. Journal of Neuroscience 21(11): 3740-3748. 2001.

191. Sperling, R. A., Guttmann, C. R. G., Hohol, M. J., Warfield, S. K., Jakab, M., Parente, M., Diamond, E. L., Daffner, K. R., Olek, M. J., Orav, E. J., Kikinis, R., Jolesz, F. A. and Weiner, H. L. . Regional MRI lesion burden and cognitive function in MS: a longitudinal study. Arch.Neurol. 58 (1): 115-121. 2001.

192. Maron, R., Guerau-de-Arellano, M., Zhang, X. and Weiner, H. L. . Oral administration of insulin to neonates suppresses spontaneous and cyclophosphamide induced diabetes in the NOD mouse. J. Autoimmun  16:21-8.  2001.

193. Spahn, T.W., Fontana, A., Faria, A.M.C., Slavin, A.J., Hans-Pietro, E., Zhang, X., Pandelakis, A.K., Ruddle, N.H., Flavell, R.A., Rennert, P.D. and Weiner, H.L.  Induction of oral tolerance to cellular immune responses in the absence of Peyer’s patches. Eur J Immunol  31(4):1278-87.  2001.

194. Slavin, A.J., Maron, R., and Weiner, H.L.  Mucosal administration of IL-10 enhances oral tolerance. Intl Immun. 13(6):825-33. 2001.

195. Makhlouf K, Comabella M, Imitola J, Weiner HL, Khoury SJ. Oral salbutamol decreases    IL-12 in patients with secondary progressive multiple sclerosis.  J Neuroimmunol 2:117:156-165. 2001.

196. Gonnella, PA, Waldner, HP, and Weiner, HL. B Cell-Deficient Mice Have Alterations in the Cytokine Microenvironment of the Gut-Associated Lymphoid Tissue (GALT) and a Defect in the Low Dose Mechanism of Oral Tolerance. J Immunol 166: 4456-4464. 2001.

197. Encinas JA, Lees MB, Sobel RA, Symonowicz C, Weiner HL, Seidman CE, Seidman JG, and Kuchroo VK. Identifiaction of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis. Intl Immunol 13 (3): 257-264. 2001.

198. Slavin AJ, Soos JM, Stuve O, Patarroyo JC, Weiner HL, Fontana A, Bikoff EK, Zamvil SS. Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity. J of Clin Invest 108 (8) 1133-1139. 2001.

199. Weiner HL. The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells. Nat Immunol. 2001 Aug;2(8):671-2.

200. Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner, HL. Immune hyporesponsiveness to amyloid B-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer’s disease. Proc Natl Acad Sci 98 (18); 10273-10278. 2001.

201. Zhang X, Izikson L, Liu L, and Weiner HL. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol. 2001 Oct 15;167(8):4245-53.

202. Makhlouf K., Weiner, H.L., Khoury, S.J.,  Increased percentage of IL-12+ Monocytes in the Blood Correlates with the Presence of Active MRI Lesions in MS.   J Neurol.  119:145-149. 2001.

203. Maron R and Weiner HL. Oral Tolerance to Cop 1 in MBP TCR transgenic mice: Cross-reactivity with MBP-specific TCRs and differential induction of anti-inflammatory cytokines. Int’l Immun. 14(2):131-138. 2002.

204. Karni A, Koldzic DN, Padmanabhan B, Khoury SJ, and Weiner, HL.  IL-18 is Linked to raised IFN-y in multiple sclerosis and is induced by activated CD4+ Cells via CD40-CD4- Ligand Interactions.  J Neuroimmunol.  125L134-140. 2002.

205. Spahn T, Weiner HL, Rennert PD, Kraft M, Lügerin N, Fontana A, Domschke W, Kucharzik T.  Mesenteric Lymph Nodes Are Critical for the Induction of Oral Tolerance.  European J. Immunol.  32:1109-1113. 2002.

206. Comabella M, Imitola J, Weiner HL, Khoury S.  Interferon-b treatment alters peripheral
Blood monocytes chemokine production in MS patients.  Journal of Neuroimmunology. 126:205-212. 2002.

207. Weiner HL, Cohen JA.  Treatment of multiple sclerosis with cyclophosphamide:  critical review of clinical and immunologic effects.  Multiple Sclerosis. 8:142-154. 2002.

208. Hommes OR, Weiner HL.  Results of an international questionnaire on immunosuppressive treatment of multiple sclerosis.  Multiple Sclerosis.  8:139-141.  2002.

209. Maron R, Sukhova G, Faria AM, Hoffman E, Mach F, Libby P, Weiner HL.  Mucosal Administration of Heat Shock Protein-65 Decreases Athrosclerosis and Inflammation in Aortic Arch of Low-Density Lipoprotein Receptor-Deficient Mice.  Circulation.  106:1708-1715. 2002.

210. Spahn TW, Hermann H, Rennert PD, Lugering N, Maaser C, Kraft M, Fontana A, Weiner HL, Domschke W, Kucharzik T.  Animal Model:  Induction of Colitis in Mice Deficient of Peyer’s Patches and Mesenteric Lymph Nodes Is Associate4d with Increased Disease Severity and Formation of Colonic Lymphoid Patches.  Am J. Pathol.  161:6:2273-2282.  Dec 2002.

211. Cotton F, Weiner HL, Jolesz FA, Guttmann CR. MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals.Neurology. 2003 Feb 25;60(4):640-6.

213.     Gonnella PA, Kodali D, Weiner HL. Induction of low dose oral tolerance in monocyte chemoattractant protein-1- and CCR2-deficient mice J Immunol. Mar 1;170(5):2316-22 2003.

214.     Oida T, Zhang X, Goto M, Hachimura S, Totsuka M, Kaminogawa S, Weiner HL.  CD4+CD25-T Cells That Express Latency-Associated Peptide on the Surface Suppress CD4+CD45RBhigh-Induced Colititis by a TGF-beta-Dependent Mechanism. J Immunol. 170:2516-2522.  2003.

215.     Faria AM, Maron R, Ficker SM, Slavin AJ, Spahn T, Weiner HL. Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis. J Autoimmun. Mar;20(2):135-45 2003.

216.     Hopfer H, Maron R, Butzmann U, Helmchen U, Weiner HL, Kalluri R. The importance of cell-mediated immunity in the course and severity of autoimmune anti-glomerular basement membrane disease in mice. FASEB J. 2003 May;17(8):
860-8.

217.     Bettelli E, Pagany M, Weiner HL, Linington C, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med. 2003 May 5;197(9):1073-81.

218.     Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest. 2003 Aug;112(3):415-22.

219.     Monsonego A, Beserman ZP, Kipnis J, Yoles E, Weiner HL, Schwartz M. Beneficial effect of orally administered myelin basic protein inEAE-susceptible Lewis rats in a model of acute CNS degeneration. J Autoimmun. 2003 Sep;21(2):131-8.

220.     Monsonego A, Imitola J, Zota V, Oida T, Weiner HL. Microglia-mediated nitric oxide cytotoxicity of T cells following amyloid beta-peptide presentation to Th1 cells. J Immunol. 2003 Sep 1;171(5):2216-24.

221.     Frenkel D, Huang Z, Maron R, Koldzic DN, Hancock WW, Moskowitz MA, Weiner HL. Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells. J Immunol. 2003 Dec 15;171(12):6549-55.

222.     Klein RS, Izikson L, Means T, Gibson HD, Lin E, Sobel RA, Weiner HL, Luster AD. IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis. J Immunol. 2004 Jan 1;172(1):550-9.

223.     Karni A, Balashov K, Hancock WW, Bharanidharan P, Abraham M, Khoury SJ, Weiner HL. Cyclophosphamide modulates CD4+ T cells into a T helper type 2 phenotype and reverses increased IFN-gamma production of CD8+ T cells in secondary progressive multiple sclerosis.
J Neuroimmunol. 2004 Jan;146(1-2):189-98.

224.     Zhang X, Koldzic DN, Izikson L, Reddy J, Nazareno RF, Sakaguchi S, Kuchroo VK, Weiner HL. IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. Int Immunol. 2004 Feb;16(2):249-56.

225.     Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med. 2004 Apr 5;199(7):971-9.

226.     Meier DS, Weiner HL, Khoury SJ, Guttmann CR. Magnetic resonance imaging surrogates of multiple sclerosis pathology and their relationship to central nervous system atrophy. J Neuroimaging. 2004 Jul;14:46S-53S.

227.     Cai G, Karni A, Oliveira EM, Weiner HL, Hafler DA, Freeman GJ. PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells.
Cell Immunol. 2004 Aug;230(2):89-98.

228.     Hommes OR, Weiner HL. Clinical practice of immunosuppressive treatments in multiple sclerosis: results of a second international questionnaire. J Neurol Sci. 2004 Aug 15;223(1):65-7.

229.     Gonnella PA, Waldner HP, Kodali D, Weiner HL. Induction of low dose oral tolerance in IL-10 deficient mice with experimental autoimmune encephalomyelitis. J Autoimmun. 2004 Nov;23(3):193-200.

230.     Hara H, Monsonego A, Yuasa K, Adachi K, Xiao X, Takeda S, Takahashi K, Weiner HL, Tabira T. Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease. J Alzheimers Dis. 2004 Oct;6(5):483-8.

231.     Abraham M, Shapiro S, Karni A, Weiner HL, Miller A. Gelatinases (MMP-2 and MMP-9) are preferentially expressed by Th1 vs. Th2 cells. J Neuroimmunol. 2005 Jun;163(1-2):157-64. Epub 2005 Apr 2.

232.   Frenkel D, Huang Z, Maron R, Koldzic DN, Moskowitz MA, Weiner HL.             Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke. J Neurol Sci. 2005 Jun 15;233(1-2):125-32.

233.   Prat A, Biernacki K, Saroli T, Orav JE, Guttmann CR, Weiner HL, Khoury SJ, Antel JPKinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability. Arch Neurol. 2005 May;62(5):795-800.

234. Faria AM, Weiner HL. Oral tolerance. Immunol Rev. 2005 Aug;206(1):232-59.

235. Frenkel D, Maron R, Burt DS, Weiner HL.   Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease. J Clin Invest. 2005 Sep 1;115(9):2423-2433.

236.     Smith DR, Weinstock-Guttman B, Cohen JA, Wei X, Gutmann C, Bakshi R, Olek M, Stone L, Greenberg S, Stuart D, Orav J, Stuart W, Weiner H. A randomized blinded trial of combination therapy with cyclophosphamide in patients-with active multiple sclerosis on interferon beta. Mult Scler. 2005 Oct;11(5):573-82.

237. Frohman EM, Stuve O, Havrdova E, Corboy J, Achiron A, Zivadinov R, Sorensen PS, Phillips JT, Weinshenker B, Hawker K, Hartung HP, Steinman L, Zamvil S, Cree BA, Hauser S, Weiner H, Racke MK, Filippi M.        Therapeutic considerations for disease progression in multiple sclerosis: evidence, experience, and future expectations. Arch Neurol. 2005 Oct;62(10):1519-30.

238.     Gauthier SA, Weiner HL. Cyclophosphamide therapy for MS. Int MS J. 2005 Aug;12(2):52-8.

239.   Miyamoto K, Kingsley CI, Zhang X, Jabs C, Izikson L, Sobel RA, Weiner HL, Kuchroo VK, Sharpe AH. The ICOS molecule plays a crucial role in the development of mucosal tolerance. J Immunol. 2005 Dec 1;175(11):7341-7.

240.     Zhang X, Reddy J, Ochi H, Frenkel D, Kuchroo VK, Weiner HL Recovery from experimental allergic encephalomyelitis is TGF-{beta} dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells. Int Immunol. 2006 Apr;18(4):495-503. Epub 2006 Mar 15.

241. Gonnella PA, Chen YH, Waldner H, Weiner HL. Induction of oral tolerization in CD86 deficient mice: A role for CD86 and B cells in the up-regulation of TGF-beta. J Autoimmun. 2006 Mar;26(2):73-81.

242.     Wu HY, Monsonego A, Weiner HL. The mechanism of nasal tolerance in lupus prone mice is T-cell anergy induced by immature B cells that lack B7 expression. J Autoimmun. 2006 Mar;26(2):116-26. Epub 2006 Jan 19.

243.     Vaknin-Dembinsky A, Balashov K, Weiner HL. IL-23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL-23 by Antisense Oligos Increases Dendritic Cell IL-10 Production. J Immunol. 2006 Jun 15;176(12):7768-7774.

Monsonego A, Imitola J, Petrovic S, Zota V, Nemirovsky A, Baron R, Fisher Y, Owens T, Weiner HL. Ab induced meningoencephalitis is IFN-g dependent and is associated with T-cell dependent clearance of Ab in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5048-53.

245.     Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006 May 11;441(7090):235-8.

246.     Ochi H, Abraham M, Ishikawa H, Frenkel D, Yang K, Basso AS, Wu H, Chen ML, Gandhi R, Miller A, Maron R, Weiner HL. Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4(+)CD25(-)LAP(+) T cells. Nat Med. 2006 May 21.
 
247.     Oida T, Xu L, Weiner HL, Kitani A, Strober W. TGF-beta-Mediated Suppression by CD4+CD25+ T Cells Is Facilitated by CTLA-4 Signaling. J Immunol 2006 177: 2331-2339.

248.     Faria AM, Weiner HL.            Oral Tolerance and TGF-beta-Producing Cells. Inflamm Allergy Drug Targets. 2006 Aug;5(3):179-90.

249.   Karni A, Abraham M, Monsonego A, Cai G, Freeman GJ, Hafler D, Khoury SJ, Weiner HL. Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response. J Immunol. 2006 Sep 15;177(6):4196-202.

250.   Gauthier SA, Glanz BI, Mandel M, Weiner HL. A model for the comprehensive investigation of a chronic autoimmune disease: the multiple sclerosis CLIMB study. Autoimmun Rev. 2006 Oct;5(8):532-6.

251.     Faria AM, Weiner HL. Oral tolerance: therapeutic implications for autoimmune diseases. Clin & Dev Immunology 2006 Jun-Dec; 13 (2-4):143-57.

252.     Mandel M, Gauthier SA, Guttmann CRG, Weiner HL, Betensky RA. Estimating time to event from longitudinal categorical data: an analysis of multiple sclerosis progression. J Am Stat Assoc. 2006

253.     Carrier Y, Yuan J, Kuchroo VK, Weiner HL. Th3 Cells in Peripheral Tolerance. I. Induction of Foxp3-Positive Regulatory T Cells by Th3 Cells Derived from TGF-beta T Cell-Transgenic Mice. J Immunol. 2007 Jan 1;178(1):179-185.

254.     Carrier Y, Yuan J, Kuchroo VK, Weiner HL.            Th3 Cells in Peripheral Tolerance. II. TGF-beta-Transgenic Th3 Cells Rescue IL-2-Deficient Mice from Autoimmunity. J Immunol. 2007 Jan 1;178(1):172-178.

255.     Gandhi R, Anderson DE, Weiner HL. Cutting Edge: Immature Human Dendritic Cells Express Latency-Associated Peptide and Inhibit T Cell Activation in a TGF-beta-Dependent Manner. J Immunol. 2007 Apr 1;178(7):4017-4021.

256.     Glanz BI, Holland CM, Gauthier SA, Amunwa EL, Liptak Z, Houtchens MK, Sperling RA, Khoury SJ, Guttmann CRG, Weiner HL. Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis. Multiple Sclerosis. 2007: 13: 1-7.

257.     Gauthier SA, Mandel M, Guttmann CRG, Glanz BI, Khoury SJ, Betensky RA, Weiner HL. Predicting short-term disability in multiple sclerosis. Neurology. Jun 12;68(24):2059-65.

258.     Ishikawa H, Ochi H, Chen ML, Frenkel D, Maron R, Weiner HL. Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody. Diabetes. 2007 Aug;56(8):2103-9.

259.     Glanz B, Holland C, Gauthier S, Amunwa E, Liptak Z, Houtchens M, Sperling R, Khoury S, Guttmann C, Weiner H. Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis. Mult Scler. 2007 Sep;13(8):1004-10. Epub 2007 Jul 10.

260.     Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL.A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol. 2007 Nov 11; [Epub ahead of print]

261.     Meier DS, Weiner HL, Guttmann CR. MR Imaging Intensity Modeling of Damage and Repair In Multiple Sclerosis: Relationship of Short-Term Lesion Recovery to Progression and Disability. AJNR Am J Neuroradiol. 2007 Nov-Dec;28(10):1956-63.

262.     Abraham M, Karni A, Dembinsky A, Miller A, Gandhi R, Anderson D, Weiner HL. In vitro induction of regulatory T cells by anti-CD3 antibody in humans. J Autoimmun. 2008 Feb-Mar;30(1-2):21-8.

263.     Sayegh MH, Weiner HL. Regulating rejection with cell therapy. Nat Biotechnol. 2008 Feb;26(2):191-2.

264.     Basso AS, Frenkel D, Quintana FJ, Costa-Pinto FA, Petrovic-Stojkovic S, Puckett L, Monsonego A, Bar-Shir A, Engel Y, Gozin M, Weiner HL. Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis. J Clin Invest. 2008 Apr 1;118(4):1532-1543.

265.     Frenkel D, Puckett L, Petrovic S, Xia W, Chen G, Vega J, Dembinsky-Vaknin A, Shen J, Plante M, Burt DS, Weiner HL.A nasal proteosome adjuvant activates microglia and prevents amyloid deposition. Ann Neurol. 2008 Mar 21.

266.     Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor.
Nature. 2008 Mar 23.

267.     Vaknin-Dembinsky A, Brass S, Gandhi R, Weiner HL. Membrane bound IL-15 is increased on CD14 monocytes in early stages of MS. J Neuroimmunol. 2008 Mar 29.

268.     Vaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL, Weiner HL. Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. J Neuroimmunol. 2008 Apr 8.

269.     Quintana FJ, Farez MF, Weiner HL. Systems biology approaches for the study of multiple sclerosis. J Cell Mol Med. 2008 May 26.

270.     Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL. Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGF{beta}-Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis. J Immunol. 2008 Jun 1;180(11):7327-37.

271.     Liptak Z, Berger AM, Sampat MP, Charil A, Felsovalyi O, Healy BC, Hildenbrand P, Khoury SJ, Weiner HL, Bakshi R, Guttmann CR. Medulla Oblongata Volume: A Biomarker of Spinal Cord Damage and Disability in Multiple Sclerosis. AJNR Am J Neuroradiol. 2008 Jun 12.