Publications 1980-89  
 
24. Weiner, H.L., Powers, M.L. and Fields, B.N.: Absolute linkage of virulence and central nervous system cell tropism of reoviruses to viral hemagglutinin. J. Infect. Dis. 141: 609–616, 1980.

25. Weiner, H.L., Ault, K.A. and Fields, B.N.: Interaction of reovirus with cell surface receptors. I. Murine and human lymphocytes have a receptor for the hemagglutinin of reovirus type 3. J. Immunol. 124: 2143–2148, 1980.

26. Weiner, H.L., Greene, M.I. and Fields, B.N.: Delayed type hypersensitivity in mice infected with reovirus. I. Identification of host and viral gene products responsible for the immune response. J. Immunol. 125: 278–282, 1980.

27. Greene, M.I. and Weiner, H.L.: Delayed hypersensitivity in mice infected with reovirus. II. Induction of tolerance and suppressor T cells to viral specific gene products. J. Immunol. 125: 283–287, 1980.

28. Reinherz, E.L., Weiner, H.L., Hauser, S.L., Cohen, J.A., Distaso, J.A. and Schlossman, S.F.: Loss of suppressor T cells in active multiple sclerosis. N. Engl. J. Med. 303: 125–129, 1980.

29. Fontana, A. and Weiner, H.L.: Interaction of reovirus with cell surface receptors. II. Generation of suppressor T cells by the hemagglutinin of reovirus type 3. J. Immunol. 125: 2660–2664, 1980.

30. Weiner, H.L. and Dawson, D.M.: Plasmapheresis in multiple sclerosis: preliminary study. Neurology 30: 1029–1033, 1980.

31. Finberg, R., Weiner, H.L., Burakoff, S.J. and Fields, B.N.: Type specific reovirus antiserum blocks the cytotoxic T cell target cell interaction: Evidence for the association of the viral hemagglutinin of a nonenveloped virus with the cell surface. Infect. Immun. 31: 646–649, 1981.

32. Rubin, D., Weiner, H.L., Fields, B.N. and Greene, M.I.: Immunologic tolerance after oral administration of reovirus: Requirement for two viral gene products for tolerance induction. J. Immunol. 127: 1698–1701, 1981.

33. Hauser, S.L., Ault, K.A., Levin, M., Garavoy, M. and Weiner, H.L.: Natural killer cell activity in multiple sclerosis. J. Immunol. 127: 1114–1117, 1981.

34. Epstein, R., Powers, M.L. and Weiner, H.L.: Interaction of reovirus with cell surface receptors. III. Reovirus type 3 induces capping of viral receptors on murine lymphocytes. J. Immunol. 127: 1800–1803, 1981.

35. Tardieu, M. and Weiner, H.L.: Viral receptors on isolated murine and human ependymal cells. Science 215: 419–421, 1982.

36. Nepom, J.T., Weiner, H.L., Dichter, M.A., Tardieu, M., Spriggs, D.R., Gramm, C.F., Powers, M.L., Fields, B.N., and Greene, M.I.: Identification of a hemagglutinin specific idiotype associated with reovirus recognition shared by lymphoid and neural cells. J. Exp. Med. 155: 155–167, 1982.

37. Hauser, S.L., Weiner, H.L. and Ault, K.A.: Clonally restricted B cells in peripheral blood of multiple sclerosis patients: kappa/lambda staining patterns. Ann. Neurol. 11: 408–412, 1982.

38. Hauser, S.L., Bresnan, M.J., Reinherz, E.L. and Weiner, H.L.: Childhood multiple sclerosis: Clinical features and demonstration of changes in T cell subsets with disease activity. Ann. Neurol. 11: 463–468, 1982.

39. Nepom, J.T., Tardieu, M., Epstein, R.L., Noseworthy, J.H., Weiner, H.L., Gentsch, J., Fields, B.N., and Greene, M.I.: Virus binding receptors: similarities to immune receptors as determined by anti idiotypic antibodies. Surv. Immunol. Res. 1: 255–261, 1982.

40. Hauser, S.L., Dawson, D.M., Lehrich J.R., Beal M.F., Kevy S.V., Propper R.D., Mills J.A., and Weiner H.L.: Intensive immunosuppression in progressive multiple sclerosis: A randomized, three arm study of high dose intravenous cyclophosphamide, plasma exchange and ACTH. N. Engl. J. Med. 308: 173–180, 1983.

41. Weiner, H.L. and Ellison, G.: A working protocol to be used as a guideline for trials in multiple sclerosis. Arch. Neurol. 40(11): 704–710, 1983.

42. Weiner, H.L., Dau, P., Birnbaum, G., Feldstein, M., Khatri, B., Petajan, J., and McQuillen, M.P.: Plasma exchange in acute multiple sclerosis. Design of a cooperative study. Arch. Neurol. 40(11): 691– 692, 1983.

43. Hauser, S.L., Dawson, D.M., Lehrich, J.R., Beal, M.F., Kevy, S.V., and Weiner, H.L.: Immunosuppression and plasmapheresis in chronic progressive multiple sclerosis. Design of a clinical trial. Arch. Neurol. 40(11): 687–690, 1983.

44. Hauser, S.L., Reinherz, E.L., Hoban, C.J., Schlossman, S.F., and Weiner, H.L.: Immunoregulatory T cells and lymphocytotoxic antibodies in active multiple sclerosis: weekly analysis over a six month period. Ann. Neurol. 13: 418–425, 1983.

45. Hauser, S.L., Reinherz, E.L., Hoban, C.J., Schlossman, S.F., and Weiner, H.L.: CSF cells in multiple sclerosis: monoclonal antibody analysis and relationship to peripheral blood T cell subsets. Neurology 33: 575–579, 1983.

46. Hauser, S.L., Bhan, A.K., Gilles, F., Hoban, C.J., Reinherz, E.L., Schlossman, S.F., and Weiner, H.L.: Immunohistochemical staining of human brain with monoclonal antibodies that identify lymphocytes, monocytes, and the Ia antigen. J. Neuroimmunol. 5: 197–205, 1983.

47. Tardieu, M., Powers, M.L., and Weiner, H.L.: Age dependent susceptibility to reovirus type 3 encephalitis: role of viral and host factors. Ann. Neurol. 13: 602–607, 1983.

48. Tardieu, M., Noseworthy, J.H., Perry, L., Che, M., Greene, M.I., and Weiner, H.L.: Generation of a monoclonal antibody (Epen1) which binds selectively to murine ependymal cells. Brain Res. 277: 339–346, 1983.

49. Crary, B., Hauser, S.L., Borysenko, M., Kutz, I., Hoban, C.J., Ault, K.A., Weiner, H.L., and Benson, H.: Epinephrine induced changes in the distribution of lymphocyte subsets in peripheral blood of humans. J. Immunol. 131: 1178–1181, 1983.

50. Tardieu, M., Powers, M.L., Hafler, D.A., Hauser, S.L., and Weiner, H.L.: Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with reovirus and demonstration of shared antigenicity between virus and lymphocytes. Eur. J. Immunol. 14: 561–569, 1984.

51. Epstein, R.L., Powers, M.L., Rogart, R.B., and H.L. Weiner: Binding of 125I labeled reovirus to cell surface receptors. Virology 133: 46–55, 1984.

52. Hauser, S.L., Weiner, H.L., Che, M., Shapiro, M.E., Gilles, F., and N.L. Letvin: Prevention of experimental allergic encephalomyelitis (EAE) in the SJL/J mouse by whole body ultraviolet irradiation. J. Immunol. 132: 1276–1281, 1984.

53. Weiner, H.L., Hafler, D.A., Fallis, R.J., Johnson, D., Ault, K.A., and S.L. Hauser: Altered blood T cell subsets in patients with multiple sclerosis. J. Neuroimmunol. 6: 115–121, 1984.

54. Hauser, S.L., Fosburg, M., Kevy, S.V., and H.L. Weiner: Lymphocytapheresis in chronic progressive multiple sclerosis: immunologic and clinical effects. Neurology 34: 922–926, 1984.

55. Epstein, R.L., Finberg, R., Powers, M.L., and H.L. Weiner: Interaction of reovirus with cell surface receptors. IV. The reovirus type 3 receptor is expressed predominantly on murine Lyt 2,3+ and human T8 cells. J. Immunol. 133: 1614–1617, 1984.

56. Dichter, M.A. and H.L. Weiner: Infection of neuronal cell cultures with reovirus mimics in vitro patterns of neurotropism. Ann. Neurol. 16: 603–610, 1984.

57. Hauser, S.L., Weiner, H.L., Bhan, A.K., Shapiro, M.E., Che, M., Aldrich, W.R., and N.L. Letvin: Lyt 1 cells mediate acute murine experimental allergic encephalomyelitis. J. Immunol. 133: 2288–2290, 1984.

58. Hauser, S.L., Bhan, A.K., Che, M., Gilles, F., and H.L. Weiner: Redistribution of Lyt bearing T cells in acute murine experimental allergic encephalomyelitis: selective migration of Lyt 1 cells to the central nervous system is associated with a transient depletion of Lyt 1 cells in peripheral blood. J. Immunol. 133: 3037–3042, 1984.

59. Hafler, D.A., Fox, D., Manning, M.E., Schlossman, S.F., Reinherz, E.L., and H.L. Weiner: In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N. Engl. J. Med. 312: 1405–1411, 1985.

60. Hafler, D.A., Buchsbaum, M., and H.L. Weiner: Decreased autologous mixed lymphocyte reaction in multiple sclerosis. J. Neuroimmunol. 9: 339–347, 1985.

61. Hafler, D.A., Buchsbaum, M., Johnson, D., and H.L. Weiner: Phenotypic and functional analysis of T cells cloned directly from the blood and cerebrospinal fluid of patients with multiple sclerosis. Ann. Neurol. 18: 451–458, 1985.

62. Hauser, S.L., Ault, K.A., Johnson, D., Hoban, C.J., and H.L. Weiner: Increased IgG secretion by unstimulated mononuclear cells in active multiple sclerosis and functional assessment of the T8 subset. Clin. Immunol. Immunopathol. 37: 312–323, 1985.

63. Hafler, D.A., Hemler, M., Christenson, L., Williams, J., Shapiro, H., Strom, T., Strominger, J.L., and H.L. Weiner: Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clin. Immunol. Immunopathol. 37: 163–171, 1985.

64. Hafler, D.A., Johnson, D., Kelly, J.J., Panitch, H., Kyle, R.A., and H.L. Weiner: Monoclonal gammopathy and neuropathy: Myelin associated glycoprotein reactivity and clinical characteristics. Neurology 36: 75–78, 1986.

65. Brown, R.H., Jr., Hauser, S.L., Harrington, H., and H.L. Weiner: Failure of immunosuppression with a ten to 14 day course of high dose intravenous cyclophosphamide to alter the progression of amyotrophic lateral sclerosis. Arch. Neurol. 43: 383–384, 1986.

66. Hauser, S.L., Bhan, A.K., Gilles, F., Kemp, M., Claire, K., and H.L. Weiner: Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann. Neurol. 19: 578–587, 1986.

67. Dichter, M.A., Weiner, H.L., Fields, B.N., Mitchell, G., Noseworthy, J., Gaulton, G., and M. Greene: Antiidiotypic antibody to reovirus binds to neurons and protects from viral infection. Ann. Neurol. 19: 555–558, 1986.

68. Hafler, D.A., Fallis, R.J., Dawson, D.M., Schlossman, S.F., Reinherz, E.L., and H.L. Weiner: Immunologic responses of progressive multiple sclerosis patients treated with anti T cell monoclonal antibody. Neurology 36: 777–784, 1986.

69. Hafler, D.A., Fox, D.A., Benjamin, D., and H.L. Weiner: Antigen reactive memory T cells are defined by Ta1. J. Immunol. 137: 414–418, 1986.

70. Johnson, D., Hafler, D.A., Fallis, R.J., Brady, R.O., Quarles, R.H., and H.L. Weiner: Cell mediated immunity to myelin associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis. J. Neuroimmunol. 13: 99–108, 1986.

71. Brown, R.H., Jr., Johnson, D., Ogonowski, M., and H.L. Weiner: Anti neural antibodies in the serum of patients with amyotrophic lateral sclerosis. Neurology 37: 152–155, 1987.

72. Fallis, R.J., Harris, L., and H.L. Weiner: Serial analysis of peripheral blood T cell subsets and myelin basic protein reactivity in experimental allergic encephalomyelitis (EAE). Neurology 37: 719–723, 1987.

73. Brown, R.H., Jr., Johnson, D., Ogonowski, M., and H.L. Weiner: Type 1 human poliovirus binds to human synaptosomes. Ann. Neurol. 21: 64–70, 1987.

74. Fallis, R.J., Powers, M.L., Sy, M S., and H.L. Weiner: Adoptive transfer of murine chronic relapsing autoimmune encephalitis: analysis of basic protein reactive cells in lymphoid organs and nervous system of donor and recipient animals. J. Neuroimmunol. 14: 205–219, 1987.

75. Morimoto, C., Hafler, D.A., Letvin,N.L., Hagan, M., Daley, J., Weiner, H.L., and S.F. Schlossman: Selective loss of the suppressor inducer T cell subset in progressive multiple sclerosis. N. Engl. J. Med. 316: 67–72, 1987.

76. Hafler, D.A., and H.L. Weiner: In vivo labeling of peripheral blood T cells using monoclonal antibodies: rapid traffic into cerebrospinal fluid in multiple sclerosis. Ann. Neurol. 22: 90–93, 1987.

77. Hafler, D.A., Benjamin, D.S., Burks, J., and H.L. Weiner: Myelin basic protein reactivity of brain and cerebrospinal fluid derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis. J. Immunol. 139: 68–72, 1987.

78. Hauser, S.L., Che, M., Fallis, R.J., and H.L. Weiner: Immunoregulatory abnormalities induced by experimental reovirus infection: functional alterations in T cell subpopulations. Clin. Immunol. Immunopathol. 45: 481–490, 1987.

79. Hafler, D.A., Fox, A.D., Benjamin, D.S., Blue, M., and H.L. Weiner: Secondary immune amplification following live poliovirus immunization in humans. Clin. Immunol. Immunopathol. 44: 321–328, 1987.

80. Schluesener H.J., Sobel, R.A., Linnington C, and H.L. Weiner: A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J. Immunol. 139: 4016–4021, 1987.

81. Hafler, D.A., Duby, A.D., Lee, S.J., Benjamin, D.S., Seidman, J.G., and H.L. Weiner: Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with chronic progressive multiple sclerosis. J. Exp. Med. 167: 1313–1322, 1988.

82. Higgins, P.J., and H.L. Weiner: Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. J. Immunol. 140: 440–445, 1988.

83. Schluesener H.J., Sobel R.A., and H.L. Weiner: Demyelinating rat experimental allergic encephalomyelitis (EAE): Treatment with a monoclonal antibody against activated T cells. J. Neuroimmunol. 18: 341–351, 1988.

84. Johnson, D., Seeldrayers, P.A., and H.L. Weiner: The role of mast cells in demyelination. 1. myelin proteins are degraded by mast cell proteases and myelin basic protein and P2 can stimulate mast cell degranulation. Brain Res. 444: 195–198, 1988.

85. Sobel, R.A., Hafler, D.A., Castro, E.E., Morimoto, C, and H.L. Weiner: The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions. J Immunol. 140: 2210–2214, 1988.

86. Carter, J.L., Hafler, D.A., Dawson, D.M., Orav, J., and H.L. Weiner: Immunosuppression with high dose IV cyclophosphamide and ACTH in progressive multiple sclerosis: cummulative 6 year experience in 164 patients. Neurology 38(2): 9–14, 1988.

87. Hafler, D.A., Ritz, J., Schlossman, S.F., and H.L. Weiner: Anti CD4 and anti CD2 monoclonal antibodies infusions in humans: Immunosuppressive effects and human anti mouse responses. J. Immunol. 141: 131–138, 1988.

88. Chofflon, M., Morimoto C., Weiner, H.L., and D.A. Hafler: Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+2H4+) T cells in multiple sclerosis. Ann. Neurol. 24: 185–191, 1988.

89. Shepley, M.P., Sherry, B., and H.L. Weiner: Monoclonal antibody identification of a 100 kDa membrane protein in Hela cells and human spinal cord involved in poliovirus attachment. Proc. Natl. Acad. Sci. USA 85: 7743–7747, 1988.

90. Duby, A.D., Weiner, H.L., Benjamin, D.S., Seidman, J.G., and D.A. Hafler: Sequestration of virus specific T cells in the cerebrospinal fluid of a patient with herpes zoster viral meningoencephalitis. J. Neuroimmunol. 22: 63–68, 1989.

91. Lider, O., Santos, L.M.B., Lee, C.S.Y., Higgins, P.J., and H.L. Weiner: Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein II. Suppression of disease and in vitro immune responses is mediated by antigen specific CD8+ T lymphocytes. J. Immunol. 142: 748–752, 1989.

92. Hauser, S.L., Fleischnick, E., Weiner, H.L., Marcus, D., Awdeh, Z., Yunis, E.J., and C.A. Alper: Extended major histocompatibility complex haplotypes in patients with multiple sclerosis. Neurology 39: 275–277, 1989.

93. Chofflon, M., Weiner, H.L., Morimoto, C., and D.A. Hafler: Decrease of suppressor inducer (CD4+2H4+) T cells in multiple sclerosis cerebrospinal fluid. Ann. Neurol. 25: 494–499, 1989.

94. Weiner, H.L., Dau, P., Khatri, B., Petajan, J., Birnbaum, G., McQuillen, M., Fosburg, M., Feldstein, M., and J. Orav: Double blind study of true vs. sham plasma exchange in patients being treated with immunosuppression for acute attacks of multiple sclerosis. Neurology 39: 1143–1149, 1989.

95. Seeldrayers, P.A., Yasui, D., Weiner, H.L., and D. Johnson: Treatment of experimental allergic neuritis with nedrocromil sodium. J. Neuroimmunol. 25: 221–226, 1989.

96. Chofflon, M., Gonzalez, V., Weiner, H.L., and D.A. Hafler: Inflammatory cerebrospinal fluid T cells have activation requirements characteristic of CD4+CD45RA T cells. Eur. J. Immunol. 19: 1791–1795, 1989.