Henry Yim Wu, Ph.D.

Instructor in Neurology

Center for Neurologic Diseases
Brigham and Women's Hospital
77 Avenue Louis Pasteur, HIM-720
Boston, MA 02115

T: 617.525.5184
F: 617.525.5305
E: hwu@rics.bwh.harvard.edu


Education

1996 Bachelor of Science (Oxford, UK)
2000 Doctor of Philosophy (London, UK)

  Postdoctoral Training:

 2000-2002 Infection and Immunity Research Group, King¹s College London, UK.

Major research interests:

Mucosal tolerance as a form of therapeutic treatment for autoimmune diseases is the focal point of my research. Mucosal tolerance is an attractive alternative to conventional therapy because it has no or minimal side effects and is noninvasive. I am testing the efficacy of mucosal tolerance as a form of therapy in murine models of systemic lupus erythematosus, arthritis and Diabetes.

Publications:

Wu. H. Y., E. M. Center, G. C. Tsokos and H. L. Weiner. (2008) Oral anti-CD3 induces CD4+CD25-LAP+ regulatory T cells and suppresses murine SLE by downregulating pathogenic IL-17+CD4+ICOS+CXCR5+ follicular helper T cells.Lupus (submitted).

Wu, H. Y., F. J. Quintana and H. L. Weiner. (2008) Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10 secreting CD4+CD25-LAP+ regulatory T cell and is associated with downregulation of IL-17+CD4+ICOS+CXCR5+ follicular helper T cells. J. Immunol. (in press).

Wu, H. Y. (2008) Induction of mucosal tolerance in SLE: A sniff or a sip away from ameliorating lupus? Clin. Immunol. (in press).

Zhang, Z, V. C. Kyttaris, Z, Chen, H. Y. Wu and G. C. Tsokos. (2008) CTLA-4 expression regulation and its functions in systemic lupus erythematosus (SLE). FASEB. 22:667-9.

Ochi, H., M. Abraham, H. Ishikawa, D. Frenkel, H. Y. Wu et al and H. L. Weiner (2006) Oral administration of anti-CD3 antibody suppresses experimental allergic encephalomyelitis by inducing latency associatedpeptide (LAP)-positive regulatory T cells. Nat Med. 12:627-635.

Wu, H. Y., A. Monsonego, and H. L. Weiner. (2006) The mechanism of nasaltolerance in lupus prone mice is T cell anergy induced by immature B cells that lack B7 expression. J. Autoimmunity. 26:116-26.

Wu, H. Y., and N. A. Staines. (2004) A deficiency of CD4+CD25+ T cells permits the development of spontaneous lupus-like disease in mice, and can bereversed by induction of mucosal tolerance to histone peptide autoantigen.Lupus. 3:192-200.

Wu, H. Y., and H. L. Weiner. (2003) Oral tolerance. Immunol Res. 28:265-84.

Wu, H. Y., F. J. Ward, and N. A. Staines. (2002) Histone peptide-induced nasal tolerance: suppression of murine lupus. J. Immunol. 169:1126-1134.

Wu, H. Y., F. J. Ward, and N. A. Staines. (1999) Induction of tolerance inmurine SLE by nasal administration of a peptide representing an autoreactive T cell epitope in core histone protein H4. Arthritis. Rheumat. 42 9S): S363.