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Murugaiyan Gopal

Postdoctoral Fellow

Center for Neurologic Diseases
Brigham and Women's Hospital
77 Avenue Louis Pasteur,
Harvard Institutes of Medicine
Boston, MA 02115

T: 617-525-5324

E: gmurugaiyan@partners.org

Education & Research:

1996-1999 B.Sc  in Chemistry & Microbiology, Bharathidasan University, India.

1999-2002 M.Sc in Biochemistry, Annamalai University, India.

2002-2006 Ph.D in Biotechnology, National Centre for Cell Science, Pune University,   India.

2006-         Post doctoral fellow, Brigham and Women’s Hospital, Harvard Medical      School, Boston, USA.

Major research interests:                                   

  •     Immunology of Autoimmune Diseases.
  •     Tumor Immunology.

Publications:

  1. Murugaiyan G, Basak S, Saha B. Dendritic cell based immunotherapy: A promising approach for treatment of cancer. Gene Ther Mol Bio. 2005; 9: 343-358.2.
  1. Murugaiyan G, Basak S, Saha B. Reversal of tumor induced dendritic cell paralysis: A treatment regimen against cancer. Curr Immunol Rev. 2006: 2: 261-272.
  2. Murugaiyan G, Agrawal R, Mishra GC, Mitra D, Saha B. Functional dichotomy in CD40 reciprocally regulates effector T cell functions. J. Immunol. 2006; 177: 6642-9.
  1. Murugaiyan G, Agrawal R, Mishra GC, Mitra D, Saha B. Differential CD40/CD40L expression results in counteracting antitumor immune responses. J. Immunol. 2007; 178: 2047-55.
  2. Murugaiyan G, Martin S, Saha B. Levels of CD40 expression on dendritic cells dictate tumour growth or regression. Clin. Exp. Immunol. 2007; 149: 194-202.
  1. Balasubramaniyan V, Murugaiyan G, Shukla R, Bhonde RR, Nalini N. Leptin downregulates ethanol-induced secretion of proinflammatory cytokines and growth factor. Cytokine. 2007; 37: 96-100.
  2. Balasubramaniyan V, Shukla R, Murugaiyan G, Bhonde RR, Nalini N. Mouse recombinant leptin protects human hepatoma HepG2 against apoptosis, TNF-alpha response and oxidative stress induced by the hepatotoxin-ethanol. Biochim. Biophys. Acta. 2007; 1770: 1136-44.
  1. Murugaiyan G, Martin S, Saha B. CD40- induced countercurrent conduits for tumor escape or elimination. Trends Immunol. 2007; 28: 467-473.
  2. Vaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL, Weiner HL. Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. J Neuroimmunol. 2008; 195:140-5.