Publications – Weiner Laboratory

All Publications in PubMed

Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Prat A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ.Author Correction: Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 Sep;22(9):1533. doi: 10.1038/s41593-019-0446-8.

2	Fakih R, Diaz-Cruz C, Chua AS, Gonzalez C, Healy BC, Sattarnezhad N, Glanz BI, Weiner HL, Chitnis T.Food allergies are associated with increased disease activity in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2019 Jun;90(6):629-635. doi: 10.1136/jnnp-2018-319301. Epub 2018 Dec 18.

3	Liu G, Weiner HL, Pederson WC, Davies L, Buchanan EP.Beta-Catenin Mutation with Complex Chromosomal Changes in Desmoid Tumor of the Scalp: A Case Report. Craniomaxillofac Trauma Reconstr. 2019 Jun;12(2):146-149. doi: 10.1055/s-0038-1676078. Epub 2018 Nov 16.

Peroni S, Sorosina M, Malhotra S, Clarelli F, Osiceanu AM, Ferrè L, Roostaei T, Rio J, Midaglia L, Villar LM, Álvarez-Cermeño JC, Guaschino C, Radaelli M, Citterio L, Lechner-Scott J, Spataro N, Navarro A, Martinelli V, Montalban X, Weiner HL, de Jager P, Comi G, Esposito F, Comabella M, Martinelli-Boneschi F.A pharmacogenetic study implicates NINJ2 in the response to Interferon-? in multiple sclerosis. Mult Scler. 2019 Jun 21:1352458519851428. doi: 10.1177/1352458519851428. [Epub ahead of print].

Boden EK, Canavan JB, Moran CJ, McCann K, Dunn WA, Farraye FA, Ananthakrishnan AN, Yajnik V, Gandhi R, Nguyen DD, Bhan AK, Weiner HL, Korzenik JR, Snapper SB.Immunologic Alterations Associated With Oral Delivery of Anti-CD3 (OKT3) Monoclonal Antibodies in Patients With Moderate-to-Severe Ulcerative Colitis. Crohns Colitis 360. 2019 Jul;1(2):otz009. doi: 10.1093/crocol/otz009. Epub 2019 Jun 7.

Yano H, Gonzalez C, Healy BC, Glanz BI, Weiner HL, Chitnis T.Discontinuation of disease-modifying therapy for patients with relapsing-remitting multiple sclerosis: Effect on clinical and MRI outcomes. Mult Scler Relat Disord. 2019 Jul 25;35:119-127. doi: 10.1016/j.msard.2019.07.021. [Epub ahead of print].

Singhal T, O''Connor K, Dubey S, Pan H, Chu R, Hurwitz S, Cicero S, Tauhid S, Silbersweig D, Stern E, Kijewski M, DiCarli M, Weiner HL, Bakshi R.Gray matter microglial activation in relapsing vs progressive MS: A [F-18]PBR06-PET study. Neurol Neuroimmunol Neuroinflamm. 2019 Jul 1;6(5):e587. doi: 10.1212/NXI.0000000000000587. eCollection 2019 Sep.

Singhal T, O''Connor K, Dubey S, Pan H, Chu R, Hurwitz S, Cicero S, Tauhid S, Silbersweig D, Stern E, Kijewski M, DiCarli M, Weiner HL, Bakshi R.Gray matter microglial activation in relapsing vs progressive MS: A [F-18]PBR06-PET study. Neurol Neuroimmunol Neuroinflamm. 2019 Jul 1;6(5). pii: e587. doi: 10.1212/NXI.0000000000000587. Print 2019 Sep.

Mazzola MA, Raheja R, Regev K, Beynon V, von Glehn F, Paul A, Pierre I, Kivisakk P, Weiner HL, Gandhi R.Monomethyl fumarate treatment impairs maturation of human myeloid dendritic cells and their ability to activate T cells. Mult Scler. 2019 Jan;25(1):63-71. doi: 10.1177/1352458517740213. Epub 2017 Nov 6.

10	Aschenbrenner D, Foglierini M, Jarrossay D, Hu D, Weiner HL, Kuchroo VK, Lanzavecchia A, Notarbartolo S, Sallusto F.Publisher Correction: An immunoregulatory and tissue-residency program modulated by c-MAF in human T_H17 cells. Nat Immunol. 2019 Jan;20(1):109. doi: 10.1038/s41590-018-0264-2.

Moreira TG, Horta LS, Gomes-Santos AC, Oliveira RP, Queiroz NMGP, Mangani D, Daniel B, Vieira AT, Liu S, Rodrigues AM, Gomes DA, Gabriely G, Ferreira E, Weiner HL, Rezende RM, Nagy L, Faria AMC.CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-?-producing macrophages and T cells. Mucosal Immunol. 2019 Jan;12(1):188-199. doi: 10.1038/s41385-018-0090-8. Epub 2018 Oct 2.

12	Hemond CC, Healy BC, Tauhid S, Mazzola MA, Quintana FJ, Gandhi R, Weiner HL, Bakshi R.MRI phenotypes in MS: Longitudinal changes and miRNA signatures. Neurol Neuroimmunol Neuroinflamm. 2019 Feb 14;6(2):e530. doi: 10.1212/NXI.0000000000000530. eCollection 2019 Mar.

13	Rezende RM, Lopes ME, Menezes GB, Weiner HL.Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy. J Vis Exp. 2019 Aug 9;(150). doi: 10.3791/59335.

14	Gonzalez CG, Tankou SK, Cox LM, Casavant EP, Weiner HL, Elias JE.Latent-period stool proteomic assay of multiple sclerosis model indicates protective capacity of host-expressed protease inhibitors. Sci Rep. 2019 Aug 28;9(1):12460. doi: 10.1038/s41598-019-48495-5.

Palotai M, Cavallari M, Koubiyr I, Morales Pinzon A, Nazeri A, Healy BC, Glanz B, Weiner HL, Chitnis T, Guttmann CR.Microstructural fronto-striatal and temporo-insular alterations are associated with fatigue in patients with multiple sclerosis independent of white matter lesion load and depression. Mult Scler. 2019 Aug 16:1352458519869185. doi: 10.1177/1352458519869185. [Epub ahead of print].

16	Zurawski J, Glanz BI, Healy BC, Tauhid S, Khalid F, Chitnis T, Weiner HL, Bakshi R.The impact of cervical spinal cord atrophy on quality of life in multiple sclerosis. J Neurol Sci. 2019 Aug 15;403:38-43. doi: 10.1016/j.jns.2019.04.023. Epub 2019 Apr 18.

17	Cox LM, Abou-El-Hassan H, Maghzi AH, Vincentini J, Weiner HL.The sex-specific interaction of the microbiome in neurodegenerative diseases. Brain Res. 2019 Aug 13;1724:146385. doi: 10.1016/j.brainres.2019.146385. [Epub ahead of print] Review.

18	Dempsey RF, Chelius DC Jr, Pederson WC, Maricevich M, Dimachkieh AL, Kupferman ME, Weiner HL, Hollier LH Jr, Buchanan EP.Pediatric Craniomaxillofacial Oncologic Reconstruction. Clin Plast Surg. 2019 Apr;46(2):261-273. doi: 10.1016/j.cps.2018.11.011. Epub 2019 Jan 30. Review.

Das S; Extracellular RNA Communication Consortium, Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, Saugstad JA, Van Keuren-Jensen K, Weaver AM, Laurent LC.The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research. Cell. 2019 Apr 4;177(2):231-242. doi: 10.1016/j.cell.2019.03.023. Review.

20	Rezende RM, Weiner HL.Cellular Components and Mechanisms of Oral Tolerance Induction. Crit Rev Immunol. 2018;38(3):207-231. doi: 10.1615/CritRevImmunol.2018026181. Review.

Singhal T, O?Connor K, Dubey S, Belanger AP, Hurwitz S, Chu R, Tauhid S, Kijewski MF, DiCarli MF, Weiner HL, Bakshi R.18F-PBR06 Versus 11C-PBR28 PET for Assessing White Matter Translocator Protein Binding in Multiple Sclerosis. Clin Nucl Med. 2018 Sep;43(9):e289-e295. doi: 10.1097/RLU.0000000000002179.

22	Lu DS, Karas PJ, Krueger DA, Weiner HL.Central nervous system manifestations of tuberous sclerosis complex. Am J Med Genet C Semin Med Genet. 2018 Sep;178(3):291-298. doi: 10.1002/ajmg.c.31647. Epub 2018 Sep 19. Review.

Bove R, Chitnis T, Cree BA, Tintorè M, Naegelin Y, Uitdehaag BM, Kappos L, Khoury SJ, Montalban X, Hauser SL, Weiner HL; SUMMIT Consortium.SUMMIT (Serially Unified Multicenter Multiple Sclerosis Investigation): creating a repository of deeply phenotyped contemporary multiple sclerosis cohorts. Mult Scler. 2018 Oct;24(11):1485-1498. doi: 10.1177/1352458517726657. Epub 2017 Aug 29.

24	Butovsky O, Weiner HL.Microglial signatures and their role in health and disease. Nat Rev Neurosci. 2018 Oct;19(10):622-635. doi: 10.1038/s41583-018-0057-5. Review.

Wray S, Havrdova E, Snydman DR, Arnold DL, Cohen JA, Coles AJ, Hartung HP, Selmaj KW, Weiner HL, Daizadeh N, Margolin DH, Chirieac MC, Compston DAS.Infection risk with alemtuzumab decreases over time: pooled analysis of 6-year data from the CAMMS223, CARE-MS I, and CARE-MS II studies and the CAMMS03409 extension study. Mult Scler. 2018 Oct 5:1352458518796675. doi: 10.1177/1352458518796675. [Epub ahead of print].

Chitnis T, Gonzalez C, Healy BC, Saxena S, Rosso M, Barro C, Michalak Z, Paul A, Kivisakk P, Diaz-Cruz C, Sattarnezhad N, Pierre IV, Glanz BI, Tomic D, Kropshofer H, Häring D, Leppert D, Kappos L, Bakshi R, Weiner HL, Kuhle J.Neurofilament light chain serum levels correlate with 10-year MRI outcomes in multiple sclerosis. Ann Clin Transl Neurol. 2018 Oct 16;5(12):1478-1491. doi: 10.1002/acn3.638. eCollection 2018 Dec.

27	Kuzniecky R, Baez C, Aranda G, Hidalgo ET, Grover A, Orillac C, Zelenka Y, Weiner HL.Epilepsy surgery in Panama: Establishment of a successful hybrid program as a model for small middle-income countries. Epilepsia. 2018 Nov;59(11):2137-2144. doi: 10.1111/epi.14571. Epub 2018 Oct 19.

28	Zrzavy T, Machado-Santos J, Christine S, Baumgartner C, Weiner HL, Butovsky O, Lassmann H.Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts. Brain Pathol. 2018 Nov;28(6):791-805. doi: 10.1111/bpa.12583. Epub 2017 Dec 28.

Rubino SJ, Mayo L, Wimmer I, Siedler V, Brunner F, Hametner S, Madi A, Lanser A, Moreira T, Donnelly D, Cox L, Rezende RM, Butovsky O, Lassmann H, Weiner HL.Acute microglia ablation induces neurodegeneration in the somatosensory system. Nat Commun. 2018 Nov 1;9(1):4578. doi: 10.1038/s41467-018-05929-4.

30	Healy BC, Zurawski J, Gonzalez CT, Chitnis T, Weiner HL, Glanz BI.Assessment of computer adaptive testing version of the Neuro-QOL for people with multiple sclerosis. Mult Scler. 2018 Nov 1:1352458518810159. doi: 10.1177/1352458518810159. [Epub ahead of print].

31	Healy BC, Glanz BI, Zurawski JD, Mazzola M, Chitnis T, Weiner HL.Long-term follow-up for multiple sclerosis patients initially treated with interferon-beta and glatiramer acetate. J Neurol Sci. 2018 Nov 15;394:127-131. doi: 10.1016/j.jns.2018.09.020. Epub 2018 Sep 17.

32	Tankou SK, Regev K, Healy BC, Tjon E, Laghi L, Cox LM, Kivisäkk P, Pierre IV, Hrishikesh L, Gandhi R, Cook S, Glanz B, Stankiewicz J, Weiner HL.A probiotic modulates the microbiome and immunity in multiple sclerosis. Ann Neurol. 2018 Jun;83(6):1147-1161. doi: 10.1002/ana.25244. Epub 2018 Jun 8.

33	Dastagir A, Healy BC, Chua AS, Chitnis T, Weiner HL, Bakshi R, Tauhid S.Brain and spinal cord MRI lesions in primary progressive vs. relapsing-remitting multiple sclerosis. eNeurologicalSci. 2018 Jul 4;12:42-46. doi: 10.1016/j.ensci.2018.07.002. eCollection 2018 Sep.

Okunuki Y, Mukai R, Pearsall EA, Klokman G, Husain D, Park DH, Korobkina E, Weiner HL, Butovsky O, Ksander BR, Miller JW, Connor KM.Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6264-E6273. doi: 10.1073/pnas.1719601115. Epub 2018 Jun 18.

35	Meier DS, Guttmann CRG, Tummala S, Moscufo N, Cavallari M, Tauhid S, Bakshi R, Weiner HL.Dual-Sensitivity Multiple Sclerosis Lesion and CSF Segmentation for Multichannel 3T Brain MRI. J Neuroimaging. 2018 Jan;28(1):36-47. doi: 10.1111/jon.12491. Epub 2017 Dec 13.

36	Cox LM, Weiner HL.Microbiota Signaling Pathways that Influence Neurologic Disease. Neurotherapeutics. 2018 Jan;15(1):135-145. doi: 10.1007/s13311-017-0598-8. Review.

Miller DH, Lublin FD, Sormani MP, Kappos L, Yaldizli Õ, Freedman MS, Cree BAC, Weiner HL, Lubetzki C, Hartung HP, Montalban X, Uitdehaag BMJ, MacManus DG, Yousry TA, Gandini Wheeler-Kingshott CAM, Li B, Putzki N, Merschhemke M, Häring DA, Wolinsky JS.Brain atrophy and disability worsening in primary progressive multiple sclerosis: insights from the INFORMS study. Ann Clin Transl Neurol. 2018 Jan 30;5(3):346-356. doi: 10.1002/acn3.534. eCollection 2018 Mar.

Baharnoori M, Gonzalez CT, Chua A, Diaz-Cruz C, Healy BC, Stankiewicz J, Weiner HL, Chitnis T.Predictors of hematological abnormalities in multiple sclerosis patients treated with fingolimod and dimethyl fumarate and impact of treatment switch on lymphocyte and leukocyte count. Mult Scler Relat Disord. 2018 Feb;20:51-57. doi: 10.1016/j.msard.2017.12.003. Epub 2017 Dec 14.

39	Baecher-Allan C, Kaskow BJ, Weiner HL.Multiple Sclerosis: Mechanisms and Immunotherapy. Neuron. 2018 Feb 21;97(4):742-768. doi: 10.1016/j.neuron.2018.01.021. Review.

Hidalgo ET, Frankel HG, Rodriguez C, Orillac C, Phillips S, Patel N, Devinsky O, Friedman D, Weiner HL.Invasive monitoring after resection of epileptogenic neocortical lesions in multistaged epilepsy surgery in children. Epilepsy Res. 2018 Dec;148:48-54. doi: 10.1016/j.eplepsyres.2018.09.001. Epub 2018 Sep 19.

Raheja R, Regev K, Healy BC, Mazzola MA, Beynon V, Von Glehn F, Paul A, Diaz-Cruz C, Gholipour T, Glanz BI, Kivisakk P, Chitnis T, Weiner HL, Berry JD, Gandhi R.Correlating serum micrornas and clinical parameters in amyotrophic lateral sclerosis. Muscle Nerve. 2018 Aug;58(2):261-269. doi: 10.1002/mus.26106. Epub 2018 Mar 25.

42	Rezende RM, Lanser AJ, Rubino S, Kuhn C, Skillin N, Moreira TG, Liu S, Gabriely G, David BA, Menezes GB, Weiner HL.?? T cells control humoral immune response by inducing T follicular helper cell differentiation. Nat Commun. 2018 Aug 8;9(1):3151. doi: 10.1038/s41467-018-05487-9.

Regev K, Healy BC, Paul A, Diaz-Cruz C, Mazzola MA, Raheja R, Glanz BI, Kivisäkk P, Chitnis T, Jagodic M, Piehl F, Olsson T, Khademi M, Hauser S, Oksenberg J, Khoury SJ, Weiner HL, Gandhi R.Identification of MS-specific serum miRNAs in an international multicenter study. Neurol Neuroimmunol Neuroinflamm. 2018 Aug 20;5(5):e491. doi: 10.1212/NXI.0000000000000491. eCollection 2018 Sep.

Wimmer I, Tröscher AR, Brunner F, Rubino SJ, Bien CG, Weiner HL, Lassmann H, Bauer J.Systematic evaluation of RNA quality, microarray data reliability and pathway analysis in fresh, fresh frozen and formalin-fixed paraffin-embedded tissue samples. Sci Rep. 2018 Apr 20;8(1):6351. doi: 10.1038/s41598-018-24781-6.

45	Healy BC, Buckle GJ, Ali EN, Egorova S, Khalid F, Tauhid S, Glanz BI, Chitnis T, Guttmann CRG, Weiner HL, Bakshi R.Characterizing Clinical and MRI Dissociation in Patients with Multiple Sclerosis. J Neuroimaging. 2017 Sep;27(5):481-485. doi: 10.1111/jon.12433. Epub 2017 Mar 6.

Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O''Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich JD, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner FL, Litvak V, Holtzman DM, Lassmann H, Weiner HL, Ochando J, Haass C, Butovsky O.The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 2017 Sep 19;47(3):566-581.e9. doi: 10.1016/j.immuni.2017.08.008.

47	Singhal T, Weiner HL, Bakshi R.TSPO-PET Imaging to Assess Cerebral Microglial Activation in Multiple Sclerosis. Semin Neurol. 2017 Oct;37(5):546-557. doi: 10.1055/s-0037-1608715. Epub 2017 Dec 5. Review.

Ogura M, Deng S, Preston-Hurlburt P, Ogura H, Shailubhai K, Kuhn C, Weiner HL, Herold KC.Oral treatment with foralumab, a fully human anti-CD3 monoclonal antibody, prevents skin xenograft rejection in humanized mice. Clin Immunol. 2017 Oct;183:240-246. doi: 10.1016/j.clim.2017.07.005. Epub 2017 Jul 21.

Diaz-Cruz C, Chua AS, Malik MT, Kaplan T, Glanz BI, Egorova S, Guttmann CRG, Bakshi R, Weiner HL, Healy BC, Chitnis T.The effect of alcohol and red wine consumption on clinical and MRI outcomes in multiple sclerosis. Mult Scler Relat Disord. 2017 Oct;17:47-53. doi: 10.1016/j.msard.2017.06.011. Epub 2017 Jun 27.

50	Whitman L, Scharaga EA, Blackmon K, Wiener J, Bender HA, Weiner HL, MacAllister WS.Material specificity of memory deficits in children with temporal tumors and seizures: A case series. Appl Neuropsychol Child. 2017 Oct-Dec;6(4):335-344. doi: 10.1080/21622965.2016.1197126. Epub 2016 Jul 1.

51	Chitnis T, Weiner HL.CNS inflammation and neurodegeneration. J Clin Invest. 2017 Oct 2;127(10):3577-3587. doi: 10.1172/JCI90609. Epub 2017 Sep 5.

52	Weiner HL, Placantonakis DG.Resection of a Pediatric Thalamic Juvenile Pilocytic Astrocytoma with Whole Brain Tractography. Cureus. 2017 Oct 11;9(10):e1768. doi: 10.7759/cureus.1768.

Eagle T, Stuart F, Chua AS, LaRussa A, Leclaire K, Cook SL, Chitnis T, Weiner HL, Glanz BI, Healy BC.Treatment satisfaction across injectable, infusion, and oral disease-modifying therapies for multiple sclerosis. Mult Scler Relat Disord. 2017 Nov;18:196-201. doi: 10.1016/j.msard.2017.10.002. Epub 2017 Oct 5.

Kim G, Chu R, Yousuf F, Tauhid S, Stazzone L, Houtchens MK, Stankiewicz JM, Severson C, Kimbrough D, Quintana FJ, Chitnis T, Weiner HL, Healy BC, Bakshi R.Sample size requirements for one-year treatment effects using deep gray matter volume from 3T MRI in progressive forms of multiple sclerosis. Int J Neurosci. 2017 Nov;127(11):971-980. doi: 10.1080/00207454.2017.1283313. Epub 2017 Feb 2.

Hu D, Notarbartolo S, Croonenborghs T, Patel B, Cialic R, Yang TH, Aschenbrenner D, Andersson KM, Gattorno M, Pham M, Kivisakk P, Pierre IV, Lee Y, Kiani K, Bokarewa M, Tjon E, Pochet N, Sallusto F, Kuchroo VK, Weiner HL.Transcriptional signature of human pro-inflammatory T_H17 cells identifies reduced IL10 gene expression in multiple sclerosis. Nat Commun. 2017 Nov 17;8(1):1600. doi: 10.1038/s41467-017-01571-8.

56	Saad TF, Weiner HL.Venous Hemodialysis Catheters and Cardiac Implantable Electronic Devices: Avoiding a High-Risk Combination. Semin Dial. 2017 May;30(3):187-192. doi: 10.1111/sdi.12581. Epub 2017 Feb 23.

57	Khalid F, Tauhid S, Chua AS, Healy BC, Stankiewicz JM, Weiner HL, Bakshi R.A longitudinal uncontrolled study of cerebral gray matter volume in patients receiving natalizumab for multiple sclerosis. Int J Neurosci. 2017 May;127(5):396-403. doi: 10.1080/00207454.2016.1185421. Epub 2016 May 27.

Gabriely G, da Cunha AP, Rezende RM, Kenyon B, Madi A, Vandeventer T, Skillin N, Rubino S, Garo L, Mazzola MA, Kolypetri P, Lanser AJ, Moreira T, Faria AMC, Lassmann H, Kuchroo V, Murugaiyan G, Weiner HL.Targeting latency-associated peptide promotes antitumor immunity. Sci Immunol. 2017 May 19;2(11). pii: eaaj1738. doi: 10.1126/sciimmunol.aaj1738.

59	Hidalgo ET, Weiner HL.Surgery for epileptogenic cerebral dysplasia in children. Dev Med Child Neurol. 2017 Mar;59(3):270-275. doi: 10.1111/dmcn.13292. Epub 2016 Oct 11. Review.

Andersson KM, Turkkila M, Erlandsson MC, Bossios A, Silfverswärd ST, Hu D, Ekerljung L, Malmhäll C, Weiner HL, Lundbäck B, Bokarewa MI.Survivin controls biogenesis of microRNA in smokers: A link to pathogenesis of rheumatoid arthritis. Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):663-673. doi: 10.1016/j.bbadis.2016.11.033. Epub 2016 Dec 1.

Regev K, Healy BC, Khalid F, Paul A, Chu R, Tauhid S, Tummala S, Diaz-Cruz C, Raheja R, Mazzola MA, von Glehn F, Kivisakk P, Dupuy SL, Kim G, Chitnis T, Weiner HL, Gandhi R, Bakshi R.Association Between Serum MicroRNAs and Magnetic Resonance Imaging Measures of Multiple Sclerosis Severity. JAMA Neurol. 2017 Mar 1;74(3):275-285. doi: 10.1001/jamaneurol.2016.5197.

Rothhammer V, Borucki DM, Garcia Sanchez MI, Mazzola MA, Hemond CC, Regev K, Paul A, Kivisäkk P, Bakshi R, Izquierdo G, Weiner HL, Quintana FJ.Dynamic regulation of serum aryl hydrocarbon receptor agonists in MS. Neurol Neuroimmunol Neuroinflamm. 2017 Jun 16;4(4):e359. doi: 10.1212/NXI.0000000000000359. eCollection 2017 Jul.

63	Zrzavy T, Hametner S, Wimmer I, Butovsky O, Weiner HL, Lassmann H.Loss of ''homeostatic'' microglia and patterns of their activation in active multiple sclerosis. Brain. 2017 Jul 1;140(7):1900-1913. doi: 10.1093/brain/awx113.

Kuhn C, Rezende RM, da Cunha AP, Valette F, Quintana FJ, Chatenoud L, Weiner HL.Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain. J Autoimmun. 2017 Jan;76:115-122. doi: 10.1016/j.jaut.2016.10.001. Epub 2016 Oct 10.

65	Hidalgo ET, Orillac C, Hersh A, Harter DH, Rizzo WB, Weiner HL.Intrathecal Baclofen Therapy for the Treatment of Spasticity in Sj�gren-Larsson Syndrome. J Child Neurol. 2017 Jan;32(1):100-103. doi: 10.1177/0883073816671440. Epub 2016 Oct 6.

66	Kuhn C, Rezende RM, M''Hamdi H, da Cunha AP, Weiner HL.IL-6 Inhibits Upregulation of Membrane-Bound TGF-? 1 on CD4+ T Cells and Blocking IL-6 Enhances Oral Tolerance. J Immunol. 2017 Feb 1;198(3):1202-1209. doi: 10.4049/jimmunol.1600921. Epub 2016 Dec 30.

67	Lanser AJ, Rezende RM, Rubino S, Lorello PJ, Donnelly DJ, Xu H, Lau LA, Dulla CG, Caldarone BJ, Robson SC, Weiner HL.Disruption of the ATP/adenosine balance in CD39^-/- mice is associated with handling-induced seizures. Immunology. 2017 Dec;152(4):589-601. doi: 10.1111/imm.12798. Epub 2017 Aug 25.

Yousuf F, Dupuy SL, Tauhid S, Chu R, Kim G, Tummala S, Khalid F, Weiner HL, Chitnis T, Healy BC, Bakshi R.A two-year study using cerebral gray matter volume to assess the response to fingolimod therapy in multiple sclerosis. J Neurol Sci. 2017 Dec 15;383:221-229. doi: 10.1016/j.jns.2017.10.019. Epub 2017 Oct 16.

Katz JS, Frankel H, Ma T, Zagzag D, Liechty B, Zeev BB, Tzadok M, Devinsky O, Weiner HL, Roth J.Unique findings of subependymal giant cell astrocytoma within cortical tubers in patients with tuberous sclerosis complex: a histopathological evaluation. Childs Nerv Syst. 2017 Apr;33(4):601-607. doi: 10.1007/s00381-017-3335-z. Epub 2017 Jan 10.

70	Rezende RM, Weiner HL.History and mechanisms of oral tolerance. Semin Immunol. 2017 Apr;30:3-11. doi: 10.1016/j.smim.2017.07.004. Epub 2017 Jul 31. Review.

71	Zhao Y, Healy BC, Rotstein D, Guttmann CR, Bakshi R, Weiner HL, Brodley CE, Chitnis T.Exploration of machine learning techniques in predicting multiple sclerosis disease course. PLoS One. 2017 Apr 5;12(4):e0174866. doi: 10.1371/journal.pone.0174866. eCollection 2017.

Bar-Or A, Steinman L, Behne JM, Benitez-Ribas D, Chin PS, Clare-Salzler M, Healey D, Kim JI, Kranz DM, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei CH, Weiner HL, Zamvil SS, Smith TJ, Yeaman MR.Restoring immune tolerance in neuromyelitis optica: Part II. Neurol Neuroimmunol Neuroinflamm. 2016 Sep 7;3(5):e277. doi: 10.1212/NXI.0000000000000277. eCollection 2016 Oct. Review.

Steinman L, Bar-Or A, Behne JM, Benitez-Ribas D, Chin PS, Clare-Salzler M, Healey D, Kim JI, Kranz DM, Lutterotti A, Martin R, Schippling S, Villoslada P, Wei CH, Weiner HL, Zamvil SS, Yeaman MR, Smith TJ.Restoring immune tolerance in neuromyelitis optica: Part I. Neurol Neuroimmunol Neuroinflamm. 2016 Sep 7;3(5):e276. doi: 10.1212/NXI.0000000000000276. eCollection 2016 Oct. Review.

Arnold DL, Fisher E, Brinar VV, Cohen JA, Coles AJ, Giovannoni G, Hartung HP, Havrdova E, Selmaj KW, Stojanovic M, Weiner HL, Lake SL, Margolin DH, Thomas DR, Panzara MA, Compston DA; CARE-MS I and CARE-MS II Investigators.Superior MRI outcomes with alemtuzumab compared with subcutaneous interferon ?-1a in MS. Neurology. 2016 Oct 4;87(14):1464-1472. Epub 2016 Sep 2.

Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S, Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ.AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. Cell Rep. 2016 Oct 25;17(5):1318-1329. doi: 10.1016/j.celrep.2016.09.082.

76	Weiner HL.Editorial: Hypothalamic hamartomas. J Neurosurg. 2016 May;124(5):1501-2. doi: 10.3171/2015.5.JNS15785. Epub 2015 Nov 20.

77	Rezende RM, Weiner HL.Inducing tolerance one antigen at a time. Nat Biotechnol. 2016 May 6;34(5):515-7. doi: 10.1038/nbt.3573.

78	Hidalgo ET, Ali A, Weiner HL, Harter DH.Resection of Intraventricular Tumors in Children by Purely Endoscopic Means. World Neurosurg. 2016 Mar;87:372-80. doi: 10.1016/j.wneu.2015.11.052. Epub 2015 Dec 17.

Oommen VV, Tauhid S, Healy BC, Chua AS, Malik MT, Diaz-Cruz C, Dupuy SL, Weiner HL, Chitnis T, Bakshi R.The Effect of Fingolimod on Conversion of Acute Gadolinium-Enhancing Lesions to Chronic T1 Hypointensities in Multiple Sclerosis. J Neuroimaging. 2016 Mar-Apr;26(2):184-7. doi: 10.1111/jon.12307. Epub 2015 Oct 8.

80	Liu S, Weiner HL.Control of the gut microbiome by fecal microRNA. Microb Cell. 2016 Mar 9;3(4):176-177. doi: 10.15698/mic2016.04.492.

Jangi S, Gandhi R, Cox LM, Li N, von Glehn F, Yan R, Patel B, Mazzola MA, Liu S, Glanz BL, Cook S, Tankou S, Stuart F, Melo K, Nejad P, Smith K, Topçuolu BD, Holden J, Kivisäkk P, Chitnis T, De Jager PL, Quintana FJ, Gerber GK, Bry L, Weiner HL.Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016 Jun 28;7:12015. doi: 10.1038/ncomms12015.

82	Kuhn C, Weiner HL.Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside. Immunotherapy. 2016 Jul;8(8):889-906. doi: 10.2217/imt-2016-0049. Epub 2016 May 10. Review.

Sahin M, Henske EP, Manning BD, Ess KC, Bissler JJ, Klann E, Kwiatkowski DJ, Roberds SL, Silva AJ, Hillaire-Clarke CS, Young LR, Zervas M, Mamounas LA; Tuberous Sclerosis Complex Working Group to Update the Research Plan.Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr Neurol. 2016 Jul;60:1-12. doi: 10.1016/j.pediatrneurol.2016.03.015. Epub 2016 Apr 2.

Mayo L, Cunha AP, Madi A, Beynon V, Yang Z, Alvarez JI, Prat A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL.IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation. Brain. 2016 Jul;139(Pt 7):1939-57. doi: 10.1093/brain/aww113. Epub 2016 May 31.

Bakshi R, Yeste A, Patel B, Tauhid S, Tummala S, Rahbari R, Chu R, Regev K, Kivisäkk P, Weiner HL, Quintana FJ.Serum lipid antibodies are associated with cerebral tissue damage in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016 Jan 27;3(2):e200. doi: 10.1212/NXI.0000000000000200. eCollection 2016 Apr.

86	Liu S, da Cunha AP, Rezende RM, Cialic R, Wei Z, Bry L, Comstock LE, Gandhi R, Weiner HL.The Host Shapes the Gut Microbiota via Fecal MicroRNA. Cell Host Microbe. 2016 Jan 13;19(1):32-43. doi: 10.1016/j.chom.2015.12.005.

Xia Z, White CC, Owen EK, Von Korff A, Clarkson SR, McCabe CA, Cimpean M, Winn PA, Hoesing A, Steele SU, Cortese IC, Chitnis T, Weiner HL, Reich DS, Chibnik LB, De Jager PL.Genes and Environment in Multiple Sclerosis project: A platform to investigate multiple sclerosis risk. Ann Neurol. 2016 Feb;79(2):178-89. doi: 10.1002/ana.24560. Epub 2015 Dec 9.

88	Kuhn C, Weiner HL.Immunology. How does the immune system tolerate food? Science. 2016 Feb 19;351(6275):810-1. doi: 10.1126/science.aaf2167. Epub 2016 Feb 18.

Laroni A, Armentani E, Kerlero de Rosbo N, Ivaldi F, Marcenaro E, Sivori S, Gandhi R, Weiner HL, Moretta A, Mancardi GL, Uccelli A.Dysregulation of regulatory CD56(bright) NK cells/T cells interactions in multiple sclerosis. J Autoimmun. 2016 Aug;72:8-18. doi: 10.1016/j.jaut.2016.04.003. Epub 2016 May 4.

90	Murugaiyan G, Garo LP, Weiner HL.MicroRNA-21, T helper lineage and autoimmunity. Oncotarget. 2015;6(12):9644-5.

Fallah A, Rodgers SD, Weil AG, Vadera S, Mansouri A, Connolly MB, Major P, Ma T, Devinsky O, Weiner HL, Gonzalez-Martinez JA, Bingaman WE, Najm I, Gupta A, Ragheb J, Bhatia S, Steinbok P, Witiw CD, Widjaja E, Snead OC, Rutka JT.Resective Epilepsy Surgery for Tuberous Sclerosis in Children: Determining Predictors of Seizure Outcomes in a Multicenter Retrospective Cohort Study. Neurosurgery. 2015 Oct;77(4):517-24; discussion 524. doi: 10.1227/NEU.0000000000000875.

92	Starossom SC, Veremeyko T, Yung AW, Dukhinova M, Au C, Lau AY, Weiner HL, Ponomarev ED.Platelets Play Differential Role During the Initiation and Progression of Autoimmune Neuroinflammation. Circ Res. 2015 Oct 9;117(9):779-92. doi: 10.1161/CIRCRESAHA.115.306847. Epub 2015 Aug 20.

93	Rotstein DL, Healy BC, Malik MT, Carruthers RL, Musallam AJ, Kivisakk P, Weiner HL, Glanz B, Chitnis T.Effect of vitamin D on MS activity by disease-modifying therapy class. Neurol Neuroimmunol Neuroinflamm. 2015 Oct 29;2(6):e167. doi: 10.1212/NXI.0000000000000167. eCollection 2015 Dec.

Chua AS, Egorova S, Anderson MC, Polgar-Turcsanyi M, Chitnis T, Weiner HL, Guttmann CR, Bakshi R, Healy BC.Using multiple imputation to efficiently correct cerebral MRI whole brain lesion and atrophy data in patients with multiple sclerosis. Neuroimage. 2015 Oct 1;119:81-8. doi: 10.1016/j.neuroimage.2015.06.037. Epub 2015 Jun 18.

Tauhid S, Chu R, Sasane R, Glanz BI, Neema M, Miller JR, Kim G, Signorovitch JE, Healy BC, Chitnis T, Weiner HL, Bakshi R.Brain MRI lesions and atrophy are associated with employment status in patients with multiple sclerosis. J Neurol. 2015 Nov;262(11):2425-32. doi: 10.1007/s00415-015-7853-x. Epub 2015 Jul 24.

96	Murugaiyan G, da Cunha AP, Ajay AK, Joller N, Garo LP, Kumaradevan S, Yosef N, Vaidya VS, Weiner HL.MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J Clin Invest. 2015 Mar 2;125(3):1069-80. doi: 10.1172/JCI74347. Epub 2015 Feb 2.

97	Grobelny BT, Weiner HL, Harter DH.Intramedullary spinal epidermoid presenting after thoracic meningocele repair: case report. J Neurosurg Pediatr. 2015 Jun;15(6):641-3. doi: 10.3171/2014.12.PEDS14270. Epub 2015 Mar 27.

Andersson KM, Cavallini NF, Hu D, Brisslert M, Cialic R, Valadi H, Erlandsson MC, Silfverswärd S, Pullerits R, Kuchroo VK, Weiner HL, Bokarewa MI.Pathogenic Transdifferentiation of Th17 Cells Contribute to Perpetuation of Rheumatoid Arthritis during Anti-TNF Treatment. Mol Med. 2015 Jun 4;21:536-43. doi: 10.2119/molmed.2015.00057.

Esposito F, Sorosina M, Ottoboni L, Lim ET, Replogle JM, Raj T, Brambilla P, Liberatore G, Guaschino C, Romeo M, Pertel T, Stankiewicz JM, Martinelli V, Rodegher M, Weiner HL, Brassat D, Benoist C, Patsopoulos NA, Comi G, Elyaman W, Martinelli Boneschi F, De Jager PL.A pharmacogenetic study implicates SLC9a9 in multiple sclerosis disease activity. Ann Neurol. 2015 Jul;78(1):115-27. doi: 10.1002/ana.24429. Epub 2015 May 14.

100

Chua AS, Egorova S, Anderson MC, Polgar-Turcsanyi M, Chitnis T, Weiner HL, Guttmann CR, Bakshi R, Healy BC.Handling changes in MRI acquisition parameters in modeling whole brain lesion volume and atrophy data in multiple sclerosis subjects: Comparison of linear mixed-effect models. Neuroimage Clin. 2015 Jul 2;8:606-10. doi: 10.1016/j.nicl.2015.06.009. eCollection 2015.

101	Rotstein DL, Healy BC, Malik MT, Chitnis T, Weiner HL.Evaluation of no evidence of disease activity in a 7-year longitudinal multiple sclerosis cohort. JAMA Neurol. 2015 Feb;72(2):152-8. doi: 10.1001/jamaneurol.2014.3537.

102	da Cunha AP, Wu HY, Rezende RM, Vandeventer T, Weiner HL.In vivo anti-LAP mAb enhances IL-17/IFN-? responses and abrogates anti-CD3-induced oral tolerance. Int Immunol. 2015 Feb;27(2):73-82. doi: 10.1093/intimm/dxu083. Epub 2014 Sep 6.

103	Maron BJ, Weiner HL, Maron MS, Roberts WC.Surviving malignant hypertrophic cardiomyopathy with all major complications in a single patient. Am J Cardiol. 2015 Feb 1;115(3):402-4. doi: 10.1016/j.amjcard.2014.11.004. Epub 2014 Nov 13.

104

Rezende RM, da Cunha AP, Kuhn C, Rubino S, M''Hamdi H, Gabriely G, Vandeventer T, Liu S, Cialic R, Pinheiro-Rosa N, Oliveira RP, Gaublomme JT, Obholzer N, Kozubek J, Pochet N, Faria AMC, Weiner HL.Identification and characterization of latency-associated peptide-expressing ?? T cells. Nat Commun. 2015 Dec 8;6:8726. doi: 10.1038/ncomms9726.

105

Mazzola MA, Raheja R, Murugaiyan G, Rajabi H, Kumar D, Pertel T, Regev K, Griffin R, Aly L, Kivisakk P, Nejad P, Patel B, Gwanyalla N, Hei H, Glanz B, Chitnis T, Weiner HL, Gandhi R.Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation. J Neuroinflammation. 2015 Dec 30;12:245. doi: 10.1186/s12974-015-0460-z.

106

Quinn JF, Patel T, Wong D, Das S, Freedman JE, Laurent LC, Carter BS, Hochberg F, Van Keuren-Jensen K, Huentelman M, Spetzler R, Kalani MY, Arango J, Adelson PD, Weiner HL, Gandhi R, Goilav B, Putterman C, Saugstad JA.Extracellular RNAs: development as biomarkers of human disease. J Extracell Vesicles. 2015 Aug 28;4:27495. doi: 10.3402/jev.v4.27495. eCollection 2015.

107

Laurent LC, Abdel-Mageed AB, Adelson PD, Arango J, Balaj L, Breakefield X, Carlson E, Carter BS, Majem B, Chen CC, Cocucci E, Danielson K, Courtright A, Das S, Abd Elmageed ZY, Enderle D, Ezrin A, Ferrer M, Freedman J, Galas D, Gandhi R, Huentelman MJ, Van Keuren-Jensen K, Kalani Y, Kim Y, Krichevsky AM, Lai C, Lal-Nag M, Laurent CD, Leonardo T, Li F, Malenica I, Mondal D, Nejad P, Patel T, Raffai RL, Rubio R, Skog J, Spetzler R, Sun J, Tanriverdi K, Vickers K, Wang L, Wang Y, Wei Z, Weiner HL, Wong D, Yan IK, Yeri A, Gould S.Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. J Extracell Vesicles. 2015 Aug 28;4:26533. doi: 10.3402/jev.v4.26533. eCollection 2015.

108

Sosunov AA, McGovern RA, Mikell CB, Wu X, Coughlin DG, Crino PB, Weiner HL, Ghatan S, Goldman JE, McKhann GM 2nd.Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities. Acta Neuropathol Commun. 2015 Apr 2;3:17. doi: 10.1186/s40478-015-0191-5.

109	Glanz BI, Musallam A, Rintell DJ, Chitnis T, Weiner HL, Healy BC.Treatment satisfaction in multiple sclerosis. Int J MS Care. 2014 Summer;16(2):68-75. doi: 10.7224/1537-2073.2013-021.

110	Carruthers RL, Rotstein DL, Healy BC, Chitnis T, Weiner HL, Buckle GJ.An observational comparison of natalizumab vs. fingolimod using JCV serology to determine therapy. Mult Scler. 2014 Sep;20(10):1381-90. doi: 10.1177/1352458514535282. Epub 2014 May 22.

111

Mycko MP, Weiner HL, Selmaj KW.Insights into multiple sclerosis provided by non-coding RNAs: meeting summary from the symposium ''non-coding RNAs in autoimmune disorders of the central nervous system'' on 5 April 2013 in Warsaw, Poland. Mult Scler. 2014 Oct;20(11):1439-42. doi: 10.1177/1352458514521518. Epub 2014 Feb 19.

112

Mayo L, Trauger SA, Blain M, Nadeau M, Patel B, Alvarez JI, Mascanfroni ID, Yeste A, Kivisäkk P, Kallas K, Ellezam B, Bakshi R, Prat A, Antel JP, Weiner HL, Quintana FJ.Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation. Nat Med. 2014 Oct;20(10):1147-56. doi: 10.1038/nm.3681. Epub 2014 Sep 14.

113

Bakshi R, Neema M, Tauhid S, Healy BC, Glanz BI, Kim G, Miller J, Berkowitz JL, Bove R, Houtchens MK, Severson C, Stankiewicz JM, Stazzone L, Chitnis T, Guttmann CR, Weiner HL, Ceccarelli A.An expanded composite scale of MRI-defined disease severity in multiple sclerosis: MRDSS2. Neuroreport. 2014 Oct 1;25(14):1156-61. doi: 10.1097/WNR.0000000000000244.

114	Tauhid S, Neema M, Healy BC, Weiner HL, Bakshi R.MRI phenotypes based on cerebral lesions and atrophy in patients with multiple sclerosis. J Neurol Sci. 2014 Nov 15;346(1-2):250-4. doi: 10.1016/j.jns.2014.08.047. Epub 2014 Sep 6.

115	Levy Barazany H, Barazany D, Puckett L, Blanga-Kanfi S, Borenstein-Auerbach N, Yang K, Peron JP, Weiner HL, Frenkel D.Brain MRI of nasal MOG therapeutic effect in relapsing-progressive EAE. Exp Neurol. 2014 May;255:63-70. doi: 10.1016/j.expneurol.2014.02.010. Epub 2014 Feb 16.

116	Tran HC, Gardner S, Weiner HL, Liebes LF, Finlay JL.Pilot study assessing a seven-day continuous intrathecal topotecan infusion for recurrent or progressive leptomeningeal metastatic cancer. J Oncol Pharm Pract. 2014 Jun;20(3):229-32. doi: 10.1177/1078155213494940. Epub 2013 Aug 8.

117	Malik MT, Healy BC, Benson LA, Kivisäkk P, Musallam A, Weiner HL, Chitnis T.Factors associated with recovery from acute optic neuritis in patients with multiple sclerosis. Neurology. 2014 Jun 17;82(24):2173-9. doi: 10.1212/WNL.0000000000000524. Epub 2014 May 21.

118	Kothare SV, Singh K, Chalifoux JR, Staley BA, Weiner HL, Menzer K, Devinsky O.Severity of manifestations in tuberous sclerosis complex in relation to genotype. Epilepsia. 2014 Jul;55(7):1025-9. doi: 10.1111/epi.12680. Epub 2014 Jun 10.

119	Kothare SV, Singh K, Hochman T, Chalifoux JR, Staley BA, Weiner HL, Menzer K, Devinsky O.Genotype/phenotype in tuberous sclerosis complex: associations with clinical and radiologic manifestations. Epilepsia. 2014 Jul;55(7):1020-4. doi: 10.1111/epi.12627. Epub 2014 Apr 22.

120

Kivisäkk P, Francois K, Mbianda J, Gandhi R, Weiner HL, Khoury SJ.Effect of natalizumab treatment on circulating plasmacytoid dendritic cells: a cross-sectional observational study in patients with multiple sclerosis. PLoS One. 2014 Jul 30;9(7):e103716. doi: 10.1371/journal.pone.0103716. eCollection 2014.

121

Yamasaki R, Lu H, Butovsky O, Ohno N, Rietsch AM, Cialic R, Wu PM, Doykan CE, Lin J, Cotleur AC, Kidd G, Zorlu MM, Sun N, Hu W, Liu L, Lee JC, Taylor SE, Uehlein L, Dixon D, Gu J, Floruta CM, Zhu M, Charo IF, Weiner HL, Ransohoff RM.Differential roles of microglia and monocytes in the inflamed central nervous system. J Exp Med. 2014 Jul 28;211(8):1533-49. doi: 10.1084/jem.20132477. Epub 2014 Jul 7.

122	Harter DH, Bassani L, Rodgers SD, Roth J, Devinsky O, Carlson C, Wisoff JH, Weiner HL.A management strategy for intraventricular subependymal giant cell astrocytomas in tuberous sclerosis complex. J Neurosurg Pediatr. 2014 Jan;13(1):21-8. doi: 10.3171/2013.9.PEDS13193. Epub 2013 Nov 1.

123

Sotnikov I, Veremeyko T, Starossom SC, Barteneva N, Weiner HL, Ponomarev ED.Correction: Platelets Recognize Brain-Specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation. PLoS One. 2014 Jan 8;9(1). doi: 10.1371/annotation/0bbea8d3-1f94-48af-915c-aec02da2f5c3. eCollection 2014.

124	Roth J, Carlson C, Devinsky O, Harter DH, Macallister WS, Weiner HL.Safety of staged epilepsy surgery in children. Neurosurgery. 2014 Feb;74(2):154-62. doi: 10.1227/NEU.0000000000000231.

125

Quintana FJ, Patel B, Yeste A, Nyirenda M, Kenison J, Rahbari R, Fetco D, Hussain M, O''Mahony J, Magalhaes S, McGowan M, Johnson T, Rajasekharan S, Narayanan S, Arnold DL, Weiner HL, Banwell B, Bar-Or A; Canadian Pediatric Demyelinating Disease Network.Epitope spreading as an early pathogenic event in pediatric multiple sclerosis. Neurology. 2014 Dec 9;83(24):2219-26. doi: 10.1212/WNL.0000000000001066. Epub 2014 Nov 7.

126	Ruppe V, Dilsiz P, Reiss CS, Carlson C, Devinsky O, Zagzag D, Weiner HL, Talos DM.Developmental brain abnormalities in tuberous sclerosis complex: a comparative tissue analysis of cortical tubers and perituberal cortex. Epilepsia. 2014 Apr;55(4):539-50. doi: 10.1111/epi.12545. Epub 2014 Feb 11.

127

Kivisäkk P, Healy BC, Francois K, Gandhi R, Gholipour T, Egorova S, Sevdalinova V, Quintana F, Chitnis T, Weiner HL, Khoury SJ.Evaluation of circulating osteopontin levels in an unselected cohort of patients with multiple sclerosis: relevance for biomarker development. Mult Scler. 2014 Apr;20(4):438-44. doi: 10.1177/1352458513503052. Epub 2013 Sep 4.

128

Bove R, Secor E, Healy BC, Musallam A, Vaughan T, Glanz BI, Greeke E, Weiner HL, Chitnis T, Wicks P, De Jager PL.Evaluation of an online platform for multiple sclerosis research: patient description, validation of severity scale, and exploration of BMI effects on disease course. PLoS One. 2013;8(3):e59707. doi: 10.1371/journal.pone.0059707. Epub 2013 Mar 20.

129	Hu D, Weiner HL, Ritz J.Identification of cytolytic CD161- CD56+ regulatory CD8 T cells in human peripheral blood. PLoS One. 2013;8(3):e59545. doi: 10.1371/journal.pone.0059545. Epub 2013 Mar 19.

130	Frenkel D, Wilkinson K, Zhao L, Hickman SE, Means TK, Puckett L, Farfara D, Kingery ND, Weiner HL, El Khoury J.Scara1 deficiency impairs clearance of soluble amyloid-? by mononuclear phagocytes and accelerates Alzheimer''s-like disease progression. Nat Commun. 2013;4:2030. doi: 10.1038/ncomms3030.

131	Shekhtman Y, Kim I, Riviello JJ Jr, Milla SS, Weiner HL.Focal resection of leptomeningeal angioma in a rare case of Sturge-Weber syndrome without facial nevus. Pediatr Neurosurg. 2013;49(2):99-104. doi: 10.1159/000357357. Epub 2014 Jan 9.

132

Ottoboni L, Frohlich IY, Lee M, Healy BC, Keenan BT, Xia Z, Chitnis T, Guttmann CR, Khoury SJ, Weiner HL, Hafler DA, De Jager PL.Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus. Neurology. 2013 Nov 26;81(22):1891-9. doi: 10.1212/01.wnl.0000436612.66328.8a. Epub 2013 Oct 30.

133

Xia Z, Secor E, Chibnik LB, Bove RM, Cheng S, Chitnis T, Cagan A, Gainer VS, Chen PJ, Liao KP, Shaw SY, Ananthakrishnan AN, Szolovits P, Weiner HL, Karlson EW, Murphy SN, Savova GK, Cai T, Churchill SE, Plenge RM, Kohane IS, De Jager PL.Modeling disease severity in multiple sclerosis using electronic health records. PLoS One. 2013 Nov 11;8(11):e78927. doi: 10.1371/journal.pone.0078927. eCollection 2013.

134	Messina S, Vargas-Lowy D, Musallam A, Healy BC, Kivisakk P, Gandhi R, Bove R, Gholipour T, Khoury S, Weiner HL, Chitnis T.Increased leptin and A-FABP levels in relapsing and progressive forms of MS. BMC Neurol. 2013 Nov 11;13:172. doi: 10.1186/1471-2377-13-172.

135

Chalifoux JR, Perry N, Katz JS, Wiggins GC, Roth J, Miles D, Devinsky O, Weiner HL, Milla SS.The ability of high field strength 7-T magnetic resonance imaging to reveal previously uncharacterized brain lesions in patients with tuberous sclerosis complex. J Neurosurg Pediatr. 2013 Mar;11(3):268-73. doi: 10.3171/2012.12.PEDS12338. Epub 2013 Jan 4.

136

Gandhi R, Healy B, Gholipour T, Egorova S, Musallam A, Hussain MS, Nejad P, Patel B, Hei H, Khoury S, Quintana F, Kivisakk P, Chitnis T, Weiner HL.Circulating microRNAs as biomarkers for disease staging in multiple sclerosis. Ann Neurol. 2013 Jun;73(6):729-40. doi: 10.1002/ana.23880. Epub 2013 Jul 8.

137	Koeglsperger T, Li S, Brenneis C, Saulnier JL, Mayo L, Carrier Y, Selkoe DJ, Weiner HL.Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-?1 in the CNS. Glia. 2013 Jun;61(6):985-1002. doi: 10.1002/glia.22490. Epub 2013 Mar 28.

138	Hersh DS, Chun J, Weiner HL, Pulitzer S, Rusinek H, Roth J, Devinsky O, Milla SS.Longitudinal quantitative analysis of the tuber-to-brain proportion in patients with tuberous sclerosis. J Neurosurg Pediatr. 2013 Jul;12(1):71-6. doi: 10.3171/2013.4.PEDS12468. Epub 2013 May 10.

139	Ponomarev ED, Veremeyko T, Weiner HL.MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS. Glia. 2013 Jan;61(1):91-103. doi: 10.1002/glia.22363. Epub 2012 May 31. Review.

140	Stankiewicz JM, Kolb H, Karni A, Weiner HL.Role of immunosuppressive therapy for the treatment of multiple sclerosis. Neurotherapeutics. 2013 Jan;10(1):77-88. doi: 10.1007/s13311-012-0172-3. Review.

141

Rezende RM, Oliveira RP, Medeiros SR, Gomes-Santos AC, Alves AC, Loli FG, Guimarães MA, Amaral SS, da Cunha AP, Weiner HL, Azevedo V, Miyoshi A, Faria AM.Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells. J Autoimmun. 2013 Feb;40:45-57. doi: 10.1016/j.jaut.2012.07.012. Epub 2012 Aug 28.

142

Roth J, Roach ES, Bartels U, Jóźwiak S, Koenig MK, Weiner HL, Franz DN, Wang HZ.Subependymal giant cell astrocytoma: diagnosis, screening, and treatment. Recommendations from the International Tuberous Sclerosis Complex Consensus Conference 2012. Pediatr Neurol. 2013 Dec;49(6):439-44. doi: 10.1016/j.pediatrneurol.2013.08.017. Epub 2013 Oct 15.

143	Beynon V, Quintana FJ, Weiner HL.Activated human CD4+CD45RO+ memory T-cells indirectly inhibit NLRP3 inflammasome activation through downregulation of P2X7R signalling. PLoS One. 2012;7(6):e39576. doi: 10.1371/journal.pone.0039576. Epub 2012 Jun 29.

144	da Cunha AP, Weiner HL.Induction of immunological tolerance by oral anti-CD3. Clin Dev Immunol. 2012;2012:425021. doi: 10.1155/2012/425021. Epub 2011 Nov 14. Review.

145	Mittal A, Murugaiyan G, Beynon V, Hu D, Weiner HL.IL-27 induction of IL-21 from human CD8+ T cells induces granzyme B in an autocrine manner. Immunol Cell Biol. 2012 Sep;90(8):831-5. doi: 10.1038/icb.2012.14. Epub 2012 Mar 20.

146

Ceccarelli A, Jackson JS, Tauhid S, Arora A, Gorky J, Dell''Oglio E, Bakshi A, Chitnis T, Khoury SJ, Weiner HL, Guttmann CR, Bakshi R, Neema M.The impact of lesion in-painting and registration methods on voxel-based morphometry in detecting regional cerebral gray matter atrophy in multiple sclerosis. AJNR Am J Neuroradiol. 2012 Sep;33(8):1579-85. doi: 10.3174/ajnr.A3083. Epub 2012 Mar 29.

147

Butovsky O, Siddiqui S, Gabriely G, Lanser AJ, Dake B, Murugaiyan G, Doykan CE, Wu PM, Gali RR, Iyer LK, Lawson R, Berry J, Krichevsky AM, Cudkowicz ME, Weiner HL.Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest. 2012 Sep;122(9):3063-87. doi: 10.1172/JCI62636. Epub 2012 Aug 6.

148	Ottoboni L, Keenan BT, Tamayo P, Kuchroo M, Mesirov JP, Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, De Jager PL.An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity. Sci Transl Med. 2012 Sep 26;4(153):153ra131.

149	Ma TS, Elliott RE, Ruppe V, Devinsky O, Kuzniecky R, Weiner HL, Carlson C.Electrocorticographic evidence of perituberal cortex epileptogenicity in tuberous sclerosis complex. J Neurosurg Pediatr. 2012 Nov;10(5):376-82. doi: 10.3171/2012.8.PEDS1285. Epub 2012 Sep 21.

150

Coles AJ, Twyman CL, Arnold DL, Cohen JA, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Miller T, Fisher E, Sandbrink R, Lake SL, Margolin DH, Oyuela P, Panzara MA, Compston DA; CARE-MS II investigators.Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Lancet. 2012 Nov 24;380(9856):1829-39. doi: 10.1016/S0140-6736(12)61768-1. Epub 2012 Nov 1.

151

Cohen JA, Coles AJ, Arnold DL, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Fisher E, Brinar VV, Giovannoni G, Stojanovic M, Ertik BI, Lake SL, Margolin DH, Panzara MA, Compston DA; CARE-MS I investigators.Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. Lancet. 2012 Nov 24;380(9856):1819-28. doi: 10.1016/S0140-6736(12)61769-3. Epub 2012 Nov 1.

152

Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS.The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity. 2012 Nov 16;37(5):930-46. doi: 10.1016/j.immuni.2012.07.016. Epub 2012 Nov 1.

153
Weiner HL.Role of T cells in neuromyelitis optica. Ann Neurol. 2012 Jul;72(1):6-8. doi: 10.1002/ana.23669.

154	Mayo L, Quintana FJ, Weiner HL.The innate immune system in demyelinating disease. Immunol Rev. 2012 Jul;248(1):170-87. doi: 10.1111/j.1600-065X.2012.01135.x. Review.

155	Veremeyko T, Starossom SC, Weiner HL, Ponomarev ED.Detection of microRNAs in microglia by real-time PCR in normal CNS and during neuroinflammation. J Vis Exp. 2012 Jul 23;(65). pii: 4097. doi: 10.3791/4097.

156	Quintana FJ, Yeste A, Weiner HL, Covacu R.Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis. J Neuroimmunol. 2012 Jul 15;248(1-2):53-7. doi: 10.1016/j.jneuroim.2012.01.002. Epub 2012 May 12. Review.

157	Yeste A, Nadeau M, Burns EJ, Weiner HL, Quintana FJ.Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11270-5. doi: 10.1073/pnas.1120611109. Epub 2012 Jun 27.

158	Glanz BI, Healy BC, Hviid LE, Chitnis T, Weiner HL.Cognitive deterioration in patients with early multiple sclerosis: a 5-year study. J Neurol Neurosurg Psychiatry. 2012 Jan;83(1):38-43. doi: 10.1136/jnnp.2010.237834. Epub 2011 Jul 11.

159	Hu D, Liu X, Zeng W, Weiner HL, Ritz J.A clonal model for human CD8+ regulatory T cells: unrestricted contact-dependent killing of activated CD4+ T cells. Eur J Immunol. 2012 Jan;42(1):69-79. doi: 10.1002/eji.201141618. Epub 2011 Nov 28.

160	Roth J, Olasunkanmi A, Ma TS, Carlson C, Devinsky O, Harter DH, Weiner HL.Epilepsy control following intracranial monitoring without resection in young children. Epilepsia. 2012 Feb;53(2):334-41. doi: 10.1111/j.1528-1167.2011.03380.x. Epub 2012 Jan 13.

161

Lifshitz V, Weiss R, Benromano T, Kfir E, Blumenfeld-Katzir T, Tempel-Brami C, Assaf Y, Xia W, Wyss-Coray T, Weiner HL, Frenkel D.Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model. Neurobiol Aging. 2012 Feb;33(2):432.e1-432.e13. doi: 10.1016/j.neurobiolaging.2011.01.006. Epub 2011 Mar 2.

162	Quintana FJ, Farez MF, Izquierdo G, Lucas M, Cohen IR, Weiner HL.Antigen microarrays identify CNS-produced autoantibodies in RRMS. Neurology. 2012 Feb 21;78(8):532-9. doi: 10.1212/WNL.0b013e318247f9f3. Epub 2012 Jan 18.

163

Glanz BI, Dégano IR, Rintell DJ, Chitnis T, Weiner HL, Healy BC.Work productivity in relapsing multiple sclerosis: associations with disability, depression, fatigue, anxiety, cognition, and health-related quality of life. Value Health. 2012 Dec;15(8):1029-35. doi: 10.1016/j.jval.2012.07.010. Epub 2012 Oct 25.

164	Murugaiyan G, Beynon V, Pires Da Cunha A, Joller N, Weiner HL.IFN-? limits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27. J Immunol. 2012 Dec 1;189(11):5277-83. doi: 10.4049/jimmunol.1200808. Epub 2012 Nov 2.

165	Rodgers SD, Bassani L, Weiner HL, Harter DH.Stereotactic endoscopic resection and surgical management of a subependymal giant cell astrocytoma: case report. J Neurosurg Pediatr. 2012 Apr;9(4):417-20. doi: 10.3171/2011.12.PEDS11349.

166	Katz JS, Milla SS, Wiggins GC, Devinsky O, Weiner HL, Roth J.Intraventricular lesions in tuberous sclerosis complex: a possible association with the caudate nucleus. J Neurosurg Pediatr. 2012 Apr;9(4):406-13. doi: 10.3171/2011.12.PEDS11418.

167

Holland CM, Charil A, Csapo I, Liptak Z, Ichise M, Khoury SJ, Bakshi R, Weiner HL, Guttmann CR.The relationship between normal cerebral perfusion patterns and white matter lesion distribution in 1,249 patients with multiple sclerosis. J Neuroimaging. 2012 Apr;22(2):129-36. doi: 10.1111/j.1552-6569.2011.00585.x. Epub 2011 Mar 29.

168

Moodie J, Healy BC, Buckle GJ, Gauthier SA, Glanz BI, Arora A, Ceccarelli A, Tauhid S, Han XM, Venkataraman A, Chitnis T, Khoury SJ, Guttmann CR, Weiner HL, Neema M, Bakshi R.Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study. J Neurol Sci. 2012 Apr 15;315(1-2):49-54. doi: 10.1016/j.jns.2011.11.040. Epub 2011 Dec 28.

169	Wu HY, Quintana FJ, da Cunha AP, Dake BT, Koeglsperger T, Starossom SC, Weiner HL.In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling. PLoS One. 2011;6(8):e23618. doi: 10.1371/journal.pone.0023618. Epub 2011 Aug 23.

170	Laroni A, Gandhi R, Beynon V, Weiner HL.IL-27 imparts immunoregulatory function to human NK cell subsets. PLoS One. 2011;6(10):e26173. doi: 10.1371/journal.pone.0026173. Epub 2011 Oct 19.

171	Murugaiyan G, Beynon V, Mittal A, Joller N, Weiner HL.Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2011 Sep 1;187(5):2213-21. doi: 10.4049/jimmunol.1003952. Epub 2011 Jul 25.

172

Liguori M, Meier DS, Hildenbrand P, Healy BC, Chitnis T, Baruch NF, Khoury SJ, Weiner HL, Bakshi R, Barkhof F, Guttmann CR.One year activity on subtraction MRI predicts subsequent 4 year activity and progression in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2011 Oct;82(10):1125-31. doi: 10.1136/jnnp.2011.242115. Epub 2011 Mar 22.

173	Santiago AF, Alves AC, Oliveira RP, Fernandes RM, Paula-Silva J, Assis FA, Carvalho CR, Weiner HL, Faria AM.Aging correlates with reduction in regulatory-type cytokines and T cells in the gut mucosa. Immunobiology. 2011 Oct;216(10):1085-93. doi: 10.1016/j.imbio.2011.05.007. Epub 2011 May 14.

174	Weiner HL, da Cunha AP, Quintana F, Wu H.Oral tolerance. Immunol Rev. 2011 May;241(1):241-59. doi: 10.1111/j.1600-065X.2011.01017.x. Review.

175	Haranhalli N, Anand D, Wisoff JH, Harter DH, Weiner HL, Blate M, Roth J.Intrathecal baclofen therapy: complication avoidance and management. Childs Nerv Syst. 2011 Mar;27(3):421-7. doi: 10.1007/s00381-010-1277-9. Epub 2010 Sep 18.

176	Roth J, Olasunkanmi A, MacAllister WS, Weil E, Uy CC, Devinsky O, Weiner HL.Quality of life following epilepsy surgery for children with tuberous sclerosis complex. Epilepsy Behav. 2011 Mar;20(3):561-5. doi: 10.1016/j.yebeh.2010.11.003. Epub 2011 Feb 1.

177	Pacione D, Blei F, Devinsky O, Weiner HL, Roth J.Coagulation abnormalities in children undergoing epilepsy surgery. J Neurosurg Pediatr. 2011 Jun;7(6):654-9. doi: 10.3171/2011.3.PEDS10559.

178	Sansa G, Carlson C, Doyle W, Weiner HL, Bluvstein J, Barr W, Devinsky O.Medically refractory epilepsy in autism. Epilepsia. 2011 Jun;52(6):1071-5. doi: 10.1111/j.1528-1167.2011.03069.x. Epub 2011 Apr 19.

179	Gholipour T, Healy B, Baruch NF, Weiner HL, Chitnis T.Demographic and clinical characteristics of malignant multiple sclerosis. Neurology. 2011 Jun 7;76(23):1996-2001. doi: 10.1212/WNL.0b013e31821e559d.

180	Hviid LE, Healy BC, Rintell DJ, Chitnis T, Weiner HL, Glanz BI.Patient reported outcomes in benign multiple sclerosis. Mult Scler. 2011 Jul;17(7):876-84. doi: 10.1177/1352458511398370. Epub 2011 Mar 3.

181	Roth J, Galeano E, Milla S, Hartmannsgruber MW, Weiner HL.Multiple epidural hematomas and hemodynamic collapse caused by a subgaleal drain and suction-induced intracranial hypotension: case report. Neurosurgery. 2011 Jan;68(1):E271-5; discussion E276. doi: 10.1227/NEU.0b013e3181fe6165.

182	Ponomarev ED, Veremeyko T, Barteneva N, Krichevsky AM, Weiner HL.MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-?-PU.1 pathway. Nat Med. 2011 Jan;17(1):64-70. doi: 10.1038/nm.2266. Epub 2010 Dec 5.

183

Cassani B, Villablanca EJ, Quintana FJ, Love PE, Lacy-Hulbert A, Blaner WS, Sparwasser T, Snapper SB, Weiner HL, Mora JR.Gut-tropic T cells that express integrin ?4?7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology. 2011 Dec;141(6):2109-18. doi: 10.1053/j.gastro.2011.09.015. Epub 2011 Sep 16.

184

Kappos L, Bates D, Edan G, Eraksoy M, Garcia-Merino A, Grigoriadis N, Hartung HP, Havrdová E, Hillert J, Hohlfeld R, Kremenchutzky M, Lyon-Caen O, Miller A, Pozzilli C, Ravnborg M, Saida T, Sindic C, Vass K, Clifford DB, Hauser S, Major EO, O''Connor PW, Weiner HL, Clanet M, Gold R, Hirsch HH, Radüe EW, Sørensen PS, King J.Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring. Lancet Neurol. 2011 Aug;10(8):745-58. doi: 10.1016/S1474-4422(11)70149-1. Review.

185	Carlson C, Teutonico F, Elliott RE, Moshel YA, LaJoie J, Miles D, Devinsky O, Weiner HL.Bilateral invasive electroencephalography in patients with tuberous sclerosis complex: a path to surgery? J Neurosurg Pediatr. 2011 Apr;7(4):421-30. doi: 10.3171/2011.1.PEDS10348.

186

Gross R, Healy BC, Cepok S, Chitnis T, Khoury SJ, Hemmer B, Weiner HL, Hafler DA, De Jager PL.Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments. J Neuroimmunol. 2011 Apr;233(1-2):168-74. doi: 10.1016/j.jneuroim.2010.10.038. Epub 2010 Nov 27.

187

Stankiewicz JM, Glanz BI, Healy BC, Arora A, Neema M, Benedict RH, Guss ZD, Tauhid S, Buckle GJ, Houtchens MK, Khoury SJ, Weiner HL, Guttmann CR, Bakshi R.Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis. J Neuroimaging. 2011 Apr;21(2):e50-6. doi: 10.1111/j.1552-6569.2009.00449.x.

188	Liguori M, Healy BC, Glanz BI, Khoury SJ, Moscufo N, Weiner HL, De Jager PL, Guttmann CR.HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal study. Genes Immun. 2011 Apr;12(3):183-90. doi: 10.1038/gene.2010.58. Epub 2010 Dec 23.

189	Oida T, Weiner HL.Murine CD4 T cells produce a new form of TGF-? as measured by a newly developed TGF-? bioassay. PLoS One. 2011 Apr 11;6(4):e18365. doi: 10.1371/journal.pone.0018365.

190

Khoury SJ, Healy BC, Kivisäkk P, Viglietta V, Egorova S, Guttmann CR, Wedgwood JF, Hafler DA, Weiner HL, Buckle G, Cook S, Reddy S.A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis. Arch Neurol. 2010 Sep;67(9):1055-61. doi: 10.1001/archneurol.2010.222.

191

Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, Burns EJ, Sherr DH, Weiner HL, Kuchroo VK.The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol. 2010 Sep;11(9):854-61. doi: 10.1038/ni.1912. Epub 2010 Aug 1.

192	Gandhi R, Kumar D, Burns EJ, Nadeau M, Dake B, Laroni A, Kozoriz D, Weiner HL, Quintana FJ.Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol. 2010 Sep;11(9):846-53. doi: 10.1038/ni.1915. Epub 2010 Aug 1.

193	Oida T, Weiner HL.Overexpression of TGF-� 1 gene induces cell surface localized glucose-regulated protein 78-associated latency-associated peptide/TGF-�. J Immunol. 2010 Sep 15;185(6):3529-35. doi: 10.4049/jimmunol.0904121. Epub 2010 Aug 18.

194

Wu HY, Maron R, Tukpah AM, Weiner HL.Mucosal anti-CD3 monoclonal antibody attenuates collagen-induced arthritis that is associated with induction of LAP+ regulatory T cells and is enhanced by administration of an emulsome-based Th2-skewing adjuvant. J Immunol. 2010 Sep 15;185(6):3401-7. doi: 10.4049/jimmunol.1000836. Epub 2010 Aug 18.

195	Peron JP, Yang K, Chen ML, Brandao WN, Basso AS, Commodaro AG, Weiner HL, Rizzo LV.Oral tolerance reduces Th17 cells as well as the overall inflammation in the central nervous system of EAE mice. J Neuroimmunol. 2010 Oct 8;227(1-2):10-7. doi: 10.1016/j.jneuroim.2010.06.002. Epub 2010 Jul 2.

196	Oida T, Weiner HL.Depletion of TGF-? from fetal bovine serum. J Immunol Methods. 2010 Oct 31;362(1-2):195-8. doi: 10.1016/j.jim.2010.09.008. Epub 2010 Sep 15.

197	Xia Z, Chibnik LB, Glanz BI, Liguori M, Shulman JM, Tran D, Khoury SJ, Chitnis T, Holyoak T, Weiner HL, Guttmann CR, De Jager PL.A putative Alzheimer''s disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. PLoS One. 2010 Nov 30;5(11):e14169. doi: 10.1371/journal.pone.0014169.

198

Quintana FJ, Murugaiyan G, Farez MF, Mitsdoerffer M, Tukpah AM, Burns EJ, Weiner HL.An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20768-73. doi: 10.1073/pnas.1009201107. Epub 2010 Nov 10.

199	Oida T, Weiner HL.TGF-? induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction. PLoS One. 2010 Nov 24;5(11):e15523. doi: 10.1371/journal.pone.0015523.

200	Ilan Y, Maron R, Tukpah AM, Maioli TU, Murugaiyan G, Yang K, Wu HY, Weiner HL.Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9765-70. doi: 10.1073/pnas.0908771107. Epub 2010 May 5.

201	Gandhi R, Farez MF, Wang Y, Kozoriz D, Quintana FJ, Weiner HL.Cutting edge: human latency-associated peptide+ T cells: a novel regulatory T cell subset. J Immunol. 2010 May 1;184(9):4620-4. doi: 10.4049/jimmunol.0903329. Epub 2010 Apr 5.

202

Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK.T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8706-11. doi: 10.1073/pnas.0910359107. Epub 2010 Apr 5.

203	Quintana FJ, Iglesias AH, Farez MF, Caccamo M, Burns EJ, Kassam N, Oukka M, Weiner HL.Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish. PLoS One. 2010 Mar 5;5(3):e9478. doi: 10.1371/journal.pone.0009478.

204	Glanz BI, Healy BC, Rintell DJ, Jaffin SK, Bakshi R, Weiner HL.The association between cognitive impairment and quality of life in patients with early multiple sclerosis. J Neurol Sci. 2010 Mar 15;290(1-2):75-9. doi: 10.1016/j.jns.2009.11.004. Epub 2009 Nov 26.

205

Cree BA, Rioux JD, McCauley JL, Gourraud PA, Goyette P, McElroy J, De Jager P, Santaniello A, Vyse TJ, Gregersen PK, Mirel D, Hafler DA, Haines JL, Pericak-Vance MA, Compston A, Sawcer SJ, Oksenberg JR, Hauser SL; IMAGEN; IMSGC.A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. PLoS One. 2010 Jun 25;5(6):e11296. doi: 10.1371/journal.pone.0011296.

206	Murugaiyan G, Mittal A, Weiner HL.Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11495-500. doi: 10.1073/pnas.1002099107. Epub 2010 Jun 7.

207	Moshel YA, Elliott R, Teutonico F, Sellin J, Carlson C, Devinsky O, Weiner HL.Do tubers contain function? Resection of epileptogenic foci in perirolandic cortex in children with tuberous sclerosis complex. Epilepsia. 2010 Jul;51(7):1242-51. doi: 10.1111/j.1528-1167.2009.02493.x. Epub 2010 May 17.

208

Ilan Y, Zigmond E, Lalazar G, Dembinsky A, Ben Ya''acov A, Hemed N, Kasis I, Axelrod E, Zolotarov L, Klein A, El Haj M, Gandhi R, Baecher-Allan C, Wu H, Murugaiyan G, Kivisakk P, Farez MF, Quintana FJ, Khoury SJ, Weiner HL.Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cells. J Clin Immunol. 2010 Jan;30(1):167-77. doi: 10.1007/s10875-009-9323-7. Epub 2009 Sep 16.

209	Elkhalifa A, Weiner H.Cyclophosphamide Treatment of MS: Current Therapeutic Approaches and Treatment Regimens. Int MS J. 2010 Jan;17(1):12-8.

210	Balashov KE, Aung LL, Vaknin-Dembinsky A, Dhib-Jalbut S, Weiner HL.Interferon-? inhibits toll-like receptor 9 processing in multiple sclerosis. Ann Neurol. 2010 Dec;68(6):899-906. doi: 10.1002/ana.22136.

211	Vega JL, Saban D, Carrier Y, Masli S, Weiner HL.Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-?. Ocul Immunol Inflamm. 2010 Dec;18(6):459-69. doi: 10.3109/09273948.2010.509532. Epub 2010 Oct 1.

212	Souweidane MM, Krieger MD, Weiner HL, Finlay JL.Surgical management of primary central nervous system germ cell tumors: proceedings from the Second International Symposium on Central Nervous System Germ Cell Tumors. J Neurosurg Pediatr. 2010 Aug;6(2):125-30. doi: 10.3171/2010.5.PEDS09112. Review.

213	Meier DS, Balashov KE, Healy B, Weiner HL, Guttmann CR.Seasonal prevalence of MS disease activity. Neurology. 2010 Aug 31;75(9):799-806. doi: 10.1212/WNL.0b013e3181f0734c.

214

Healy BC, Liguori M, Tran D, Chitnis T, Glanz B, Wolfish C, Gauthier S, Buckle G, Houtchens M, Stazzone L, Khoury S, Hartzmann R, Fernandez-Vina M, Hafler DA, Weiner HL, Guttmann CR, De Jager PL.HLA B*44: protective effects in MS susceptibility and MRI outcome measures. Neurology. 2010 Aug 17;75(7):634-40. doi: 10.1212/WNL.0b013e3181ed9c9c.

215	Gandhi R, Laroni A, Weiner HL.Role of the innate immune system in the pathogenesis of multiple sclerosis. J Neuroimmunol. 2010 Apr 15;221(1-2):7-14. doi: 10.1016/j.jneuroim.2009.10.015. Review.

216	Bollo RJ, Carlson C, Schevon C, Wisoff JH, Devinsky O, Weiner HL.Extraoperative functional mapping and staged resection of supratentorial tumors near eloquent cortex in children. Pediatr Neurosurg. 2009;45(3):175-80. doi: 10.1159/000218199. Epub 2009 May 14.

217	Zota V, Nemirovsky A, Baron R, Fisher Y, Selkoe DJ, Altmann DM, Weiner HL, Monsonego A.HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. J Immunol. 2009 Sep 1;183(5):3522-30. doi: 10.4049/jimmunol.0900620. Epub 2009 Aug 12.

218

Gauthier SA, Glanz BI, Mandel M, Tsagkaropoulos A, Neema M, Stankiewicz J, Arora A, Duan Y, Liptak Z, Egorova S, Buckle GJ, Bakshi R, Guttmann CR, Khoury SJ, Weiner HL.Incidence and factors associated with treatment failure in the CLIMB multiple sclerosis cohort study. J Neurol Sci. 2009 Sep 15;284(1-2):116-9. doi: 10.1016/j.jns.2009.04.020. Epub 2009 May 9.

219

Sampat MP, Berger AM, Healy BC, Hildenbrand P, Vass J, Meier DS, Chitnis T, Weiner HL, Bakshi R, Guttmann CR.Regional white matter atrophy--based classification of multiple sclerosis in cross-sectional and longitudinal data. AJNR Am J Neuroradiol. 2009 Oct;30(9):1731-9. doi: 10.3174/ajnr.A1659. Epub 2009 Aug 20.

220	Elliott RE, Carlson C, Kalhorn SP, Moshel YA, Weiner HL, Devinsky O, Doyle WK.Refractory epilepsy in tuberous sclerosis: vagus nerve stimulation with or without subsequent resective surgery. Epilepsy Behav. 2009 Nov;16(3):454-60. doi: 10.1016/j.yebeh.2009.08.018. Epub 2009 Sep 19.

221	Weiner HL.The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease? Ann Neurol. 2009 Mar;65(3):239-48. doi: 10.1002/ana.21640. Review.

222	Quintana FJ, Weiner HL.Environmental control of Th17 differentiation. Eur J Immunol. 2009 Mar;39(3):655-7. doi: 10.1002/eji.200839198.

223

Yang K, Vega JL, Hadzipasic M, Schatzmann Peron JP, Zhu B, Carrier Y, Masli S, Rizzo LV, Weiner HL.Deficiency of thrombospondin-1 reduces Th17 differentiation and attenuates experimental autoimmune encephalomyelitis. J Autoimmun. 2009 Mar;32(2):94-103. doi: 10.1016/j.jaut.2008.12.004. Epub 2009 Feb 1.

224

De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA.The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5264-9. doi: 10.1073/pnas.0813310106. Epub 2009 Feb 23.

225	Wu HY, Center EM, Tsokos GC, Weiner HL.Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells. Lupus. 2009 Jun;18(7):586-96. doi: 10.1177/0961203308100511.

226	Kivisäkk P, Healy BC, Viglietta V, Quintana FJ, Hootstein MA, Weiner HL, Khoury SJ.Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells. Neurology. 2009 Jun 2;72(22):1922-30. doi: 10.1212/WNL.0b013e3181a8266f.

227

De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S; International MS Genetics Consortium, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR.Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet. 2009 Jul;41(7):776-82. doi: 10.1038/ng.401. Epub 2009 Jun 14.

228	Bollo RJ, Berliner JL, Fischer I, Miles DK, Thiele EA, Zagzag D, Weiner HL.Extraventricular subependymal giant cell tumor in a child with tuberous sclerosis complex. J Neurosurg Pediatr. 2009 Jul;4(1):85-90. doi: 10.3171/2009.3.PEDS08225.

229

Frenkel D, Pachori AS, Zhang L, Dembinsky-Vaknin A, Farfara D, Petrovic-Stojkovic S, Dzau VJ, Weiner HL.Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injury. Int Immunol. 2009 Jul;21(7):817-29. doi: 10.1093/intimm/dxp051. Epub 2009 Jun 10.

230

Neema M, Goldberg-Zimring D, Guss ZD, Healy BC, Guttmann CR, Houtchens MK, Weiner HL, Horsfield MA, Hackney DB, Alsop DC, Bakshi R.3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis. Neuroimage. 2009 Jul 1;46(3):633-41. doi: 10.1016/j.neuroimage.2009.03.001. Epub 2009 Mar 10.

231

Neema M, Arora A, Healy BC, Guss ZD, Brass SD, Duan Y, Buckle GJ, Glanz BI, Stazzone L, Khoury SJ, Weiner HL, Guttmann CR, Bakshi R.Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis. J Neuroimaging. 2009 Jan;19(1):3-8. doi: 10.1111/j.1552-6569.2008.00296.x.

232	Gauthier SA, Berger AM, Liptak Z, Duan Y, Egorova S, Buckle GJ, Glanz BI, Khoury SJ, Bakshi R, Weiner HL, Guttmann CR.Rate of brain atrophy in benign vs early multiple sclerosis. Arch Neurol. 2009 Feb;66(2):234-7. doi: 10.1001/archneurol.2008.567.

233	Ali EN, Healy BC, Stazzone LA, Brown BA, Weiner HL, Khoury SJ.Daclizumab in treatment of multiple sclerosis patients. Mult Scler. 2009 Feb;15(2):272-4. doi: 10.1177/1352458508097468. Epub 2009 Jan 9.

234	Chen ML, Yan BS, Kozoriz D, Weiner HL.Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms. Eur J Immunol. 2009 Dec;39(12):3423-35. doi: 10.1002/eji.200939441.

235	Murugaiyan G, Mittal A, Lopez-Diego R, Maier LM, Anderson DE, Weiner HL.IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J Immunol. 2009 Aug 15;183(4):2435-43. doi: 10.4049/jimmunol.0900568. Epub 2009 Jul 22.

236	Sosunov AA, Wu X, Weiner HL, Mikell CB, Goodman RR, Crino PD, McKhann GM 2nd.Tuberous sclerosis: a primary pathology of astrocytes? Epilepsia. 2008;49 Suppl 2:53-62. doi: 10.1111/j.1528-1167.2008.01493.x.

237

Liptak Z, Berger AM, Sampat MP, Charil A, Felsovalyi O, Healy BC, Hildenbrand P, Khoury SJ, Weiner HL, Bakshi R, Guttmann CR.Medulla oblongata volume: a biomarker of spinal cord damage and disability in multiple sclerosis. AJNR Am J Neuroradiol. 2008 Sep;29(8):1465-70. doi: 10.3174/ajnr.A1162. Epub 2008 Jun 12.

238	Bollo RJ, Kalhorn SP, Carlson C, Haegeli V, Devinsky O, Weiner HL.Epilepsy surgery and tuberous sclerosis complex: special considerations. Neurosurg Focus. 2008 Sep;25(3):E13. doi: 10.3171/FOC/2008/25/9/E13. Review.

239	Viglietta V, Bourcier K, Buckle GJ, Healy B, Weiner HL, Hafler DA, Egorova S, Guttmann CR, Rusche JR, Khoury SJ.CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial. Neurology. 2008 Sep 16;71(12):917-24. doi: 10.1212/01.wnl.0000325915.00112.61.

240	Lopez-Diego RS, Weiner HL.Novel therapeutic strategies for multiple sclerosis--a multifaceted adversary. Nat Rev Drug Discov. 2008 Nov;7(11):909-25. doi: 10.1038/nrd2358. Review.

241

Bakshi R, Neema M, Healy BC, Liptak Z, Betensky RA, Buckle GJ, Gauthier SA, Stankiewicz J, Meier D, Egorova S, Arora A, Guss ZD, Glanz B, Khoury SJ, Guttmann CR, Weiner HL.Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale. Arch Neurol. 2008 Nov;65(11):1449-53. doi: 10.1001/archneur.65.11.1449.

242	Wu HY, Quintana FJ, Weiner HL.Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells. J Immunol. 2008 Nov 1;181(9):6038-50.

243

Ochi H, Abraham M, Ishikawa H, Frenkel D, Yang K, Basso A, Wu H, Chen ML, Gandhi R, Miller A, Maron R, Weiner HL.New immunosuppressive approaches: oral administration of CD3-specific antibody to treat autoimmunity. J Neurol Sci. 2008 Nov 15;274(1-2):9-12. doi: 10.1016/j.jns.2008.07.027. Epub 2008 Sep 18. Review.

244	Frenkel D, Puckett L, Petrovic S, Xia W, Chen G, Vega J, Dembinsky-Vaknin A, Shen J, Plante M, Burt DS, Weiner HL.A nasal proteosome adjuvant activates microglia and prevents amyloid deposition. Ann Neurol. 2008 May;63(5):591-601. doi: 10.1002/ana.21340.

245	Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL.Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature. 2008 May 1;453(7191):65-71. doi: 10.1038/nature06880. Epub 2008 Mar 23.

246	Weiner HL.A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis. J Neurol. 2008 Mar;255 Suppl 1:3-11. doi: 10.1007/s00415-008-1002-8. Review.

247	Vaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL, Weiner HL.Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. J Neuroimmunol. 2008 Mar;195(1-2):140-5. doi: 10.1016/j.jneuroim.2008.01.002. Epub 2008 Apr 10.

248	Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL.Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J Immunol. 2008 Jun 1;180(11):7327-37.

249

De Jager PL, Rossin E, Pyne S, Tamayo P, Ottoboni L, Viglietta V, Weiner M, Soler D, Izmailova E, Faron-Yowe L, O''Brien C, Freeman S, Granados S, Parker A, Roubenoff R, Mesirov JP, Khoury SJ, Hafler DA, Weiner HL.Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. Brain. 2008 Jul;131(Pt 7):1701-11. doi: 10.1093/brain/awn118. Epub 2008 Jun 21.

250

Fischer I, Cunliffe C, Bollo RJ, Weiner HL, Devinsky O, Ruiz-Tachiquin ME, Venuto T, Pearlman A, Chiriboga L, Schneider RJ, Ostrer H, Miller DC.Glioma-like proliferation within tissues excised as tubers in patients with tuberous sclerosis complex. Acta Neuropathol. 2008 Jul;116(1):67-77. doi: 10.1007/s00401-008-0391-1. Epub 2008 Jun 26.

251	Bauman JA, Feoli E, Romanelli P, Doyle WK, Devinsky O, Weiner HL.Multistage epilepsy surgery: safety, efficacy, and utility of a novel approach in pediatric extratemporal epilepsy. Neurosurgery. 2008 Feb;62 Suppl 2:489-505. doi: 10.1227/01.neu.0000316252.47028.2d.

252	Sayegh MH, Weiner HL.Regulating rejection with cell therapy. Nat Biotechnol. 2008 Feb;26(2):191-2. doi: 10.1038/nbt0208-191.

253	Abraham M, Karni A, Dembinsky A, Miller A, Gandhi R, Anderson D, Weiner HL.In vitro induction of regulatory T cells by anti-CD3 antibody in humans. J Autoimmun. 2008 Feb-Mar;30(1-2):21-8. doi: 10.1016/j.jaut.2007.11.007.

254	Teutonico F, Mai R, Devinsky O, Lo Russo G, Weiner HL, Borrelli P, Balottin U, Veggiotti P.Epilepsy surgery in tuberous sclerosis complex: early predictive elements and outcome. Childs Nerv Syst. 2008 Dec;24(12):1437-45. doi: 10.1007/s00381-008-0679-4. Epub 2008 Aug 14.

255

Quintana FJ, Farez MF, Viglietta V, Iglesias AH, Merbl Y, Izquierdo G, Lucas M, Basso AS, Khoury SJ, Lucchinetti CF, Cohen IR, Weiner HL.Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18889-94. doi: 10.1073/pnas.0806310105. Epub 2008 Nov 21.

256	Murugaiyan G, Mittal A, Weiner HL.Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis. J Immunol. 2008 Dec 1;181(11):7480-8.

257	Weiner HL.Oral laquinimod for treatment of relapsing-remitting multiple sclerosis. Lancet Neurol. 2008 Aug;7(8):672-3. doi: 10.1016/S1474-4422(08)70148-0.

258	Quintana FJ, Farez MF, Weiner HL.Systems biology approaches for the study of multiple sclerosis. J Cell Mol Med. 2008 Aug;12(4):1087-93. doi: 10.1111/j.1582-4934.2008.00375.x. Epub 2008 May 26. Review.

259	Basso AS, Frenkel D, Quintana FJ, Costa-Pinto FA, Petrovic-Stojkovic S, Puckett L, Monsonego A, Bar-Shir A, Engel Y, Gozin M, Weiner HL.Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis. J Clin Invest. 2008 Apr;118(4):1532-43. doi: 10.1172/JCI33464.

260	Glanz BI, Holland CM, Gauthier SA, Amunwa EL, Liptak Z, Houtchens MK, Sperling RA, Khoury SJ, Guttmann CR, Weiner HL.Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis. Mult Scler. 2007 Sep;13(8):1004-10. Epub 2007 Jul 10.

261	Meier DS, Weiner HL, Guttmann CR.MR imaging intensity modeling of damage and repair in multiple sclerosis: relationship of short-term lesion recovery to progression and disability. AJNR Am J Neuroradiol. 2007 Nov-Dec;28(10):1956-63.

262

Kappos L, Bates D, Hartung HP, Havrdova E, Miller D, Polman CH, Ravnborg M, Hauser SL, Rudick RA, Weiner HL, O''Connor PW, King J, Radue EW, Yousry T, Major EO, Clifford DB.Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring. Lancet Neurol. 2007 May;6(5):431-41. Review.

263	Gauthier SA, Mandel M, Guttmann CR, Glanz BI, Khoury SJ, Betensky RA, Weiner HL.Predicting short-term disability in multiple sclerosis. Neurology. 2007 Jun 12;68(24):2059-65.

264	Meier DS, Weiner HL, Guttmann CR.Time-series modeling of multiple sclerosis disease activity: a promising window on disease progression and repair potential? Neurotherapeutics. 2007 Jul;4(3):485-98. Review.

265	Carrier Y, Yuan J, Kuchroo VK, Weiner HL.Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice. J Immunol. 2007 Jan 1;178(1):179-85.

266	Carrier Y, Yuan J, Kuchroo VK, Weiner HL.Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity. J Immunol. 2007 Jan 1;178(1):172-8.

267	Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL.A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol. 2007 Dec;8(12):1380-9. Epub 2007 Nov 11.

268	Mandel M, Gauthier SA, Guttmann CR, Weiner HL, Betensky RA.Estimating Time to Event From Longitudinal Categorical Data: An Analysis of Multiple Sclerosis Progression. J Am Stat Assoc. 2007 Dec;102(480):1254-1266.

269	Bluestone JA, Thomson AW, Shevach EM, Weiner HL.What does the future hold for cell-based tolerogenic therapy? Nat Rev Immunol. 2007 Aug;7(8):650-4. doi: 10.1038/nri2137. Review.

270	Post NH, Wisoff JH, Thorne CH, Weiner HL.Transient syringomyelia leading to acute neurological deterioration after repair of a lipomyelomeningocele: case report. Neurosurgery. 2007 Aug;61(2):E426; discussion E426.

271	Ishikawa H, Ochi H, Chen ML, Frenkel D, Maron R, Weiner HL.Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody. Diabetes. 2007 Aug;56(8):2103-9. Epub 2007 Apr 24.

272	Madhavan D, Schaffer S, Yankovsky A, Arzimanoglou A, Renaldo F, Zaroff CM, LaJoie J, Weiner HL, Andermann E, Franz DN, Leonard J, Connolly M, Cascino GD, Devinsky O.Surgical outcome in tuberous sclerosis complex: a multicenter survey. Epilepsia. 2007 Aug;48(8):1625-8. Epub 2007 May 1.

273	Madhavan D, Weiner HL, Carlson C, Devinsky O, Kuzniecky R.Local epileptogenic networks in tuberous sclerosis complex: a case review. Epilepsy Behav. 2007 Aug;11(1):140-6. Epub 2007 Jul 5.

274	Vaknin-Dembinsky A, Weiner HL.Relationship of immunologic abnormalities and disease stage in multiple sclerosis: implications for therapy. J Neurol Sci. 2007 Aug 15;259(1-2):90-4. Epub 2007 May 23. Review.

275	Gandhi R, Anderson DE, Weiner HL.Cutting Edge: Immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-beta-dependent manner. J Immunol. 2007 Apr 1;178(7):4017-21.

276	Faria AM, Weiner HL.Oral tolerance and TGF-beta-producing cells. Inflamm Allergy Drug Targets. 2006 Sep;5(3):179-90. Review.

277	Karni A, Abraham M, Monsonego A, Cai G, Freeman GJ, Hafler D, Khoury SJ, Weiner HL.Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response. J Immunol. 2006 Sep 15;177(6):4196-202.

278	Gauthier SA, Glanz BI, Mandel M, Weiner HL.A model for the comprehensive investigation of a chronic autoimmune disease: the multiple sclerosis CLIMB study. Autoimmun Rev. 2006 Oct;5(8):532-6. Epub 2006 Mar 22. Review.

279	Rawle FE, Pratt KP, Labelle A, Weiner HL, Hough C, Lillicrap D.Induction of partial immune tolerance to factor VIII through prior mucosal exposure to the factor VIII C2 domain. J Thromb Haemost. 2006 Oct;4(10):2172-9. Epub 2006 Jul 5.

280	Hauser SL, Weiner HL.Natalizumab: immune effects and implications for therapy. Ann Neurol. 2006 May;59(5):731-2.

281	Quintana FJ, Weiner HL.Understanding natural and pathological autoimmunity. J Neuroimmunol. 2006 May;174(1-2):1-2. Epub 2006 Mar 13.

282	Weiner HL, Carlson C, Ridgway EB, Zaroff CM, Miles D, LaJoie J, Devinsky O.Epilepsy surgery in young children with tuberous sclerosis: results of a novel approach. Pediatrics. 2006 May;117(5):1494-502.

283	Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK.Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006 May 11;441(7090):235-8. Epub 2006 Apr 30.

284	Gonnella PA, Chen YH, Waldner H, Weiner HL.Induction of oral tolerization in CD86 deficient mice: a role for CD86 and B cells in the up-regulation of TGF-beta. J Autoimmun. 2006 Mar;26(2):73-81.

285	Wu HY, Monsonego A, Weiner HL.The mechanism of nasal tolerance in lupus prone mice is T-cell anergy induced by immature B cells that lack B7 expression. J Autoimmun. 2006 Mar;26(2):116-26. Epub 2006 Jan 19.

286

Monsonego A, Imitola J, Petrovic S, Zota V, Nemirovsky A, Baron R, Fisher Y, Owens T, Weiner HL.Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer''s disease. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5048-53. Epub 2006 Mar 20.

287	Ochi H, Abraham M, Ishikawa H, Frenkel D, Yang K, Basso AS, Wu H, Chen ML, Gandhi R, Miller A, Maron R, Weiner HL.Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells. Nat Med. 2006 Jun;12(6):627-35. Epub 2006 May 21.

288	Faria AM, Weiner HL.Oral tolerance: therapeutic implications for autoimmune diseases. Clin Dev Immunol. 2006 Jun-Dec;13(2-4):143-57. Review.

289	Piedimonte LR, Wailes IK, Weiner HL.Tuberous sclerosis complex: molecular pathogenesis and animal models. Neurosurg Focus. 2006 Jan 15;20(1):E4. Review.

290

Laplaud DA, Berthelot L, Miqueu P, Bourcier K, Moynard J, Oudinet Y, Guillet M, Ruiz C, Oden N, Brouard S, Guttmann CR, Weiner HL, Khoury SJ, Soulillou JP.Serial blood T cell repertoire alterations in multiple sclerosis patients; correlation with clinical and MRI parameters. J Neuroimmunol. 2006 Aug;177(1-2):151-60. Epub 2006 Jun 27.

291	Oida T, Xu L, Weiner HL, Kitani A, Strober W.TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling. J Immunol. 2006 Aug 15;177(4):2331-9.

292	Zhang X, Reddy J, Ochi H, Frenkel D, Kuchroo VK, Weiner HL.Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells. Int Immunol. 2006 Apr;18(4):495-503. Epub 2006 Mar 15.

293	Frenkel D, Maron R, Burt DS, Weiner HL.Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease. J Clin Invest. 2005 Sep;115(9):2423-33. Epub 2005 Aug 11.

294	Piedimonte LR, Wailes IK, Weiner HL.Medulloblastoma: mouse models and novel targeted therapies based on the Sonic hedgehog pathway. Neurosurg Focus. 2005 Nov 15;19(5):E8. Review.

295	Prat A, Biernacki K, Saroli T, Orav JE, Guttmann CR, Weiner HL, Khoury SJ, Antel JP.Kinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability. Arch Neurol. 2005 May;62(5):795-800.

296	Abraham M, Shapiro S, Karni A, Weiner HL, Miller A.Gelatinases (MMP-2 and MMP-9) are preferentially expressed by Th1 vs. Th2 cells. J Neuroimmunol. 2005 Jun;163(1-2):157-64. Epub 2005 Apr 2.

297	Douglas AF, Weiner HL, Schwartz DR.Prolonged intrathecal baclofen withdrawal syndrome. Case report and discussion of current therapeutic management. J Neurosurg. 2005 Jun;102(6):1133-6. Review.

298	Bauman JA, Feoli E, Romanelli P, Doyle WK, Devinsky O, Weiner HL.Multistage epilepsy surgery: safety, efficacy, and utility of a novel approach in pediatric extratemporal epilepsy. Neurosurgery. 2005 Feb;56(2):318-34.

299	Gauthier SA, Buckle GJ, Weiner HL.Immunosuppressive therapy for multiple sclerosis. Neurol Clin. 2005 Feb;23(1):247-72, viii-ix. Review.

300	Zaroff CM, Morrison C, Ferraris N, Weiner HL, Miles DK, Devinsky O.Developmental outcome of epilepsy surgery in tuberous sclerosis complex. Epileptic Disord. 2005 Dec;7(4):321-6.

301	Miyamoto K, Kingsley CI, Zhang X, Jabs C, Izikson L, Sobel RA, Weiner HL, Kuchroo VK, Sharpe AH.The ICOS molecule plays a crucial role in the development of mucosal tolerance. J Immunol. 2005 Dec 1;175(11):7341-7.

304	Weiner HL.Tuberous sclerosis and multiple tubers: localizing the epileptogenic zone. Epilepsia. 2004;45 Suppl 4:41-2.

305	Weiner HL, Ferraris N, LaJoie J, Miles D, Devinsky O.Epilepsy surgery for children with tuberous sclerosis complex. J Child Neurol. 2004 Sep;19(9):687-9. Review.

306	Weiner HL.Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease. Arch Neurol. 2004 Oct;61(10):1613-5. Review.

307	Hara H, Monsonego A, Yuasa K, Adachi K, Xiao X, Takeda S, Takahashi K, Weiner HL, Tabira T.Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer''s disease. J Alzheimers Dis. 2004 Oct;6(5):483-8.

308	Gonnella PA, Waldner HP, Kodali D, Weiner HL.Induction of low dose oral tolerance in IL-10 deficient mice with experimental autoimmune encephalomyelitis. J Autoimmun. 2004 Nov;23(3):193-200.

309	Meier DS, Weiner HL, Khoury SJ, Guttmann CR.Magnetic resonance imaging surrogates of multiple sclerosis pathology and their relationship to central nervous system atrophy. J Neuroimaging. 2004 Jul;14(3 Suppl):46S-53S. Review.

310

Karni A, Balashov K, Hancock WW, Bharanidharan P, Abraham M, Khoury SJ, Weiner HL.Cyclophosphamide modulates CD4+ T cells into a T helper type 2 phenotype and reverses increased IFN-gamma production of CD8+ T cells in secondary progressive multiple sclerosis. J Neuroimmunol. 2004 Jan;146(1-2):189-98.

311	Klein RS, Izikson L, Means T, Gibson HD, Lin E, Sobel RA, Weiner HL, Luster AD.IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis. J Immunol. 2004 Jan 1;172(1):550-9.

312	Zhang X, Koldzic DN, Izikson L, Reddy J, Nazareno RF, Sakaguchi S, Kuchroo VK, Weiner HL.IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. Int Immunol. 2004 Feb;16(2):249-56.

313	Weiner HL.Current issues in the treatment of human diseases by mucosal tolerance. Ann N Y Acad Sci. 2004 Dec;1029:211-24. Review.

314	Cai G, Karni A, Oliveira EM, Weiner HL, Hafler DA, Freeman GJ.PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. Cell Immunol. 2004 Aug;230(2):89-98.

315	Hommes OR, Weiner HL.Clinical practice of immunosuppressive treatments in multiple sclerosis: results of a second international questionnaire. J Neurol Sci. 2004 Aug 15;223(1):65-7.

318	Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA.Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med. 2004 Apr 5;199(7):971-9.

319
Wu HY, Weiner HL.Oral tolerance. Immunol Res. 2003;28(3):265-84. Review.

320	Monsonego A, Beserman ZP, Kipnis J, Yoles E, Weiner HL, Schwartz M.Beneficial effect of orally administered myelin basic protein in EAE-susceptible Lewis rats in a model of acute CNS degeneration. J Autoimmun. 2003 Sep;21(2):131-8.

321	Monsonego A, Weiner HL.Immunotherapeutic approaches to Alzheimer''s disease. Science. 2003 Oct 31;302(5646):834-8. Review.

322	Lee A, Maldonado M, Baybis M, Walsh CA, Scheithauer B, Yeung R, Parent J, Weiner HL, Crino PB.Markers of cellular proliferation are expressed in cortical tubers. Ann Neurol. 2003 May;53(5):668-73.

323	Kuo DJ, Weiner HL, Wisoff J, Miller DC, Knopp EA, Finlay JL.Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol. 2003 May;25(5):372-8.

324	Hopfer H, Maron R, Butzmann U, Helmchen U, Weiner HL, Kalluri R.The importance of cell-mediated immunity in the course and severity of autoimmune anti-glomerular basement membrane disease in mice. FASEB J. 2003 May;17(8):860-8.

325	Bettelli E, Pagany M, Weiner HL, Linington C, Sobel RA, Kuchroo VK.Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med. 2003 May 5;197(9):1073-81.

326	Faria AM, Maron R, Ficker SM, Slavin AJ, Spahn T, Weiner HL.Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis. J Autoimmun. 2003 Mar;20(2):135-45.

327	Oida T, Zhang X, Goto M, Hachimura S, Totsuka M, Kaminogawa S, Weiner HL.CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism. J Immunol. 2003 Mar 1;170(5):2516-22.

328	Gonnella PA, Kodali D, Weiner HL.Induction of low dose oral tolerance in monocyte chemoattractant protein-1- and CCR2-deficient mice. J Immunol. 2003 Mar 1;170(5):2316-22.

329	Cotton F, Weiner HL, Jolesz FA, Guttmann CR.MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals. Neurology. 2003 Feb 25;60(4):640-6.

330	Frenkel D, Huang Z, Maron R, Koldzic DN, Hancock WW, Moskowitz MA, Weiner HL.Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells. J Immunol. 2003 Dec 15;171(12):6549-55.

331	Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL.Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest. 2003 Aug;112(3):415-22.

332	Makhlouf K, Weiner HL, Khoury SJ.Potential of beta2-adrenoceptor agonists as add-on therapy for multiple sclerosis: focus on salbutamol (albuterol). CNS Drugs. 2002;16(1):1-8. Review.

333	Romanelli P, Najjar S, Weiner HL, Devinsky O.Epilepsy surgery in tuberous sclerosis: multistage procedures with bilateral or multilobar foci. J Child Neurol. 2002 Sep;17(9):689-92.

334	Maron R, Sukhova G, Faria AM, Hoffmann E, Mach F, Libby P, Weiner HL.Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation. 2002 Sep 24;106(13):1708-15.

335	Soos JM, Stüve O, Youssef S, Bravo M, Johnson HM, Weiner HL, Zamvil SS.Cutting edge: oral type I IFN-tau promotes a Th2 bias and enhances suppression of autoimmune encephalomyelitis by oral glatiramer acetate. J Immunol. 2002 Sep 1;169(5):2231-5.

336	Weiner HL, Bakst R, Hurlbert MS, Ruggiero J, Ahn E, Lee WS, Stephen D, Zagzag D, Joyner AL, Turnbull DH.Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1. Cancer Res. 2002 Nov 15;62(22):6385-9.

337	Comabella M, Imitola J, Weiner HL, Khoury SJ.Interferon-beta treatment alters peripheral blood monocytes chemokine production in MS patients. J Neuroimmunol. 2002 May;126(1-2):205-12.

338	McCarthy JG, Bradley JP, Stelnicki EJ, Stokes T, Weiner HL.Hung span method of scaphocephaly reconstruction in patients with elevated intracranial pressure. Plast Reconstr Surg. 2002 May;109(6):2009-18.

339	Izikson L, Klein RS, Luster AD, Weiner HL.Targeting monocyte recruitment in CNS autoimmune disease. Clin Immunol. 2002 May;103(2):125-31. Review.

340	Wei X, Warfield SK, Zou KH, Wu Y, Li X, Guimond A, Mugler JP 3rd, Benson RR, Wolfson L, Weiner HL, Guttmann CR.Quantitative analysis of MRI signal abnormalities of brain white matter with high reproducibility and accuracy. J Magn Reson Imaging. 2002 Feb;15(2):203-9.

341	Maron R, Slavin AJ, Hoffmann E, Komagata Y, Weiner HL.Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines. Int Immunol. 2002 Feb;14(2):131-8.

342

Spahn TW, Herbst H, Rennert PD, Lügering N, Maaser C, Kraft M, Fontana A, Weiner HL, Domschke W, Kucharzik T.Induction of colitis in mice deficient of Peyer''s patches and mesenteric lymph nodes is associated with increased disease severity and formation of colonic lymphoid patches. Am J Pathol. 2002 Dec;161(6):2273-82.

343	Weiner HL, Selkoe DJ.Inflammation and therapeutic vaccination in CNS diseases. Nature. 2002 Dec 19-26;420(6917):879-84. Review.

344	Weiner HL, Cohen JA.Treatment of multiple sclerosis with cyclophosphamide: critical review of clinical and immunologic effects. Mult Scler. 2002 Apr;8(2):142-54. Review.

345	Hommes OR, Weiner HL.Results of an international questionnaire on immunosuppressive treatment of multiple sclerosis. Mult Scler. 2002 Apr;8(2):139-41.

346	Weiner HL, Lichtenbaum RA, Wisoff JH, Snow RB, Souweidane MM, Bruce JN, Finlay JL.Delayed surgical resection of central nervous system germ cell tumors. Neurosurgery. 2002 Apr;50(4):727-33; discussion 733-4.

347	Spahn TW, Weiner HL, Rennert PD, Lügering N, Fontana A, Domschke W, Kucharzik T.Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer''s patches. Eur J Immunol. 2002 Apr;32(4):1109-13.

348	Karni A, Koldzic DN, Bharanidharan P, Khoury SJ, Weiner HL.IL-18 is linked to raised IFN-gamma in multiple sclerosis and is induced by activated CD4(+) T cells via CD40-CD40 ligand interactions. J Neuroimmunol. 2002 Apr;125(1-2):134-40.

349	Kopell BH, Sala D, Doyle WK, Feldman DS, Wisoff JH, Weiner HL.Subfascial implantation of intrathecal baclofen pumps in children: technical note. Neurosurgery. 2001 Sep;49(3):753-6; discussion 756-7.

350	Romanelli P, Weiner HL, Najjar S, Devinsky O.Bilateral resective epilepsy surgery in a child with tuberous sclerosis: case report. Neurosurgery. 2001 Sep;49(3):732-4; discussion 735.

351	Weiner HL.Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect. 2001 Sep;3(11):947-54. Review.

352	Makhlouf K, Weiner HL, Khoury SJ.Increased percentage of IL-12+ monocytes in the blood correlates with the presence of active MRI lesions in MS. J Neuroimmunol. 2001 Sep 3;119(1):145-9.

353	Slavin AJ, Soos JM, Stuve O, Patarroyo JC, Weiner HL, Fontana A, Bikoff EK, Zamvil SS.Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity. J Clin Invest. 2001 Oct;108(8):1133-9.

354	Zhang X, Izikson L, Liu L, Weiner HL.Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol. 2001 Oct 15;167(8):4245-53.

355	Lemere CA, Maron R, Selkoe DJ, Weiner HL.Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer''s disease. DNA Cell Biol. 2001 Nov;20(11):705-11.

356	Levine JP, Stelnicki E, Weiner HL, Bradley JP, McCarthy JG.Hyponatremia in the postoperative craniofacial pediatric patient population: a connection to cerebral salt wasting syndrome and management of the disorder. Plast Reconstr Surg. 2001 Nov;108(6):1501-8.

357
Weiner HL.The fine line between autoimmune and allergic encephalomyelitis. Nat Immunol. 2001 Mar;2(3):193-4.

358	Encinas JA, Lees MB, Sobel RA, Symonowicz C, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK.Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis. Int Immunol. 2001 Mar;13(3):257-64.

359	Slavin AJ, Maron R, Weiner HL.Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes. Int Immunol. 2001 Jun;13(6):825-33.

360

Sands SA, Kellie SJ, Davidow AL, Diez B, Villablanca J, Weiner HL, Pietanza MC, Balmaceda C, Finlay JL.Long-term quality of life and neuropsychologic functioning for patients with CNS germ-cell tumors: from the First International CNS Germ-Cell Tumor Study. Neuro Oncol. 2001 Jul;3(3):174-83. doi: 10.1093/neuonc/3.3.174.

361	Makhlouf K, Comabella M, Imitola J, Weiner HL, Khoury SJ.Oral salbutamol decreases IL-12 in patients with secondary progressive multiple sclerosis. J Neuroimmunol. 2001 Jul 2;117(1-2):156-65.

362	Sperling RA, Guttmann CR, Hohol MJ, Warfield SK, Jakab M, Parente M, Diamond EL, Daffner KR, Olek MJ, Orav EJ, Kikinis R, Jolesz FA, Weiner HL.Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study. Arch Neurol. 2001 Jan;58(1):115-21.

363	Chu ML, Sala DA, Weiner HL.Intrathecal baclofen in X-linked adrenoleukodystrophy. Pediatr Neurol. 2001 Feb;24(2):156-8.

364	Maron R, Guerau-de-Arellano M, Zhang X, Weiner HL.Oral administration of insulin to neonates suppresses spontaneous and cyclophosphamide induced diabetes in the NOD mouse. J Autoimmun. 2001 Feb;16(1):21-8.

365	Benardete EA, Leonard MA, Weiner HL.Comparison of frameless stereotactic systems: accuracy, precision, and applications. Neurosurgery. 2001 Dec;49(6):1409-15; discussion 1415-6.

366	Weiner HL.The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells. Nat Immunol. 2001 Aug;2(8):671-2.

367	Weiner HL.Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev. 2001 Aug;182:207-14.

368	Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL.Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer''s disease. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10273-8. Epub 2001 Aug 21.

369	Spahn TW, Fontana A, Faria AM, Slavin AJ, Eugster HP, Zhang X, Koni PA, Ruddle NH, Flavell RA, Rennert PD, Weiner HL.Induction of oral tolerance to cellular immune responses in the absence of Peyer''s patches. Eur J Immunol. 2001 Apr;31(4):1278-87.

370	Gonnella PA, Waldner HP, Weiner HL.B cell-deficient (mu MT) mice have alterations in the cytokine microenvironment of the gut-associated lymphoid tissue (GALT) and a defect in the low dose mechanism of oral tolerance. J Immunol. 2001 Apr 1;166(7):4456-64.

371	Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Desai R, Hancock WW, Weiner HL, Selkoe DJ.Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice. Ann N Y Acad Sci. 2000;920:328-31.

372
Komagata Y, Weiner HL.Oral tolerance. Rev Immunogenet. 2000;2(1):61-73. Review.

373	Weiner HL, Zagzag D.Growth factor receptor tyrosine kinases: cell adhesion kinase family suggests a novel signaling mechanism in cancer. Cancer Invest. 2000;18(6):544-54. Review.

374	Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ.Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer''s disease. Ann Neurol. 2000 Oct;48(4):567-79.

375	Weiner HL.Oral tolerance, an active immunologic process mediated by multiple mechanisms. J Clin Invest. 2000 Oct;106(8):935-7.

376	Izikson L, Klein RS, Charo IF, Weiner HL, Luster AD.Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J Exp Med. 2000 Oct 2;192(7):1075-80.

377	Houten JK, Weiner HL.Pediatric intramedullary spinal cord tumors: special considerations. J Neurooncol. 2000 May;47(3):225-30. Review.

378	Weiner HL, Guttmann CR, Khoury SJ, Orav EJ, Hohol MJ, Kikinis R, Jolesz FA.Serial magnetic resonance imaging in multiple sclerosis: correlation with attacks, disability, and disease stage. J Neuroimmunol. 2000 May 1;104(2):164-73.

379	Balashov KE, Comabella M, Ohashi T, Khoury SJ, Weiner HL.Defective regulation of IFNgamma and IL-12 by endogenous IL-10 in progressive MS. Neurology. 2000 Jul 25;55(2):192-8.

380	Weiner HL, Huang H, Zagzag D, Boyce H, Lichtenbaum R, Ziff EB.Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors. Neurosurgery. 2000 Dec;47(6):1400-9.

381	Khoury SJ, Guttmann CR, Orav EJ, Kikinis R, Jolesz FA, Weiner HL.Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis. Arch Neurol. 2000 Aug;57(8):1183-9.

382	Rottman JB, Slavin AJ, Silva R, Weiner HL, Gerard CG, Hancock WW.Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. Eur J Immunol. 2000 Aug;30(8):2372-7.

383	Faria AM, Weiner HL.Oral tolerance: mechanisms and therapeutic applications. Adv Immunol. 1999;73:153-264. Review.

384	Garcia G, Weiner HL.Manipulation of Th responses by oral tolerance. Curr Top Microbiol Immunol. 1999;238:123-45. Review.

385	Weinberg JS, LeRoux PD, Panasci D, Weiner HL.Adult growing skull fracture mimicking a skull tumor. Acta Neurochir (Wien). 1999;141(5):545-6. Review.

386	Maron R, Hancock WW, Slavin A, Hattori M, Kuchroo V, Weiner HL.Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines. Int Immunol. 1999 Sep;11(9):1573-80.

387	Khoury SJ, Orav EJ, Guttmann CR, Kikinis R, Jolesz FA, Weiner HL.Changes in serum levels of ICAM and TNF-R correlate with disease activity in multiple sclerosis. Neurology. 1999 Sep 11;53(4):758-64.

388	Hohol MJ, Orav EJ, Weiner HL.Disease steps in multiple sclerosis: a longitudinal study comparing disease steps and EDSS to evaluate disease progression. Mult Scler. 1999 Oct;5(5):349-54.

389	Diez B, Balmaceda C, Matsutani M, Weiner HL.Germ cell tumors of the CNS in children: recent advances in therapy. Childs Nerv Syst. 1999 Oct;15(10):578-85. Review.

390	Weiner HL, Finlay JL.Surgery in the management of primary intracranial germ cell tumors. Childs Nerv Syst. 1999 Nov;15(11-12):770-3.

391	Garcia G, Komagata Y, Slavin AJ, Maron R, Weiner HL.Suppression of collagen-induced arthritis by oral or nasal administration of type II collagen. J Autoimmun. 1999 Nov;13(3):315-24.

392	Bradley JP, Hollier LH Jr, Weiner HL, McCarthy JG.Cranial vault deformity and intracranial hypertension secondary to cephalic molding at delivery: a case and its management. J Craniofac Surg. 1999 May;10(3):226-9.

393	Weiner HL.Oral tolerance with copolymer 1 for the treatment of multiple sclerosis. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3333-5. Review.

394

Kappos L, Moeri D, Radue EW, Schoetzau A, Schweikert K, Barkhof F, Miller D, Guttmann CR, Weiner HL, Gasperini C, Filippi M.Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis. Gadolinium MRI Meta-analysis Group. Lancet. 1999 Mar 20;353(9157):964-9.

395	Grapin-Botton A, Cambronero F, Weiner HL, Bonnin MA, Puelles L, Le Douarin NM.Patterning signals acting in the spinal cord override the organizing activity of the isthmus. Mech Dev. 1999 Jun;84(1-2):41-53.

396	Maron R, Melican NS, Weiner HL.Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally- and nasally-treated NOD mice suppress diabetes. J Autoimmun. 1999 Jun;12(4):251-8.

397	Balashov KE, Rottman JB, Weiner HL, Hancock WW.CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6873-8.

398
Weiner HL, van Rees EP.Mucosal tolerance. Immunol Lett. 1999 Jun 15;69(1):3-4.

399	Encinas JA, Wicker LS, Peterson LB, Mukasa A, Teuscher C, Sobel R, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK.QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2. Nat Genet. 1999 Feb;21(2):158-60.

400	Hohol MJ, Olek MJ, Orav EJ, Stazzone L, Hafler DA, Khoury SJ, Dawson DM, Weiner HL.Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: response to therapy is linked to the duration of progressive disease. Mult Scler. 1999 Dec;5(6):403-9.

401	Karussis D, Weiner HL, Abramsky O.Multiple sclerosis vs Lyme disease: a case presentation to a discussant and a review of the literature. Mult Scler. 1999 Dec;5(6):395-402. Review.

402	Spahn TW, Issazadah S, Salvin AJ, Weiner HL.Decreased severity of myelin oligodendrocyte glycoprotein peptide 33 - 35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR delta chain gene. Eur J Immunol. 1999 Dec;29(12):4060-71.

403	Weiner HL.Induction of oral tolerance to the acetylcholine receptor for treatment of myasthenia gravis. J Clin Invest. 1999 Dec;104(12):1667-8.

404	Schwarting A, Tesch G, Kinoshita K, Maron R, Weiner HL, Kelley VR.IL-12 drives IFN-gamma-dependent autoimmune kidney disease in MRL-Fas(lpr) mice. J Immunol. 1999 Dec 15;163(12):6884-91.

405	Liu L, Kuchroo VK, Weiner HL.B7.2 (CD86) but not B7.1 (CD80) costimulation is required for the induction of low dose oral tolerance. J Immunol. 1999 Aug 15;163(4):2284-90.

406	Kikinis R, Guttmann CR, Metcalf D, Wells WM 3rd, Ettinger GJ, Weiner HL, Jolesz FA.Quantitative follow-up of patients with multiple sclerosis using MRI: technical aspects. J Magn Reson Imaging. 1999 Apr;9(4):519-30.

407	Guttmann CR, Kikinis R, Anderson MC, Jakab M, Warfield SK, Killiany RJ, Weiner HL, Jolesz FA.Quantitative follow-up of patients with multiple sclerosis using MRI: reproducibility. J Magn Reson Imaging. 1999 Apr;9(4):509-18.

408	Liu LM, Weiner HL.T-cell response to orally administered antigens and its role in the treatment of autoimmune diseases. Chem Immunol. 1998;71:139-60. Review.

409	Weiner HL, Komagata Y.Oral tolerance and the treatment of rheumatoid arthritis. Springer Semin Immunopathol. 1998;20(1-2):289-308. Review.

410	Inobe J, Slavin AJ, Komagata Y, Chen Y, Liu L, Weiner HL.IL-4 is a differentiation factor for transforming growth factor-beta secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis. Eur J Immunol. 1998 Sep;28(9):2780-90.

411	Zamvil SS, Soos JM, Weiner HL.Pathogenesis and treatment of central nervous system demyelinating disease. Rev Neurol (Paris). 1998 Sep;154(8-9):573-5. Review.

412	Bettelli E, Das MP, Howard ED, Weiner HL, Sobel RA, Kuchroo VK.IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol. 1998 Oct 1;161(7):3299-306.

413	Balashov KE, Olek MJ, Smith DR, Khoury SJ, Weiner HL.Seasonal variation of interferon-gamma production in progressive multiple sclerosis. Ann Neurol. 1998 Nov;44(5):824-8.

414	Kuchroo VK, Weiner HL.Antigen-driven regulation of experimental autoimmune encephalomyelitis. Res Immunol. 1998 Nov-Dec;149(9):759-71; discussion 842-3, 855-60. Review.

415	Windhagen A, Anderson DE, Carrizosa A, Balashov K, Weiner HL, Hafler DA.Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis. J Neuroimmunol. 1998 Nov 2;91(1-2):1-9.

416	Weiner HL.A 21 point unifying hypothesis on the etiology and treatment of multiple sclerosis. Can J Neurol Sci. 1998 May;25(2):93-101. Review.

417	Gonnella PA, Chen Y, Inobe J, Komagata Y, Quartulli M, Weiner HL.In situ immune response in gut-associated lymphoid tissue (GALT) following oral antigen in TCR-transgenic mice. J Immunol. 1998 May 15;160(10):4708-18.

418	Khoury SJ, Weiner HL.Multiple sclerosis: what have we learned from magnetic resonance imaging studies? Arch Intern Med. 1998 Mar 23;158(6):565-73. Review.

419	Chen Y, Hancock WW, Marks R, Gonnella P, Weiner HL.Mechanisms of recovery from experimental autoimmune encephalomyelitis: T cell deletion and immune deviation in myelin basic protein T cell receptor transgenic mice. J Neuroimmunol. 1998 Mar 1;82(2):149-59.

420	Takashima H, Smith DR, Fukaura H, Khoury SJ, Hafler DA, Weiner HL.Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients. Clin Immunol Immunopathol. 1998 Jul;88(1):28-34.

421	Chen W, Jin W, Cook M, Weiner HL, Wahl SM.Oral delivery of group A streptococcal cell walls augments circulating TGF-beta and suppresses streptococcal cell wall arthritis. J Immunol. 1998 Dec 1;161(11):6297-304.

422	Liu L, Rich BE, Inobe J, Chen W, Weiner HL.Induction of Th2 cell differentiation in the primary immune response: dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4+ T cells to secrete IL-4. Int Immunol. 1998 Aug;10(8):1017-26.

423	Comabella M, Balashov K, Issazadeh S, Smith D, Weiner HL, Khoury SJ.Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy. J Clin Invest. 1998 Aug 15;102(4):671-8.

424	Maron R, Palanivel V, Weiner HL, Harn DA.Oral administration of schistosome egg antigens and insulin B-chain generates and enhances Th2-type responses in NOD mice. Clin Immunol Immunopathol. 1998 Apr;87(1):85-92.

425	Samoilova EB, Horton JL, Zhang H, Khoury SJ, Weiner HL, Chen Y.CTLA-4 is required for the induction of high dose oral tolerance. Int Immunol. 1998 Apr;10(4):491-8.

426
Weiner HL.Oral tolerance for the treatment of autoimmune diseases. Annu Rev Med. 1997;48:341-51. Review.

427	Fowler E, Weiner HL.Oral tolerance: elucidation of mechanisms and application to treatment of autoimmune diseases. Biopolymers. 1997;43(4):323-35. Review.

428	Liu L, Rich BE, Inobe J, Chen W, Weiner HL.A potential pathway of Th2 development during primary immune response. IL-10 pretreated dendritic cells can prime naive CD4+ T cells to secrete IL-4. Adv Exp Med Biol. 1997;417:375-81.

429	Smith DR, Balashov KE, Hafler DA, Khoury SJ, Weiner HL.Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia. Ann Neurol. 1997 Sep;42(3):313-8.

430	Weiner HL, Gonnella PA, Slavin A, Maron R.Oral tolerance: cytokine milieu in the gut and modulation of tolerance by cytokines. Res Immunol. 1997 Oct-Dec;148(8-9):528-33. Review.

431	Nussenblatt RB, Gery I, Weiner HL, Ferris FL, Shiloach J, Remaley N, Perry C, Caspi RR, Hafler DA, Foster CS, Whitcup SM.Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial. Am J Ophthalmol. 1997 May;123(5):583-92.

432	Chen Y, Inobe J, Weiner HL.Inductive events in oral tolerance in the TCR transgenic adoptive transfer model. Cell Immunol. 1997 May 25;178(1):62-8.

433	Weiner HL, Freed D, Woo HH, Rezai AR, Kim R, Epstein FJ.Intra-axial tumors of the cervicomedullary junction: surgical results and long-term outcome. Pediatr Neurosurg. 1997 Jul;27(1):12-8.

434	Weiner HL.Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol Today. 1997 Jul;18(7):335-43. Review.

435	Balashov KE, Smith DR, Khoury SJ, Hafler DA, Weiner HL.Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):599-603.

436	Hafler DA, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Fukaura H.Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis. Ann N Y Acad Sci. 1997 Dec 19;835:120-31.

437	Smith DR, Weiner HL.Immunologic aspects of neurologic and neuromuscular diseases. JAMA. 1997 Dec 10;278(22):1956-61. Review.

438	Hohol MJ, Guttmann CR, Orav J, Mackin GA, Kikinis R, Khoury SJ, Jolesz FA, Weiner HL.Serial neuropsychological assessment and magnetic resonance imaging analysis in multiple sclerosis. Arch Neurol. 1997 Aug;54(8):1018-25.

439	Polanski M, Melican NS, Zhang J, Weiner HL.Oral administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytokines. J Autoimmun. 1997 Aug;10(4):339-46.

440	Kent SC, Fukaura H, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA.Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients. Ann N Y Acad Sci. 1997 Apr 5;815:412-22.

441	Windhagen A, Nicholson LB, Weiner HL, Kuchroo VK, Hafler DA.Role of Th1 and Th2 cells in neurologic disorders. Chem Immunol. 1996;63:171-86. Review.

442	Encinas JA, Lees MB, Sobel RA, Symonowicz C, Greer JM, Shovlin CL, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK.Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. J Immunol. 1996 Sep 1;157(5):2186-92.

443	Encinas JA, Weiner HL, Kuchroo VK.Inheritance of susceptibility to experimental autoimmune encephalomyelitis. J Neurosci Res. 1996 Sep 15;45(6):655-69. Review.

444	Woo HH, Rezai AR, Knopp EA, Weiner HL, Miller DC, Kelly PJ.Contrast-enhancing progressive multifocal leukoencephalopathy: radiological and pathological correlations: case report. Neurosurgery. 1996 Nov;39(5):1031-4; discussion 1034-5.

445	Melamed D, Fishman-Lovell J, Uni Z, Weiner HL, Friedman A.Peripheral tolerance of Th2 lymphocytes induced by continuous feeding of ovalbumin. Int Immunol. 1996 May;8(5):717-24.

446	Olek MJ, Hohol MJ, Weiner HL.Methotrexate in the treatment of multiple sclerosis. Ann Neurol. 1996 May;39(5):684.

447

Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA.Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest. 1996 Jul 1;98(1):70-7.

448

al-Sabbagh A, Nelson PA, Akselband Y, Sobel RA, Weiner HL.Antigen-driven peripheral immune tolerance: suppression of experimental autoimmmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen. Cell Immunol. 1996 Jul 10;171(1):111-9.

449	Chen Y, Inobe J, Kuchroo VK, Baron JL, Janeway CA Jr, Weiner HL.Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):388-91.

450	Weiner HL, Mayer LF.Oral tolerance: mechanisms and applications. Introduction. Ann N Y Acad Sci. 1996 Feb 13;778:xiii-xviii.

451	Matsui M, Hafler DA, Weiner HL.Pilot study of oral tolerance to keyhole limpet hemocyanin in humans: down-regulation of KLH-reactive precursor-cell frequency. Ann N Y Acad Sci. 1996 Feb 13;778:398-404.

452	Inobe JI, Chen Y, Weiner HL.In vivo administration of IL-4 induces TGF-beta-producing cells and protects animals from experimental autoimmune encephalomyelitis. Ann N Y Acad Sci. 1996 Feb 13;778:390-2.

453	Akselband Y, Hoffer TL, Nelson PA, Gonnella PA, Weiner HL.Local and systemic immune responses in SJL/J mice during prolonged oral myelin basic protein administration. Ann N Y Acad Sci. 1996 Feb 13;778:358-61.

454	Maron R, Blogg NS, Polanski M, Hancock W, Weiner HL.Oral tolerance to insulin and the insulin B-chain: cell lines and cytokine patterns. Ann N Y Acad Sci. 1996 Feb 13;778:346-57.

455	Sayegh MH, Khoury SJ, Hancock WW, Weiner HL, Carpenter CB.Mechanisms of oral tolerance by MHC peptides. Ann N Y Acad Sci. 1996 Feb 13;778:338-45. Review.

456	Nussenblatt RB, Whitcup SM, de Smet MD, Caspi RR, Kozhich AT, Weiner HL, Vistica B, Gery I.Intraocular inflammatory disease (uveitis) and the use of oral tolerance: a status report. Ann N Y Acad Sci. 1996 Feb 13;778:325-37. Review.

457	Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA.Antigen-specific TGF-beta1 secretion with bovine myelin oral tolerization in multiple sclerosis. Ann N Y Acad Sci. 1996 Feb 13;778:251-7.

458	Hohol MJ, Khoury SJ, Cook SL, Orav EJ, Hafler DA, Weiner HL.Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial. Ann N Y Acad Sci. 1996 Feb 13;778:243-50.

459	Nelson PA, Akselband Y, Dearborn SM, Al-Sabbagh A, Tian ZJ, Gonnella PA, Zamvil SS, Chen Y, Weiner HL.Effect of oral beta interferon on subsequent immune responsiveness. Ann N Y Acad Sci. 1996 Feb 13;778:145-55.

460	Chen YH, Weiner HL.Dose-dependent activation and deletion of antigen-specific T cells following oral tolerance. Ann N Y Acad Sci. 1996 Feb 13;778:111-21. Review.

461	Weiner HL, Kelly PJ.A novel computer-assisted volumetric stereotactic approach for resecting tumors of the posterior parahippocampal gyrus. J Neurosurg. 1996 Aug;85(2):272-7.

462	Weiner HL, Rothman M, Miller DC, Ziff EB.Pediatric brain tumors express multiple receptor tyrosine kinases including novel cell adhesion kinases. Pediatr Neurosurg. 1996 Aug;25(2):64-71; discussion 71-2.

463

al-Sabbagh AM, Goad EP, Weiner HL, Nelson PA.Decreased CNS inflammation and absence of clinical exacerbation of disease after six months oral administration of bovine myelin in diseased SJL/J mice with chronic relapsing experimental autoimmune encephalomyelitis. J Neurosci Res. 1996 Aug 15;45(4):424-9.

464	Hafler DA, Weiner HL.Antigen-specific immunosuppression: oral tolerance for the treatment of autoimmune disease. Chem Immunol. 1995;60:126-49. Review.

465	Hafler DA, Weiner HL.Antigen specific therapies for the treatment of autoimmune diseases. Agents Actions Suppl. 1995;47:59-77. Review.

466	Weiner HL, Miller A, Khoury SJ, Zhang ZJ, al-Sabbagh A, Brod SA, Lider O, Higgins P, Sobel R, Matsui M, et al.Treatment of autoimmune diseases by oral tolerance to autoantigens. Adv Exp Med Biol. 1995;371B:1217-23. Review.

467	Lee M, Leahu D, Weiner HL, Abbott R, Wisoff JH, Epstein FJ.Complications of fourth-ventricular shunts. Pediatr Neurosurg. 1995;22(6):309-13; discussion 314.

468	Hafler DA, Weiner HL.Antigen-specific therapies for the treatment of autoimmune diseases. Springer Semin Immunopathol. 1995;17(1):61-76. Review.

469
Weiner HL.Oral tolerance: mobilizing the gut. Hosp Pract (1995). 1995 Sep 15;30(9):53-8. Review.

470	Weiner HL, Constantini S, Cohen H, Wisoff JH.Current treatment of normal-pressure hydrocephalus: comparison of flow-regulated and differential-pressure shunt valves. Neurosurgery. 1995 Nov;37(5):877-84.

471	Hancock WW, Polanski M, Zhang J, Blogg N, Weiner HL.Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E. Am J Pathol. 1995 Nov;147(5):1193-9.

472	Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH.B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell. 1995 Mar 10;80(5):707-18.

473	Balashov KE, Khoury SJ, Hafler DA, Weiner HL.Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. J Clin Invest. 1995 Jun;95(6):2711-9.

474	Chen Y, Inobe J, Weiner HL.Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression. J Immunol. 1995 Jul 15;155(2):910-6.

475	Prabhu Das MR, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, Kuchroo VK.Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation. Eur J Immunol. 1995 Jan;25(1):207-11.

476	Hohol MJ, Orav EJ, Weiner HL.Disease steps in multiple sclerosis: a simple approach to evaluate disease progression. Neurology. 1995 Feb;45(2):251-5.

477	Yoshino S, Quattrocchi E, Weiner HL.Suppression of antigen-induced arthritis in Lewis rats by oral administration of type II collagen. Arthritis Rheum. 1995 Aug;38(8):1092-6.

478	Weiner HL.The role of growth factor receptors in central nervous system development and neoplasia. Neurosurgery. 1995 Aug;37(2):179-93; discussion 193-4. Review.

479

Khoury SJ, Gallon L, Chen W, Betres K, Russell ME, Hancock WW, Carpenter CB, Sayegh MH, Weiner HL.Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo. J Exp Med. 1995 Aug 1;182(2):357-66.

480	Hafler DA, Weiner HL.Immunologic mechanisms and therapy in multiple sclerosis. Immunol Rev. 1995 Apr;144:75-107. Review.

481	Zamvil SS, al-Sabbagh A, Nelson PA, Kaul D, Charles MS, Mitchell DJ, Steinman L, Weiner HL, Kuchroo VK.''Lupus-prone'' mice are susceptible to organ-specific autoimmune disease, experimental allergic encephalomyelitis. Pathobiology. 1994;62(3):113-9.

482	Friedman A, al-Sabbagh A, Santos LM, Fishman-Lobell J, Polanski M, Das MP, Khoury SJ, Weiner HL.Oral tolerance: a biologically relevant pathway to generate peripheral tolerance against external and self antigens. Chem Immunol. 1994;58:259-90. Review.

483

Weiner HL, Friedman A, Miller A, Khoury SJ, al-Sabbagh A, Santos L, Sayegh M, Nussenblatt RB, Trentham DE, Hafler DA.Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol. 1994;12:809-37. Review.

484	al-Sabbagh A, Miller A, Santos LM, Weiner HL.Antigen-driven tissue-specific suppression following oral tolerance: orally administered myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalomyelitis in the SJL mouse. Eur J Immunol. 1994 Sep;24(9):2104-9.

485	Santos LM, al-Sabbagh A, Londono A, Weiner HL.Oral tolerance to myelin basic protein induces regulatory TGF-beta-secreting T cells in Peyer''s patches of SJL mice. Cell Immunol. 1994 Sep;157(2):439-47.

486	Khoury SJ, Guttmann CR, Orav EJ, Hohol MJ, Ahn SS, Hsu L, Kikinis R, Mackin GA, Jolesz FA, Weiner HL.Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden. Neurology. 1994 Nov;44(11):2120-4.

487	Fishman-Lobell J, Friedman A, Weiner HL.Different kinetic patterns of cytokine gene expression in vivo in orally tolerant mice. Eur J Immunol. 1994 Nov;24(11):2720-4.

488
Weiner HL.Oral tolerance. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10762-5. Review.

489	Miller A, Lider O, Abramsky O, Weiner HL.Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals. Eur J Immunol. 1994 May;24(5):1026-32.

490

Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL, et al.T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice. J Exp Med. 1994 May 1;179(5):1659-64.

491	Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA.Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med. 1994 Mar 1;179(3):973-84.

492	Friedman A, Weiner HL.Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6688-92.

493	Khoury SJ, Weiner HL.Kappa light chains in spinal fluid for diagnosing multiple sclerosis. JAMA. 1994 Jul 20;272(3):242-3.

494	Ridgway WM, Weiner HL, Fathman CG.Regulation of autoimmune response. Curr Opin Immunol. 1994 Dec;6(6):946-55. Review.

495	Weiner HL, Wisoff JH, Rosenberg ME, Kupersmith MJ, Cohen H, Zagzag D, Shiminski-Maher T, Flamm ES, Epstein FJ, Miller DC.Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome. Neurosurgery. 1994 Dec;35(6):1001-10; discussion 1010-1.

496	Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL.Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 1994 Aug 26;265(5176):1237-40.

497	Weiner HL.Treatment of autoimmune diseases by oral tolerance to autoantigens. Autoimmunity. 1993;15 Suppl:6-7. Review.

498	Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D, Lorenzo C, Sewell KL, Hafler DA, Weiner HL.Effects of oral administration of type II collagen on rheumatoid arthritis. Science. 1993 Sep 24;261(5129):1727-30.

499	Jafar JJ, Weiner HL.Surgery for angiographically occult cerebral aneurysms. J Neurosurg. 1993 Nov;79(5):674-9.

500	Hancock WW, Sayegh MH, Kwok CA, Weiner HL, Carpenter CB.Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation. Transplantation. 1993 May;55(5):1112-8.

501	Oettinger HF, al-Sabbagh A, Jingwu Z, LaSalle JM, Weiner HL, Hafler DA.Biological activity of recombinant human myelin basic protein. J Neuroimmunol. 1993 May;44(2):157-62.

502

Weiner HL, Mackin GA, Orav EJ, Hafler DA, Dawson DM, LaPierre Y, Herndon R, Lehrich JR, Hauser SL, Turel A, et al.Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group. Neurology. 1993 May;43(5):910-8.

503	Hafler DA, Zhang JW, LaSalle J, Donnelly C, Weiner HL, Wucherpfeffnig K.The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis. Clin Exp Rheumatol. 1993 Mar-Apr;11 Suppl 8:S39-40.

504

Miller A, Zhang ZJ, Sobel RA, al-Sabbagh A, Weiner HL.Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. VI. Suppression of adoptively transferred disease and differential effects of oral vs. intravenous tolerization. J Neuroimmunol. 1993 Jul;46(1-2):73-82.

505	Weiner HL, Rezai AR, Cooper PR.Sigmoid diverticular perforation in neurosurgical patients receiving high-dose corticosteroids. Neurosurgery. 1993 Jul;33(1):40-3. Review.

506	Weiner HL, Zagzag D, Babu R, Weinreb HJ, Ransohoff J.Schwannoma of the fourth ventricle presenting with hemifacial spasm. A report of two cases. J Neurooncol. 1993 Jan;15(1):37-43. Review.

507	Sayegh MH, Khoury SJ, Hancock WW, Weiner HL, Carpenter CB.Induction of immunity and oral tolerance to alloantigen by polymorphic class II major histocompatibility complex allopeptides in the rat. Transplant Proc. 1993 Feb;25(1 Pt 1):357-8.

508	Weiner HL, Mackin GA, Matsui M, Orav EJ, Khoury SJ, Dawson DM, Hafler DA.Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science. 1993 Feb 26;259(5099):1321-4.

509	Miller A, al-Sabbagh A, Santos LM, Das MP, Weiner HL.Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression. J Immunol. 1993 Dec 15;151(12):7307-15.

510	Khoury SJ, Sayegh MH, Hancock WW, Gallon L, Carpenter CB, Weiner HL.Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide. J Exp Med. 1993 Aug 1;178(2):559-66.

511	Zhang J, Weiner HL, Hafler DA.Autoreactive T cells in multiple sclerosis. Int Rev Immunol. 1992;9(3):183-201. Review.

512

Khoury SJ, Hancock WW, Weiner HL.Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J Exp Med. 1992 Nov 1;176(5):1355-64.

513	Hafler DA, Cohen I, Benjamin DS, Weiner HL.T cell vaccination in multiple sclerosis: a preliminary report. Clin Immunol Immunopathol. 1992 Mar;62(3):307-13.

514	Sayegh MH, Zhang ZJ, Hancock WW, Kwok CA, Carpenter CB, Weiner HL.Down-regulation of the immune response to histocompatibility antigens and prevention of sensitization by skin allografts by orally administered alloantigen. Transplantation. 1992 Jan;53(1):163-6.

515

Miller A, Lider O, Roberts AB, Sporn MB, Weiner HL.Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):421-5.

516	Hancock WW, Sayegh MH, Zhang ZJ, Kwok CA, Weiner HL, Carpenter CB.Oral immunization with allogeneic splenocytes inhibits development of accelerated but not acute rejection of cardiac grafts: analysis of intragraft effector mechanisms. Transplant Proc. 1992 Feb;24(1):250-1.

517	Miller A, Lider O, al-Sabbagh A, Weiner HL.Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. V. Hierarchy of suppression by myelin basic protein from different species. J Neuroimmunol. 1992 Aug;39(3):243-50.

518	Miller A, Weiner HL, Abramsky O.[The trimolecular complex as a target for specific immunotherapy in experimental autoimmune encephalomyelitis--applications for multiple sclerosis and other human autoimmune disease]. Harefuah. 1992 Aug;123(3-4):110-5. Review. Hebrew.

519	Sayegh MH, Khoury SJ, Hancock WW, Weiner HL, Carpenter CB.Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7762-6.

520	Thurau SR, Caspi RR, Chan CC, Weiner HL, Nussenblatt RB.[Immunologic suppression of experimental autoimmune uveitis]. Fortschr Ophthalmol. 1991;88(4):404-7. German.

521	Miller A, Lider O, Weiner HL.Antigen-driven bystander suppression after oral administration of antigens. J Exp Med. 1991 Oct 1;174(4):791-8.

522	Zhang ZJ, Davidson L, Eisenbarth G, Weiner HL.Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10252-6.

523	Hafler DA, Orav J, Gertz R, Stazzone L, Weiner HL.Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis. J Neuroimmunol. 1991 May;32(2):149-58.

524	Weiner HL, McCarthy EA, Pritchett EL.Regular ventricular rhythms in patients with symptomatic paroxysmal atrial fibrillation. J Am Coll Cardiol. 1991 May;17(6):1283-7.

525	Brod SA, al-Sabbagh A, Sobel RA, Hafler DA, Weiner HL.Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin antigens: IV. Suppression of chronic relapsing disease in the Lewis rat and strain 13 guinea pig. Ann Neurol. 1991 Jun;29(6):615-22.

526	Weiner HL.New diagnostic modalities for the evaluation of the patient with syncope. Del Med J. 1991 Jul;63(7):407-10. Review.

527	Hafler DA, Chofflon M, Kurt-Jones E, Weiner HL.Interleukin-1 corrects the defective autologous mixed lymphocyte response in multiple sclerosis. Clin Immunol Immunopathol. 1991 Jan;58(1):115-25.

528	Lee SJ, Wucherpfennig KW, Brod SA, Benjamin D, Weiner HL, Hafler DA.Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Ann Neurol. 1991 Jan;29(1):33-40.

529	Miller A, Hafler DA, Weiner HL.Immunotherapy in autoimmune diseases. Curr Opin Immunol. 1991 Dec;3(6):936-40. Review.

530	Hafler DA, Matsui M, Wucherpfennig KW, Ota K, Weiner HL.The potential of restricted T cell recognition of myelin basic protein epitopes in the therapy of multiple sclerosis. Ann N Y Acad Sci. 1991 Dec 30;636:251-65.

531	Weiner HL, Zhang ZJ, Khoury SJ, Miller A, al-Sabbagh A, Brod SA, Lider O, Higgins P, Sobel R, Nussenblatt RB, et al.Antigen-driven peripheral immune tolerance. Suppression of organ-specific autoimmune diseases by oral administration of autoantigens. Ann N Y Acad Sci. 1991 Dec 30;636:227-32. Review.

532	Miller A, Hafler DA, Weiner HL.Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases. FASEB J. 1991 Aug;5(11):2560-6. Review.

533	Wucherpfennig KW, Weiner HL, Hafler DA.T-cell recognition of myelin basic protein. Immunol Today. 1991 Aug;12(8):277-82. Review.

534	Lider O, Miller A, Miron S, Hershkoviz R, Weiner HL, Zhang XM, Heber-Katz E.Nonencephalitogenic CD4-CD8- V alpha 2V beta 8.2+ anti-myelin basic protein rat T lymphocytes inhibit disease induction. J Immunol. 1991 Aug 15;147(4):1208-13.

535	Zamaroczy D, Schluesener HJ, Jolesz FA, Sobel RA, Colucci VM, Weiner HL, Sandor T.Differentiation of experimental white matter lesions using multiparametric magnetic resonance measurements. Invest Radiol. 1991 Apr;26(4):317-24.

536	Wucherpfennig KW, Weiner HL.Immunologic mechanisms in chronic demyelinating diseases of the central and peripheral nervous system. Res Publ Assoc Res Nerv Ment Dis. 1990;68:105-16. Review.

537	Weiner HL, Dau PC, Khatri BO, Petajan J, Birnbaum G, McQuillen MP, Fosburg MT, Feldstein M, Orav J.Double-blind study of true vs. sham plasmapheresis in patients being treated with immunosuppression for acute attacks of multiple sclerosis. Prog Clin Biol Res. 1990;337:283.

538	Zhang ZY, Lee CS, Lider O, Weiner HL.Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen. J Immunol. 1990 Oct 15;145(8):2489-93.

539	Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA.Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science. 1990 May 25;248(4958):1016-9.

540	Nussenblatt RB, Caspi RR, Mahdi R, Chan CC, Roberge F, Lider O, Weiner HL.Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen. J Immunol. 1990 Mar 1;144(5):1689-95.

541	Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, Hafler DA.T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature. 1990 Jul 12;346(6280):183-7.

542	Toms R, Weiner HL, Johnson D.Identification of IgE-positive cells and mast cells in frozen sections of multiple sclerosis brains. J Neuroimmunol. 1990 Dec;30(2-3):169-77.

543	Khoury SJ, Lider O, al-Sabbagh A, Weiner HL.Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. III. Synergistic effect of lipopolysaccharide. Cell Immunol. 1990 Dec;131(2):302-10.

544	Santos LM, Lider O, Audette J, Khoury SJ, Weiner HL.Characterization of immunomodulatory properties and accessory cell function of small intestinal epithelial cells. Cell Immunol. 1990 Apr 15;127(1):26-34.

545	Weiner HL, Dau PC, Khatri BO, Petajan JH, Birnbaum G, McQuillen MP, Fosburg MT, Feldstein M, Orav EJ.Double-blind study of true vs. sham plasma exchange in patients treated with immunosuppression for acute attacks of multiple sclerosis. Neurology. 1989 Sep;39(9):1143-9.

546	Chofflon M, González V, Weiner HL, Hafler DA.Inflammatory cerebrospinal fluid T cells have activation requirements characteristic of CD4+CD45RA- T cells. Eur J Immunol. 1989 Oct;19(10):1791-5.

547	Chofflon M, Weiner HL, Morimoto C, Hafler DA.Decrease of suppressor inducer (CD4+2H4+) T cells in multiple sclerosis cerebrospinal fluid. Ann Neurol. 1989 May;25(5):494-9.

548	Duby AD, Weiner HL, Benjamin DS, Seidman JG, Hafler DA.Sequestration of virus-specific T cells in the cerebrospinal fluid of a patient with varicella zoster viral meningoencephalitis. J Neuroimmunol. 1989 Mar;22(1):63-8.

549
Hafler DA, Weiner HL.MS: a CNS and systemic autoimmune disease. Immunol Today. 1989 Mar;10(3):104-7. Review.

550	Weiner HL, Paty DW.Diagnostic and therapeutic trials in multiple sclerosis: a new look. Summary of Jekyll Island workshop. Neurology. 1989 Jul;39(7):972-6.

551	Hauser SL, Fleischnick E, Weiner HL, Marcus D, Awdeh Z, Yunis EJ, Alper CA.Extended major histocompatibility complex haplotypes in patients with multiple sclerosis. Neurology. 1989 Feb;39(2 Pt 1):275-7.

552	Hafler DA, Brod SA, Weiner HL.Immunoregulation in multiple sclerosis. Res Immunol. 1989 Feb;140(2):233-9; discussion 245-8. Review.

553

Lider O, Santos LM, Lee CS, Higgins PJ, Weiner HL.Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes. J Immunol. 1989 Feb 1;142(3):748-52.

554	Seeldrayers PA, Yasui D, Weiner HL, Johnson D.Treatment of experimental allergic neuritis with nedocromil sodium. J Neuroimmunol. 1989 Dec;25(2-3):221-6.

555	Weiner HL, Swain JL.Acidic fibroblast growth factor mRNA is expressed by cardiac myocytes in culture and the protein is localized to the extracellular matrix. Proc Natl Acad Sci U S A. 1989 Apr;86(8):2683-7.

556	Johnson D, Weiner HL, Seeldrayers PA.Role of mast cells in peripheral nervous system demyelination. Ann N Y Acad Sci. 1988;540:727-8.

557	Hafler DA, Weiner HL.Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human antimouse responses. Ann N Y Acad Sci. 1988;540:557-9.

558	Carter JL, Dawson DM, Hafler DA, Fallis RJ, Stazzone L, Orav J, Weiner HL.Cumulative experience with high-dose intravenous cyclophosphamide and ACTH therapy in chronic progressive multiple sclerosis. Ann N Y Acad Sci. 1988;540:535-6.

559	Chofflon M, Weiner HL, Hafler DA.Loss of functional suppression is linked to decreases in circulating suppressor-inducer (CD4+ 2H4+) T cells in multiple sclerosis. Ann N Y Acad Sci. 1988;540:330-2.

560	Sobel RA, Hafler DA, Castro EE, Morimoto C, Weiner HL.Immunohistochemical analysis of suppressor-inducer and helper-inducer T cells in multiple sclerosis brain tissue. Ann N Y Acad Sci. 1988;540:306-8.

561	Schluesener HJ, Wucherpfennig KW, Weiner HL.Gene activation during experimental allergic encephalomyelitis. Cloning of new cDNAs. Ann N Y Acad Sci. 1988;540:264-5.

562	Shepley MP, Sherry B, Weiner HL.Monoclonal antibody identification of a 100-kDa membrane protein in HeLa cells and human spinal cord involved in poliovirus attachment. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7743-7.

565	Johnson D, Seeldrayers PA, Weiner HL.The role of mast cells in demyelination. 1. Myelin proteins are degraded by mast cell proteases and myelin basic protein and P2 can stimulate mast cell degranulation. Brain Res. 1988 Mar 15;444(1):195-8.

566	Carter JL, Hafler DA, Dawson DM, Orav J, Weiner HL.Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients. Neurology. 1988 Jul;38(7 Suppl 2):9-14.

567	Hafler DA, Weiner HL.Immunosuppression with monoclonal antibodies in multiple sclerosis. Neurology. 1988 Jul;38(7 Suppl 2):42-7.

568	Schluesener HJ, Sobel RA, Weiner HL.Demyelinating experimental allergic encephalomyelitis (EAE) in the rat: treatment with a monoclonal antibody against activated T cells. J Neuroimmunol. 1988 Jul;18(4):341-51.

569	Hafler DA, Ritz J, Schlossman SF, Weiner HL.Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses. J Immunol. 1988 Jul 1;141(1):131-8.

570	Higgins PJ, Weiner HL.Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. J Immunol. 1988 Jan 15;140(2):440-5.

571	Chofflon M, Weiner HL, Morimoto C, Hafler DA.Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+ 2H4+) T cells in multiple sclerosis. Ann Neurol. 1988 Aug;24(2):185-91.

572	Sobel RA, Hafler DA, Castro EE, Morimoto C, Weiner HL.The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions. J Immunol. 1988 Apr 1;140(7):2210-4.

573	Hafler DA, Fox DA, Benjamin D, Blue ML, Weiner HL.Secondary immune amplification following live poliovirus immunization in humans. Clin Immunol Immunopathol. 1987 Sep;44(3):321-8.

574	Fallis RJ, Powers ML, Sy MS, Weiner HL.Adoptive transfer of murine chronic-relapsing autoimmune encephalomyelitis. Analysis of basic protein-reactive cells in lymphoid organs and nervous system of donor and recipient animals. J Neuroimmunol. 1987 Mar;14(2):205-19.

575	Dawson DM, Carter JL, Hafler DA, Weiner HL.Immunosuppression in progressive multiple sclerosis with high dose intravenous cyclophosphamide and monoclonal antibodies. Riv Neurol. 1987 Mar-Apr;57(2):88-91.

576	Hafler DA, Weiner HL.In vivo labeling of blood T cells: rapid traffic into cerebrospinal fluid in multiple sclerosis. Ann Neurol. 1987 Jul;22(1):89-93.

577	Hafler DA, Benjamin DS, Burks J, Weiner HL.Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis. J Immunol. 1987 Jul 1;139(1):68-72.

578	Weiner HL, Weiner LH, Swain JL.Tissue distribution and developmental expression of the messenger RNA encoding angiogenin. Science. 1987 Jul 17;237(4812):280-2.

579	Brown RH Jr, Johnson D, Ogonowski M, Weiner HL.Antineural antibodies in the serum of patients with amyotrophic lateral sclerosis. Neurology. 1987 Jan;37(1):152-5.

580	Brown RH Jr, Johnson D, Ogonowski M, Weiner HL.Type 1 human poliovirus binds to human synaptosomes. Ann Neurol. 1987 Jan;21(1):64-70.

581	Morimoto C, Hafler DA, Weiner HL, Letvin NL, Hagan M, Daley J, Schlossman SF.Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody. N Engl J Med. 1987 Jan 8;316(2):67-72.

582	Hauser SL, Che M, Fallis RJ, Weiner HL.Immunoregulatory abnormalities induced by experimental reovirus infection: functional alterations in T-cell subpopulations. Clin Immunol Immunopathol. 1987 Dec;45(3):481-90.

583	Hafler DA, Weiner HL.T cells in multiple sclerosis and inflammatory central nervous system diseases. Immunol Rev. 1987 Dec;100:307-32. Review.

584	Schluesener HJ, Sobel RA, Linington C, Weiner HL.A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J Immunol. 1987 Dec 15;139(12):4016-21.

585
Weiner HL.Cop 1 therapy for multiple sclerosis. N Engl J Med. 1987 Aug 13;317(7):442-4.

586	Fallis RJ, Powers ML, Weiner HL.Serial analysis of peripheral blood T-cell phenotypes and myelin basic protein reactivity in experimental allergic encephalomyelitis. Neurology. 1987 Apr;37(4):719-23.

587
Levin LA, Weiner HL.Antigen presentation by astrocytes--a commentary. J Mol Cell Immunol. 1986;2(5):281-2.

588	Johnson D, Hafler DA, Fallis RJ, Lees MB, Brady RO, Quarles RH, Weiner HL.Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis. J Neuroimmunol. 1986 Nov;13(1):99-108.

589	Hafler DA, Fallis RJ, Dawson DM, Schlossman SF, Reinherz EL, Weiner HL.Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12. Neurology. 1986 Jun;36(6):777-84.

590	Hauser SL, Bhan AK, Gilles F, Kemp M, Kerr C, Weiner HL.Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann Neurol. 1986 Jun;19(6):578-87.

591	Dichter MA, Weiner HL, Fields BN, Mitchell G, Noseworthy J, Gaulton G, Greene M.Antiidiotypic antibody to reovirus binds to neurons and protects from viral infection. Ann Neurol. 1986 Jun;19(6):555-8.

592	Hafler DA, Fox DA, Benjamin D, Weiner HL.Antigen reactive memory T cells are defined by Ta1. J Immunol. 1986 Jul 15;137(2):414-8.

593	Hafler DA, Johnson D, Kelly JJ, Panitch H, Kyle R, Weiner HL.Monoclonal gammopathy and neuropathy: myelin-associated glycoprotein reactivity and clinical characteristics. Neurology. 1986 Jan;36(1):75-8.

594	Brown RH Jr, Hauser SL, Harrington H, Weiner HL.Failure of immunosuppression with a ten- to 14-day course of high-dose intravenous cyclophosphamide to alter the progression of amyotrophic lateral sclerosis. Arch Neurol. 1986 Apr;43(4):383-4.

595	Hafler DA, Buchsbaum M, Weiner HL.Decreased autologous mixed lymphocyte reaction in multiple sclerosis. J Neuroimmunol. 1985 Oct;9(6):339-47.

596	Hafler DA, Buchsbaum M, Johnson D, Weiner HL.Phenotypic and functional analysis of T cells cloned directly from the blood and cerebrospinal fluid of patients with multiple sclerosis. Ann Neurol. 1985 Oct;18(4):451-8.

597	Hafler DA, Hemler ME, Christenson L, Williams JM, Shapiro HM, Strom TB, Strominger JL, Weiner HL.Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clin Immunol Immunopathol. 1985 Nov;37(2):163-71.

598	Hafler DA, Fox DA, Manning ME, Schlossman SF, Reinherz EL, Weiner HL.In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N Engl J Med. 1985 May 30;312(22):1405-11.

599	Weiner HL.An assessment of plasma exchange in progressive multiple sclerosis. Neurology. 1985 Mar;35(3):320-2.

600	Hauser SL, Ault KA, Johnson D, Hoban C, Weiner HL.Increased IgG secretion by unstimulated mononuclear cells in active multiple sclerosis and functional assessment of the T8 subset. Clin Immunol Immunopathol. 1985 Dec;37(3):312-23.

601	Weiner HL, Hauser SL, Hafler DA, Fallis RJ, Lehrich JR, Dawson DM.The use of cyclophosphamide in the treatment of multiple sclerosis. Ann N Y Acad Sci. 1984;436:373-81.

602	Weiner HL, Hafler DA, Fallis RJ, Johnson D, Ault KA, Hauser SL.T cell subsets in patients with multiple sclerosis. An overview. Ann N Y Acad Sci. 1984;436:281-93. Review.

603	Epstein RL, Finberg R, Powers ML, Weiner HL.Interaction of reovirus with cell surface receptors. IV. The reovirus type 3 receptor is expressed predominantly on murine Lyt-2,3+ and human T8+ cells. J Immunol. 1984 Sep;133(3):1614-7.

604	Dichter MA, Weiner HL.Infection of neuronal cell cultures with reovirus mimics in vitro patterns of neurotropism. Ann Neurol. 1984 Nov;16(5):603-10.

605	Hauser SL, Weiner HL, Bhan AK, Shapiro ME, Che M, Aldrich WR, Letvin NL.Lyt-1 cells mediate acute murine experimental allergic encephalomyelitis. J Immunol. 1984 Nov;133(5):2288-90.

606	Hauser SL, Weiner HL, Che M, Shapiro ME, Gilles F, Letvin NL.Prevention of experimental allergic encephalomyelitis (EAE) in the SJL/J mouse by whole body ultraviolet irradiation. J Immunol. 1984 Mar;132(3):1276-81.

607

Tardieu M, Powers ML, Hafler DA, Hauser SL, Weiner HL.Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with reovirus and demonstration of shared antigenicity between virus and lymphocytes. Eur J Immunol. 1984 Jun;14(6):561-5.

608	Hauser SL, Fosburg M, Kevy SV, Weiner HL.Lymphocytapheresis in chronic progressive multiple sclerosis: immunologic and clinical effects. Neurology. 1984 Jul;34(7):922-6.

609	Epstein RL, Powers ML, Rogart RB, Weiner HL.Binding of 125I-labeled reovirus to cell surface receptors. Virology. 1984 Feb;133(1):46-55.

610

Hauser SL, Bahn AK, Che M, Gilles F, Weiner HL.Redistribution of Lyt-bearing T cells in acute murine experimental allergic encephalomyelitis: selective migration of Lyt-1 cells to the central nervous system is associated with a transient depletion of Lyt-1 cells in peripheral blood. J Immunol. 1984 Dec;133(6):3037-42.

611	Weiner HL, Hafler DA, Fallis RJ, Johnson D, Ault KA, Hauser SL.Altered blood T-cell subsets in patients with multiple sclerosis. J Neuroimmunol. 1984 Apr;6(2):115-21.

612	Drzymala RE, Weiner HL, Dearry CA, Liebman PA.A barrier to lateral diffusion of porphyropsin in Necturus rod outer segment disks. Biophys J. 1984 Apr;45(4):683-92.

613
Weiner HL, Hauser SL.Immunoregulation in multiple sclerosis. Prog Brain Res. 1983;59:339-43.

614	Weiner HL, Tardieu M, Epstein RL, Fontana A, Powers ML.Viral interactions with receptors in the central nervous system and on lymphocytes. Prog Brain Res. 1983;59:23-7.

615	Crary B, Hauser SL, Borysenko M, Kutz I, Hoban C, Ault KA, Weiner HL, Benson H.Epinephrine-induced changes in the distribution of lymphocyte subsets in peripheral blood of humans. J Immunol. 1983 Sep;131(3):1178-81.

616	Bertino JR, Carman MD, Weiner HL, Cashmore A, Moroson BA, Srimatkandada S, Schornagel JH, Medina WD, Dube SK.Gene amplification and altered enzymes as mechanisms for the development of drug resistance. Cancer Treat Rep. 1983 Oct;67(10):901-4. Review.

617	Hauser SL, Bhan AK, Gilles FH, Hoban CJ, Reinherz EL, Schlossman SF, Weiner HL.Immunohistochemical staining of human brain with monoclonal antibodies that identify lymphocytes, monocytes, and the Ia antigen. J Neuroimmunol. 1983 Oct;5(2):197-205.

618	Tardieu M, Noseworthy JH, Perry L, Che M, Greene MI, Weiner HL.Generation of a monoclonal antibody (Epenl) which binds selectively to murine ependymal cells. Brain Res. 1983 Oct 31;277(2):339-46.

619	Weiner HL, Ellison GW.A working protocol to be used as a guideline for trials in multiple sclerosis. Arch Neurol. 1983 Oct 21;40(11):704-10.

620
Weiner HL, Ebers GC.Development of simple trial protocols. Arch Neurol. 1983 Oct 21;40(11):700.

621	Weiner HL, Dau P, Birnbaum G, Feldstein M, Khatri B, Petajan J, McQuillen MP.Plasma exchange in acute multiple sclerosis. Design of a cooperative study. Arch Neurol. 1983 Oct 21;40(11):691-2.

622	Hauser SL, Dawson DM, Lehrich JR, Beal MF, Kevy SV, Weiner HL.Immunosuppression and plasmapheresis in chronic progressive multiple sclerosis. Design of a clinical trial. Arch Neurol. 1983 Oct 21;40(11):687-90.

623	Hauser SL, Reinherz EL, Hoban CJ, Schlossman SF, Weiner HL.CSF cells in multiple sclerosis: monoclonal antibody analysis and relationship to peripheral blood T-cell subsets. Neurology. 1983 May;33(5):575-9.

624	Tardieu M, Powers ML, Weiner HL.Age dependent susceptibility to Reovirus type 3 encephalitis: role of viral and host factors. Ann Neurol. 1983 Jun;13(6):602-7.

625	Hauser SL, Dawson DM, Lehrich JR, Beal MF, Kevy SV, Propper RD, Mills JA, Weiner HL.Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. N Engl J Med. 1983 Jan 27;308(4):173-80.

626	Hauser SL, Reinherz EL, Hoban CJ, Schlossman SF, Weiner HL.Immunoregulatory T-cells and lymphocytotoxic antibodies in active multiple sclerosis: weekly analysis over a six-month period. Ann Neurol. 1983 Apr;13(4):418-25.

627	Liebman PA, Weiner HL, Drzymala RE.Lateral diffusion of visual pigment in rod disk membranes. Methods Enzymol. 1982;81:660-8.

628	Tardieu M, Epstein RL, Weiner HL.Interaction of viruses with cell surface receptors. Int Rev Cytol. 1982;80:27-61. Review.

629	Hauser SL, Fosburg M, Kevy S, Weiner HL.Plasmapheresis, lymphocytapheresis, and immunosuppressive drug therapy in multiple sclerosis. Prog Clin Biol Res. 1982;106:239-54. Review.

630	Nepom JT, Tardieu M, Epstein RL, Noseworthy JH, Weiner HL, Gentsch J, Fields BN, Greene MI.Virus-binding receptors: similarities to immune receptors as determined by anti-idiotypic antibodies. Surv Immunol Res. 1982;1(3):255-61. Review.

631	Hauser SL, Ropper AH, Perlo VP, Reinherz EL, Schlossman SF, Weiner HL.T-cell subsets in human autoimmune diseases. Neurology. 1982 Nov;32(11):1320-1.

632	Hauser SL, Bresnan MJ, Reinherz EL, Weiner HL.Childhood multiple sclerosis: clinical features and demonstration of changes in T cell subsets with disease activity. Ann Neurol. 1982 May;11(5):463-8.

633	Weiner HL, Hauser SL.Neuroimmunology I: Immunoregulation in neurological disease. Ann Neurol. 1982 May;11(5):437-49.

634	Tardieu M, Weiner HL.Viral receptors on isolated murine and human ependymal cells. Science. 1982 Jan 22;215(4531):419-21.

635	Nepom JT, Weiner HL, Dichter MA, Tardieu M, Spriggs DR, Gramm CF, Powers ML, Fields BN, Greene MI.Identification of a hemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells. J Exp Med. 1982 Jan 1;155(1):155-67.

636	Weiner HL, Hauser SL.Neuroimmunology. II: Antigenic specificity of the nervous system. Ann Neurol. 1982 Dec;12(6):499-509. Review.

637	Hauser SL, Weiner HL, Ault KA.Clonally restricted B cells in peripheral blood of multiple sclerosis patients: kappa/lambda staining patterns. Ann Neurol. 1982 Apr;11(4):408-12.

638	Hauser SL, Ault KA, Levin MJ, Garovoy MR, Weiner HL.Natural killer cell activity in multiple sclerosis. J Immunol. 1981 Sep;127(3):1114-7.

639	Rubin D, Weiner HL, Fields BN, Greene MI.Immunologic tolerance after oral administration of reovirus: requirement for two viral gene products for tolerance induction. J Immunol. 1981 Oct;127(4):1697-701.

640	Epstein RL, Powers ML, Weiner HL.Interaction of reovirus with cell surface receptors. III. Reovirus type 3 induces capping of viral receptors on murine lymphocytes. J Immunol. 1981 Nov;127(5):1800-3.

641	Finberg R, Weiner HL, Burakoff SJ, Fields BN.Type-specific reovirus antiserum blocks the cytotoxic T-cell-target cell interaction: evidence for the association of the viral hemagglutinin of a nonenveloped virus with the cell surface. Infect Immun. 1981 Feb;31(2):646-9.

642	Fields BN, Weiner HL, Drayna DT, Sharpe AH.The role of the reovirus hemagglutinin in viral virulence. Ann N Y Acad Sci. 1980;354:125-34. Review.

643	Weiner HL, Dawson DM.Plasmapheresis in multiple sclerosis: preliminary study. Neurology. 1980 Oct;30(10):1029-33.

644
Weiner IH, Weiner HL.Nocturnal leg muscle cramps. JAMA. 1980 Nov 21;244(20):2332-3.

645	Weiner HL, Powers ML, Fields BN.Absolute linkage of virulence and central nervous system cell tropism of reoviruses to viral hemagglutinin. J Infect Dis. 1980 May;141(5):609-16.

646	Weiner HL, Ault KA, Fields BN.Interaction of reovirus with cell surface receptors. I. Murine and human lymphocytes have a receptor for the hemagglutinin of reovirus type 3. J Immunol. 1980 May;124(5):2143-8.

647	Greene MI, Weiner HL.Delayed hypersensitivity in mice infected with reovirus. II. Induction of tolerance and suppressor T cells to viral specific gene products. J Immunol. 1980 Jul;125(1):283-7.

648	Weiner HL, Greene MI, Fields BN.Delayed hypersensitivity in mice infected with reovirus. I. Identification of host and viral gene products responsible for the immune response. J Immunol. 1980 Jul;125(1):278-82.

649	Reinherz EL, Weiner HL, Hauser SL, Cohen JA, Distaso JA, Schlossman SF.Loss of suppressor T cells in active multiple sclerosis. Analysis with monoclonal antibodies. N Engl J Med. 1980 Jul 17;303(3):125-9.

650	Fontana A, Weiner HL.Interaction of reovirus with cell surface receptors. II. Generation of suppressor T cells by the hemagglutinin of reovirus type 3. J Immunol. 1980 Dec;125(6):2660-4.

651	Hauser SL, Weiner HL, Bresnan MJ, Ault KA.Lymphocyte capping in muscular dystrophy. Neurology. 1979 Oct;29(10):1419-21.

652	Weiner HL, Schocket AL.Lymphocytes in multiple sclerosis: correlation with CSF immunoglobulins and cold-reactive lymphocytotoxic antibodies. Neurology. 1979 Nov;29(11):1504-8.

653	Ault KA, Weiner HL.Natural killing of measles-infected cells by human lymphocytes. J Immunol. 1979 Jun;122(6):2611-6.

654	Finberg R, Weiner HL, Fields BN, Benacerraf B, Burakoff SJ.Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene. Proc Natl Acad Sci U S A. 1979 Jan;76(1):442-6.

655	Wechsler SL, Weiner HL, Fields BN.Immune response in subacute sclerosing panencephalitis: reduced antibody response to the matrix protein of measles virus. J Immunol. 1979 Aug;123(2):884-9.

656	Ault KA, Weiner HL.Isolation and characterization of the class of human blood lymphocytes responsible for antibody-dependent cellular cytotoxicity. Clin Immunol Immunopathol. 1978 Sep;11(1):60-76.

657	Weiner HL, Cherry J, McIntosh K.Decreased lymphocyte transformation to vaccinia virus in multiple sclerosis. Neurology. 1978 May;28(5):415-20.

658	Weiner HL, Ramig RF, Mustoe TA, Fields BN.Identification of the gene coding for the hemagglutinin of reovirus. Virology. 1978 May 15;86(2):581-4.

659	Weiner HL, Scribner DJ, Schocket AL, Moorhead JW.Increased proliferative response of human peripheral blood lymphocytes to anti-immunoglobulin antibodies in elderly people. Clin Immunol Immunopathol. 1978 Mar;9(3):356-62.

660
Weiner HL.Changing private practice: can we get more for less? J Calif Dent Assoc. 1978 Mar;6(3):62-3.

661	Schocket AL, Weiner HL.Lymphocytotoxic antibodies in family members of patients with multiple sclerosis. Lancet. 1978 Mar 18;1(8064):571-3.

662	Weiner HL, Scribner DJ, Moorhead JW.Anti-immunoglobulin stimulation of murine lymphocytes. IV. Re-expression and fate of cell surface receptors during stimulation. J Immunol. 1978 Jun;120(6):1907-12.

663	Scribner DJ, Weiner HL, Moorhead JW.Anti-immunoglobulin stimulation of murine lymphocytes. V. Age-related decline in Fc receptor-mediated immunoregulation. J Immunol. 1978 Jul;121(1):377-82.

664	Weiner HL, Fields BN.Neutralization of reovirus: the gene responsible for the neutralization antigen. J Exp Med. 1977 Nov 1;146(5):1305-10.

665	Weiner HL, Schocket AL, Lehrich JR.Lymphocytotix antibodies in subacute sclerosing panencephalitis and amyotrophic lateral sclerosis. Lancet. 1977 May 7;1(8019):1013-4.

666	Weiner HL, Scribner DJ, Moorhead JW.Anti-immunoglobulin stimulation of murine lymphocytes. III. Enhancement of the development of responsive B cells by thymic deprivation. Cell Immunol. 1977 Jun 1;31(1):77-84.

667	Schocket AL, Weiner HL, Walker J, McIntosh K, Kohler PF.Lymphocytotoxic antibodies in multiple sclerosis. Clin Immunol Immunopathol. 1977 Jan;7(1):15-23.

668	Weiner HL, Drayna D, Averill DR Jr, Fields BN.Molecular basis of reovirus virulence: role of the S1 gene. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5744-8.

669	Scribner DJ, Weiner HL, Moorhead JW.Surface immunoglobulin and Fc receptors on murine B lymphocytes: loss of receptor interaction after cell activation. J Immunol. 1977 Dec;119(6):2084-8.

670	Weiner HL, Moorhead JW, Yamaga K, Kubo RT.Anti-immunoglobulin stimulation of murine lymphocytes. II. Identification of cell surface target molecules and requirements for cross-linkage. J Immunol. 1976 Nov;117(5 Pt 1):1527-31.

671	Weiner HL, Moorhead JW, Claman HN.Anti-immunoglobulin stimulation of murine lymphocytes. I. Age dependency of the proliferative response. J Immunol. 1976 Jun;116(6):1656-61.

672	Weiner HL, Robinson WA.Leukopoietic activity in human urine following operative procedures. Proc Soc Exp Biol Med. 1971 Jan;136(1):29-33.

673	WEINER HL.The non-surgical treatment of dacryostenosis; a preliminary report. J Albert Einstein Med Cent (Phila). 1957 Dec;6(1):17-9.

676

Takenaka MC, Gabriely G, Rothhammer V, Mascanfroni ID, Wheeler MA, Chao CC, Gutiérrez-Vázquez C, Kenison J, Tjon EC, Barroso A, Vandeventer T, de Lima KA, Rothweiler S, Mayo L, Ghannam S, Zandee S, Healy L, Sherr D, Farez MF, Prat A, Antel J, Reardon DA, Zhang H, Robson SC, Getz G, Weiner HL, Quintana FJ.Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. Nat Neurosci. 2019 May;22(5):729-740.

677	Aschenbrenner D, Foglierini M, Jarrossay D, Hu D, Weiner HL, Kuchroo VK, Lanzavecchia A, Notarbartolo S, Sallusto F.An immunoregulatory and tissue-residency program modulated by c-MAF in human T_H17 cells. Nat Immunol. 2018 Oct;19(10):1126-1136.

678	Tankou SK, Regev K, Healy BC, Cox LM, Tjon E, Kivisakk P, Vanande IP, Cook S, Gandhi R, Glanz B, Stankiewicz J, Weiner HL.Investigation of probiotics in multiple sclerosis. Mult Scler. 2018 Jan;24(1):58-63.

679	Regev K, Paul A, Healy B, von Glenn F, Diaz-Cruz C, Gholipour T, Mazzola MA, Raheja R, Nejad P, Glanz BI, Kivisakk P, Chitnis T, Weiner HL, Gandhi R.Comprehensive evaluation of serum microRNAs as biomarkers in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016 Aug 23;3(5):e267.

680

Butovsky O, Jedrychowski MP, Cialic R, Krasemann S, Murugaiyan G, Fanek Z, Greco DJ, Wu PM, Doykan CE, Kiner O, Lawson RJ, Frosch MP, Pochet N, Fatimy RE, Krichevsky AM, Gygi SP, Lassmann H, Berry J, Cudkowicz ME, Weiner HL.Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice. Ann Neurol. 2015 Jan;77(1):75-99.

681

Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, Gygi SP, Antel JP, Weiner HL.Identification of a unique TGF-?-dependent molecular and functional signature in microglia. Nat Neurosci Nat Neurosci. 2014 Sep;17(9):1286. . 2014 Jan;17(1):131-43.

682	Sotnikov I, Veremeyko T, Starossom SC, Barteneva N, Weiner HL, Ponomarev ED.Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation. PLoS One. 2013;8(3):e58979.

683	Farez MF, Quintana FJ, Gandhi R, Izquierdo G, Lucas M, Weiner HL.Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE. Nat Immunol Nat Immunol. 2010 Jan;11(1):97. . 2009 Sep;10(9):958-64.

684	Vaknin-Dembinsky A, Brass SD, Gandhi R, Weiner HL.Membrane bound IL-15 is increased on CD14 monocytes in early stages of MS. J Neuroimmunol J Neuroimmunol. 2009 Feb 15;207(1-2):122. Brass, Steven [corrected to Brass, Steven D]. . 2008 Mar;195(1-2):135-9.

685	Weiner HL, Frenkel D.Immunology and immunotherapy of Alzheimer''s disease. Nat Rev Immunol Nat Rev Immunol. 2006 Jun;6(6):490. . 2006 May;6(5):404-16.

686	Vaknin-Dembinsky A, Balashov K, Weiner HL.IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol J Immunol. 2006 Aug 1;177(3):2025. . 2006 Jun 15;176(12):7768-74.

687	Frenkel D, Huang Z, Maron R, Koldzic DN, Moskowitz MA, Weiner HL.Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke. J Neurol Sci J Neurol Sci. 2013 Mar 15;326(1-2):123. . 2005 Jun 15;233(1-2):125-32.

688

Chi SN, Gardner SL, Levy AS, Knopp EA, Miller DC, Wisoff JH, Weiner HL, Finlay JL.Feasibility and response to induction chemotherapy intensified with high-dose methotrexate for young children with newly diagnosed high-risk disseminated medulloblastoma. J Clin Oncol J Clin Oncol. 2005 Apr 20;23(12):2877. . 2004 Dec 15;22(24):4881-7.

689	Monsonego A, Imitola J, Zota V, Oida T, Weiner HL.Microglia-mediated nitric oxide cytotoxicity of T cells following amyloid beta-peptide presentation to Th1 cells. J Immunol J Immunol. 2004 Jan 1;172(1):717. . 2003 Sep 1;171(5):2216-24.

690	Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo VK, Weiner HL.Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature Nature 1995 Sep 21;377(6546):257. . 1995 Jul 13;376(6536):177-80.

691	Weiner HL, Hohol MJ, Khoury SJ, Dawson DM, Hafler DA.Therapy for multiple sclerosis. Neurol Clin Neurol Clin 1995 May;13(2):followi. . 1995 Feb;13(1):173-96.

692	Hafler DA, Duby AD, Lee SJ, Benjamin D, Seidman JG, Weiner HL.Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis. J Exp Med J Exp Med 1988 Jul 1;168(1):459. . 1988 Apr 1;167(4):1313-22.

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